دورية أكاديمية
Molecular docking studies on α-amylase inhibitory peptides from milk of different farm animals.
| العنوان: | Molecular docking studies on α-amylase inhibitory peptides from milk of different farm animals. |
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| المؤلفون: | Mudgil P; Department of Food Science, College of Agriculture and Veterinary Medicine, United Arab Emirates University, Al Ain, 15551, United Arab Emirates. Electronic address: priti.d@uaeu.ac.ae., Al Dhaheri MKO; Department of Food Science, College of Agriculture and Veterinary Medicine, United Arab Emirates University, Al Ain, 15551, United Arab Emirates., Alsubousi MSM; Department of Food Science, College of Agriculture and Veterinary Medicine, United Arab Emirates University, Al Ain, 15551, United Arab Emirates., Khan H; Department of Food Science, College of Agriculture and Veterinary Medicine, United Arab Emirates University, Al Ain, 15551, United Arab Emirates., Redha AA; The Department of Public Health and Sport Sciences, University of Exeter Medical School, Faculty of Health and Life Sciences, University of Exeter, Exeter, EX1 2LU, United Kingdom; Centre for Nutrition and Food Sciences, Queensland Alliance for Agriculture and Food Innovation (QAAFI), The University of Queensland, Brisbane, QLD 4072, Australia., Yap PG; Analytical Biochemistry Research Centre (ABrC), Universiti Sains Malaysia, 11800, USM, Penang, Malaysia., Gan CY; Analytical Biochemistry Research Centre (ABrC), Universiti Sains Malaysia, 11800, USM, Penang, Malaysia., Maqsood S; Department of Food Science, College of Agriculture and Veterinary Medicine, United Arab Emirates University, Al Ain, 15551, United Arab Emirates; Zayed Centre of Health Science, United Arab Emirates University, Al Ain 15551, United Arab Emirates. Electronic address: sajid.m@uaeu.ac.ae. |
| المصدر: | Journal of dairy science [J Dairy Sci] 2024 May; Vol. 107 (5), pp. 2633-2652. Date of Electronic Publication: 2023 Dec 14. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: American Dairy Science Association Country of Publication: United States NLM ID: 2985126R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1525-3198 (Electronic) Linking ISSN: 00220302 NLM ISO Abbreviation: J Dairy Sci Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Champaign, IL : American Dairy Science Association Original Publication: Lancaster, Pa. [etc.] |
| مواضيع طبية MeSH: | Probiotics* , Diabetes Mellitus*/veterinary , Cattle Diseases* , Goat Diseases* , Sheep Diseases*, Animals ; Cattle ; Sheep ; Milk/chemistry ; Molecular Docking Simulation ; Animals, Domestic ; alpha-Amylases/analysis ; Camelus ; Peptides/analysis ; Goats ; Fermentation |
| مستخلص: | Milk-derived peptides have emerged as a popular mean to manage various lifestyle disorders such as diabetes. Fermentation is being explored as one of the faster and efficient way of producing peptides with antidiabetic potential. Therefore, in this study, an attempt was made to comparatively investigate the pancreatic α-amylase (PAA) inhibitory properties of peptides derived from milk of different farm animals through probiotic fermentation. Peptide's identification was carried out using liquid chromatography-quadrupole time-of-flight mass spectrometry and inhibition mechanisms were characterized by molecular docking. Results obtained showed a PAA-IC (The Authors. Published by Elsevier Inc. on behalf of the American Dairy Science Association®. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).) |
| فهرسة مساهمة: | Keywords: antidiabetic bioactive peptides; milk fermentation; molecular docking; probiotics; α-amylase inhibition |
| المشرفين على المادة: | EC 3.2.1.1 (alpha-Amylases) 0 (Peptides) |
| تواريخ الأحداث: | Date Created: 20231215 Date Completed: 20240422 Latest Revision: 20240422 |
| رمز التحديث: | 20240422 |
| DOI: | 10.3168/jds.2023-24118 |
| PMID: | 38101739 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1525-3198 |
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| DOI: | 10.3168/jds.2023-24118 |