دورية أكاديمية
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The Role of Osteogenic Effect and Vascular Function in Bone Health in Hypertensive Rats: A Study of Anti-hypertensive and Hemorheologic Drugs.

التفاصيل البيبلوغرافية
العنوان: The Role of Osteogenic Effect and Vascular Function in Bone Health in Hypertensive Rats: A Study of Anti-hypertensive and Hemorheologic Drugs.
المؤلفون: Pal S; Division of Endocrinology, CSIR-Central Drug Research Institute, Council of Scientific and Industrial Research, Lucknow, 226031, India., Sharma S; Division of Endocrinology, CSIR-Central Drug Research Institute, Council of Scientific and Industrial Research, Lucknow, 226031, India.; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, 201002, India., Porwal K; Division of Endocrinology, CSIR-Central Drug Research Institute, Council of Scientific and Industrial Research, Lucknow, 226031, India., Tiwari MC; Division of Endocrinology, CSIR-Central Drug Research Institute, Council of Scientific and Industrial Research, Lucknow, 226031, India., Khan YA; Division of Endocrinology, CSIR-Central Drug Research Institute, Council of Scientific and Industrial Research, Lucknow, 226031, India., Kumar S; Department of Mechanical Engineering, Indian Institute of Technology Ropar, Rupnagar, 140001, Punjab, India., Kumar N; Department of Mechanical Engineering, Indian Institute of Technology Ropar, Rupnagar, 140001, Punjab, India., Chattopadhyay N; Division of Endocrinology, CSIR-Central Drug Research Institute, Council of Scientific and Industrial Research, Lucknow, 226031, India. n_chattopadhyay@cdri.res.in.; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, 201002, India. n_chattopadhyay@cdri.res.in.; Division of Endocrinology, CSIR-Central Drug Research Institute, Sector 10, Jankipuram Extension, Sitapur Road, Lucknow, 226 031, India. n_chattopadhyay@cdri.res.in.
المصدر: Calcified tissue international [Calcif Tissue Int] 2024 Mar; Vol. 114 (3), pp. 295-309. Date of Electronic Publication: 2023 Dec 15.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Springer Verlag Country of Publication: United States NLM ID: 7905481 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-0827 (Electronic) Linking ISSN: 0171967X NLM ISO Abbreviation: Calcif Tissue Int Subsets: MEDLINE
أسماء مطبوعة: Publication: New York Ny : Springer Verlag
Original Publication: Berlin, New York, Springer International.
مواضيع طبية MeSH: Hypertension*/drug therapy , Pentoxifylline*/pharmacology, Humans ; Rats ; Female ; Animals ; Antihypertensive Agents/pharmacology ; Antihypertensive Agents/therapeutic use ; Bone Density ; Timolol/pharmacology ; Timolol/therapeutic use ; Rats, Inbred SHR ; Hydralazine/pharmacology ; Hydralazine/therapeutic use ; Blood Pressure
مستخلص: Vascular dysfunction contributes to the development of osteopenia in hypertensive patients, as decreased blood supply to bones results in tissue damage and dysfunction. The effect of anti-hypertensive medicines on bone mass in hypertensive individuals is inconclusive because of the varied mechanism of their action, and suggests that reducing blood pressure (BP) alone is insufficient to enhance bone mass in hypertension. Pentoxifylline (PTX), a hemorheological drug, improves blood flow by reducing blood viscosity and angiogenesis, also has an osteogenic effect. We hypothesized that improving vascular function is critical to increasing bone mass in hypertension. To test this, we screened various anti-hypertensive drugs for their in vitro osteogenic effect, from which timolol and hydralazine were selected. In adult female spontaneously hypertensive rats (SHRs), timolol and hydralazine did not improve vascular function and bone mass, but PTX improved both. In female SHR animals, PTX restored bone mass, strength and mineralization, up to the level of normotensive control rats. In addition, we observed lower blood vasculature in the femur of adult SHR animals, and PTX restored them. PTX also restored the bone vascular and angiogenesis parameters that had been impaired in OVX SHR compared to sham SHR. This study demonstrates the importance of vascular function in addition to increased bone mass for improving bone health as achieved by PTX without affecting BP, and suggests a promising treatment option for osteoporosis in hypertensive patients, particularly at-risk postmenopausal women.
(© 2023. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.)
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فهرسة مساهمة: Keywords: Bone formation; Bone vasculature; Osteogenic; Pentoxifylline; Spontaneously hypertensive rats (SHR)
المشرفين على المادة: 0 (Antihypertensive Agents)
817W3C6175 (Timolol)
SD6QCT3TSU (Pentoxifylline)
26NAK24LS8 (Hydralazine)
تواريخ الأحداث: Date Created: 20231215 Date Completed: 20240229 Latest Revision: 20240709
رمز التحديث: 20240709
DOI: 10.1007/s00223-023-01170-4
PMID: 38102510
قاعدة البيانات: MEDLINE
الوصف
تدمد:1432-0827
DOI:10.1007/s00223-023-01170-4