دورية أكاديمية
SEROPREVALENCE TO SCHISTOSOMA SOLUBLE EGG ANTIGEN AMONG NOMADIC PASTORALISTS RESIDING IN NORTHERN SENEGAL.
| العنوان: | SEROPREVALENCE TO SCHISTOSOMA SOLUBLE EGG ANTIGEN AMONG NOMADIC PASTORALISTS RESIDING IN NORTHERN SENEGAL. |
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| المؤلفون: | Seck MC; Department of Parasitology, Faculty of Medicine and Pharmacy, Cheikh Anta Diop University, Dakar 16477, Senegal.; International Research & Training Center in Applied Genomics and Health Surveillance (CIGASS), Cheikh Anta Diop University, Dakar 16477, Senegal., Badiane AS; Department of Parasitology, Faculty of Medicine and Pharmacy, Cheikh Anta Diop University, Dakar 16477, Senegal.; International Research & Training Center in Applied Genomics and Health Surveillance (CIGASS), Cheikh Anta Diop University, Dakar 16477, Senegal., Thwing J; Division of Parasitic Diseases and Malaria, U.S. Centers for Disease Control and Prevention, Atlanta, Georgia 30329., Ndiaye M; Department of Parasitology, Faculty of Medicine and Pharmacy, Cheikh Anta Diop University, Dakar 16477, Senegal.; International Research & Training Center in Applied Genomics and Health Surveillance (CIGASS), Cheikh Anta Diop University, Dakar 16477, Senegal., Diongue K; Department of Parasitology, Faculty of Medicine and Pharmacy, Cheikh Anta Diop University, Dakar 16477, Senegal.; International Research & Training Center in Applied Genomics and Health Surveillance (CIGASS), Cheikh Anta Diop University, Dakar 16477, Senegal., Ndiaye IM; International Research & Training Center in Applied Genomics and Health Surveillance (CIGASS), Cheikh Anta Diop University, Dakar 16477, Senegal., Diallo MA; Department of Parasitology, Faculty of Medicine and Pharmacy, Cheikh Anta Diop University, Dakar 16477, Senegal.; International Research & Training Center in Applied Genomics and Health Surveillance (CIGASS), Cheikh Anta Diop University, Dakar 16477, Senegal., Sy M; International Research & Training Center in Applied Genomics and Health Surveillance (CIGASS), Cheikh Anta Diop University, Dakar 16477, Senegal., Gomis JF; International Research & Training Center in Applied Genomics and Health Surveillance (CIGASS), Cheikh Anta Diop University, Dakar 16477, Senegal., Ndiaye T; International Research & Training Center in Applied Genomics and Health Surveillance (CIGASS), Cheikh Anta Diop University, Dakar 16477, Senegal., Gaye A; International Research & Training Center in Applied Genomics and Health Surveillance (CIGASS), Cheikh Anta Diop University, Dakar 16477, Senegal., Lee YM; Division of Parasitic Diseases and Malaria, U.S. Centers for Disease Control and Prevention, Atlanta, Georgia 30329., Secor WE; Division of Parasitic Diseases and Malaria, U.S. Centers for Disease Control and Prevention, Atlanta, Georgia 30329., Ndiaye D; Department of Parasitology, Faculty of Medicine and Pharmacy, Cheikh Anta Diop University, Dakar 16477, Senegal.; International Research & Training Center in Applied Genomics and Health Surveillance (CIGASS), Cheikh Anta Diop University, Dakar 16477, Senegal., Rogier E; Current address: Division of Digestive Disease and Nutrition, University of Kentucky, Lexington, Kentucky 40506.; At the time of this work was employed by the U.S. Centers for Disease Control and Prevention, Atlanta, Georgia 30329. |
| المصدر: | The Journal of parasitology [J Parasitol] 2023 Nov 01; Vol. 109 (6), pp. 580-587. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: American Society of Parasitologists [etc.] Country of Publication: United States NLM ID: 7803124 Publication Model: Print Cited Medium: Internet ISSN: 1937-2345 (Electronic) Linking ISSN: 00223395 NLM ISO Abbreviation: J Parasitol Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Lawrence, Kans. [etc.] American Society of Parasitologists [etc.] |
| مواضيع طبية MeSH: | Schistosoma mansoni* , Schistosomiasis mansoni*/epidemiology, Animals ; Humans ; Male ; Aged ; Young Adult ; Adult ; Female ; Senegal/epidemiology ; Seroepidemiologic Studies ; Immunoglobulin G |
| مستخلص: | Urinary and intestinal schistosomiasis are endemic in Senegal, with prevalence heterogeneous throughout the country. Because of their way of life, nomadic pastoralists are not typically included in epidemiological surveys, and data on the prevalence of schistosomiasis in Senegalese nomadic populations are largely non-existent. The purpose of this study was to determine the seroprevalence of schistosomiasis in Senegalese nomadic pastoralists. A modified snowball sampling survey was conducted among 1,467 nomadic pastoralists aged 6 mo and older in 5 districts in northern Senegal. Dried blood spots from participants of all ages and data regarding demographics were collected to assess IgG antibody responses against Schistosoma mansoni soluble egg antigen (SEA) using a bead-based multiplex assay. Out of 1,467 study subjects, 1,464 (99.8%) provided IgG serological data that cleared quality assurance. Of the participants with appropriate data, 56.6% were male, the median age was 22 yr, and 31.6% were under 15 yr of age. The overall anti-SEA IgG seroprevalence was 19.1% (95% confidence interval [CI]: 17.1-21.1%) with the highest estimates observed in Dagana (35.9%) and the lowest observed in Podor nomadic groups (3.4%). Antibody responses increased significantly with age except for the oldest age groups (>40 yr of age), which saw lower levels of antibody response compared to younger adults. When controlling for age and location by multivariate regression, the male sex was associated with a 2-fold greater odds of anti-SEA IgG seropositivity (aPOR: 2.0; 95% CI: 1.5-2.7). Serosurveys for anti-SEA IgG among nomadic peoples in northern Senegal found a substantial percentage of individuals with evidence for current or previous Schistosoma spp. infection with the highest levels of exposure in the district adjacent to the Diama dam along the Senegal River. With IgG prevalence increased by age except in the older adults, and the male sex significantly associated with seropositivity, these data point toward sex-associated behavioral practices and human environmental modification as risk factors for Schistosoma exposure. (© American Society of Parasitologists 2023.) |
| فهرسة مساهمة: | Keywords: Nomadic pastoralist; Schistosoma egg extract; Schistosomiasis; Senegal; Serology |
| المشرفين على المادة: | 0 (Immunoglobulin G) |
| تواريخ الأحداث: | Date Created: 20231217 Date Completed: 20231219 Latest Revision: 20240419 |
| رمز التحديث: | 20240419 |
| DOI: | 10.1645/22-69 |
| PMID: | 38104629 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1937-2345 |
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| DOI: | 10.1645/22-69 |