دورية أكاديمية
Concentration-dependent effects of reductive pulmonary inhalants on ultrafine particle-induced oxidative stress: Insights for health risk assessment.
| العنوان: | Concentration-dependent effects of reductive pulmonary inhalants on ultrafine particle-induced oxidative stress: Insights for health risk assessment. |
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| المؤلفون: | Yu YQ; BIC-ESAT and SKL-ESPC, College of Environmental Sciences and Engineering, Peking University, Beijing, 100871, PR China.; School of Environmental Science and Engineering, Qingdao University, Qingdao, 266071, PR China., Zhu T; BIC-ESAT and SKL-ESPC, College of Environmental Sciences and Engineering, Peking University, Beijing, 100871, PR China. |
| المصدر: | Environmental science and ecotechnology [Environ Sci Ecotechnol] 2023 Nov 14; Vol. 19, pp. 100339. Date of Electronic Publication: 2023 Nov 14 (Print Publication: 2024). |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier B.V Country of Publication: Netherlands NLM ID: 9918453988906676 Publication Model: eCollection Cited Medium: Internet ISSN: 2666-4984 (Electronic) Linking ISSN: 26664984 NLM ISO Abbreviation: Environ Sci Ecotechnol Subsets: PubMed not MEDLINE |
| أسماء مطبوعة: | Original Publication: [Amsterdam] : Elsevier B.V., [2020]- |
| مستخلص: | The impact of reductive pulmonary inhalants on ultrafine particles (UFPs)-induced pulmonary oxidative stress remains a crucial consideration, yet the concentration-dependent effects of these inhalants have remained unexplored. Here we synthesized composite UFPs simulating atmospheric UFPs, primarily composed of metals and quinones. We subjected these UFPs to varying concentrations (0-7000 μM) of two reductive pulmonary inhalants, N-acetylcysteine and salbutamol, to assess their influence on oxidative potential, measured through the dithiothreitol assay (OP DTT ). Simultaneously, we analysed the soluble metal content of UFPs to uncover potential relationships between oxidative potential and metal solubility. Our results unveil a dual role played by these inhalants in shaping the OP DTT of composite UFPs. Specifically, OP DTT generally increased as inhalant concentrations rose from 0 to 300 μM. However, an intriguing reversal occurred when concentrations exceeded 500 μM, resulting in a decline in OP DTT . Relative to untreated UFPs, these inhalants induced promotion and inhibition effects within concentration ranges of 100-500 and >1000 μM, respectively. While no significant correlation emerged between OP DTT and soluble metal content as inhalant concentrations ranged from 0 to 7000 μM, noteworthy positive correlations emerged at lower inhalant concentrations (e.g., N-acetylcysteine at 0-300 μM). These findings provide insights into the potential influence of reductive pulmonary inhalants on health risks associated with UFP exposure, further underscoring the need for continued research in this critical area. Competing Interests: The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. (© 2023 The Authors.) |
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| فهرسة مساهمة: | Keywords: Concentration-dependent effects; Oxidative potential; Reductive pulmonary inhalants; Simulated atmospheric ultrafine particles; Soluble metals |
| تواريخ الأحداث: | Date Created: 20231218 Latest Revision: 20231219 |
| رمز التحديث: | 20231219 |
| مُعرف محوري في PubMed: | PMC10724529 |
| DOI: | 10.1016/j.ese.2023.100339 |
| PMID: | 38107555 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 2666-4984 |
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| DOI: | 10.1016/j.ese.2023.100339 |