دورية أكاديمية
Glucose microenvironment sensitive degradation of arginine modified calcium sulfate reinforced poly(lactide- co -glycolide) composite scaffolds.
| العنوان: | Glucose microenvironment sensitive degradation of arginine modified calcium sulfate reinforced poly(lactide- co -glycolide) composite scaffolds. |
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| المؤلفون: | Zhu Y; 8th Department of Orthopaedics, Foshan Hospital of Traditional Chinese Medicine, Foshan 528000, P. R. China. Zhuyz@fshtcm.com.cn., Li Y; 8th Department of Orthopaedics, Foshan Hospital of Traditional Chinese Medicine, Foshan 528000, P. R. China. Zhuyz@fshtcm.com.cn., Zhou X; Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, 5625 Renmin Street, Changchun 130022, P. R. China. guomin@ciac.ac.cn.; School of Applied Chemistry and Engineering, University of Science and Technology of China, 96 Jinzhai Road, Hefei, Anhui 230026, P. R. China., Li H; Department of Spine Surgery, China-Japan Union Hospital of Jilin University, N. 126 Xiantai Street, Changchun 130033, Jilin, P. R. China., Guo M; Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, 5625 Renmin Street, Changchun 130022, P. R. China. guomin@ciac.ac.cn., Zhang P; Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, 5625 Renmin Street, Changchun 130022, P. R. China. guomin@ciac.ac.cn.; School of Applied Chemistry and Engineering, University of Science and Technology of China, 96 Jinzhai Road, Hefei, Anhui 230026, P. R. China. |
| المصدر: | Journal of materials chemistry. B [J Mater Chem B] 2024 Jan 03; Vol. 12 (2), pp. 508-524. Date of Electronic Publication: 2024 Jan 03. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Royal Society of Chemistry Country of Publication: England NLM ID: 101598493 Publication Model: Electronic Cited Medium: Internet ISSN: 2050-7518 (Electronic) Linking ISSN: 2050750X NLM ISO Abbreviation: J Mater Chem B Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Cambridge : Royal Society of Chemistry |
| مواضيع طبية MeSH: | Osteogenesis* , Polyglactin 910*/chemistry, Humans ; Polylactic Acid-Polyglycolic Acid Copolymer ; Calcium Sulfate ; Polyglycolic Acid/chemistry ; Lactic Acid/chemistry ; Arginine/pharmacology ; Biocompatible Materials/pharmacology ; Biocompatible Materials/chemistry |
| مستخلص: | Poly(lactide- co -glycolide) (PLGA) and calcium sulfate composites are promising biodegradable biomaterials but are still challenging to use in people with high levels of blood glucose or diabetes. To date, the influence of glucose on their degradation has not yet been elucidated and thus calls for more research attention. Herein, a novel calcium sulfate whisker with L-arginine was used to effectively tune its crystal morphology and was employed as a reinforced phase to construct the PLGA-based composite scaffolds (ArgCSH/PLGA) with a sleeve porous structure. ArgCSH/PLGA showed excellent elastic modulus and strength in the compression and bending models. Moreover, an in vitro immersion test showed that ArgCSH/PLGA possessed degradation and redeposition behaviors sensitive to glucose concentration, and the adsorbed Arg played a crucial role in the degradation process. The subsequent cell functional evaluation showed that ArgCSH could effectively protect cells from damage caused by AGEs and promote osteogenic differentiation. The corresponding degradation products of ArgCSH/PLGA displayed the ability to regulate osteoblast bone differentiation and accelerate matrix mineralization. These findings provide new insights into the interaction between biomaterials and the physiological environment, which may be useful in expanding the targeted choice of efficient bone graft biodegradable materials for diabetic osteoporosis. |
| المشرفين على المادة: | 1SIA8062RS (Polylactic Acid-Polyglycolic Acid Copolymer) 34346-01-5 (Polyglactin 910) WAT0DDB505 (Calcium Sulfate) 26009-03-0 (Polyglycolic Acid) 33X04XA5AT (Lactic Acid) 94ZLA3W45F (Arginine) 0 (Biocompatible Materials) |
| تواريخ الأحداث: | Date Created: 20231218 Date Completed: 20240105 Latest Revision: 20240105 |
| رمز التحديث: | 20240105 |
| DOI: | 10.1039/d3tb01595e |
| PMID: | 38108579 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 2050-7518 |
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| DOI: | 10.1039/d3tb01595e |