دورية أكاديمية
أعرض في EDS

Adjuvant and neoadjuvant therapies for hepatocellular carcinoma.

التفاصيل البيبلوغرافية
العنوان: Adjuvant and neoadjuvant therapies for hepatocellular carcinoma.
المؤلفون: Vogel A; Department of Gastroenterology and Hepatology, Toronto General Hospital, Toronto, ON, Canada.; Department of Medical Oncology, Princess Margaret Cancer Centre, Toronto, ON, Canada.; Department of Gastroenterology, Hepatology, Infectiology and Endocrinology, Hannover Medical School, Hannover, Germany., Grant RC; Department of Medical Oncology, Princess Margaret Cancer Centre, Toronto, ON, Canada.; Institute of Medical Science, University of Toronto, Toronto, ON, Canada., Meyer T; Research Department of Oncology, UCL Cancer Institute, University College London, London, UK.; Royal Free Hospital, London, UK., Sapisochin G; Department of Abdominal Transplant & HPB Surgical Oncology, University Health Network, University of Toronto, Toronto, ON, Canada., O'Kane GM; Trinity St. James's Cancer Institute, St. James's Hospital, Dublin, Ireland., Saborowski A; Department of Gastroenterology, Hepatology, Infectiology and Endocrinology, Hannover Medical School, Hannover, Germany.
المصدر: Hepatology (Baltimore, Md.) [Hepatology] 2023 Dec 18. Date of Electronic Publication: 2023 Dec 18.
Publication Model: Ahead of Print
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Wolters Kluwer Health, Inc Country of Publication: United States NLM ID: 8302946 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1527-3350 (Electronic) Linking ISSN: 02709139 NLM ISO Abbreviation: Hepatology Subsets: MEDLINE
أسماء مطبوعة: Publication: 2023- : [Philadelphia] : Wolters Kluwer Health, Inc.
Original Publication: Baltimore, MD : Williams & Wilkins, [c1981]-
مستخلص: Immune-oncology-based regimens have shown efficacy in advanced HCC and have been implemented as standard of care as first-line therapy. Their efficacy, including high response rates, and safety justify their evaluation in earlier disease stages. Following negative results for adjuvant sorafenib in the global STORM trial in 2015, 4 global phase 3 trials, featuring different immune checkpoint inhibitor combinations, entered in parallel the race in the adjuvant setting. The IMbrave050 trial, comparing adjuvant atezolizumab in combination with bevacizumab to active surveillance following curative-intent resection or ablation, was the first to report, fast-tracking the results of the first interim analysis and demonstrating an improvement in recurrence-free survival. The trial has provoked a discussion on the horizon of expectations from adjuvant treatment and the clinical relevance of efficacy endpoints. Moreover, major pathological responses reported from early phase 2 data in the neoadjuvant setting provide a strong rationale for the evaluation of these concepts in phase 3 trials. In this review, we summarize current evidence and outline future directions for systemic therapies in early-stage HCC.
(Copyright © 2023 American Association for the Study of Liver Diseases.)
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تواريخ الأحداث: Date Created: 20231218 Latest Revision: 20240301
رمز التحديث: 20240301
DOI: 10.1097/HEP.0000000000000726
PMID: 38108634
قاعدة البيانات: MEDLINE
الوصف
تدمد:1527-3350
DOI:10.1097/HEP.0000000000000726