دورية أكاديمية
أعرض في EDS

On the Mechanisms of the Cardiotoxic Effect of Lead Oxide Nanoparticles.

التفاصيل البيبلوغرافية
العنوان: On the Mechanisms of the Cardiotoxic Effect of Lead Oxide Nanoparticles.
المؤلفون: Minigaliyeva IA; Yekaterinburg Medical Research Center for Prophylaxis and Health Protection in Industrial Workers, Yekaterinburg, Russian Federation, 620014.; Laboratory of Stochastic Transport of Nanoparticles in Living Systems, Ural Federal University, Yekaterinburg, Russian Federation, 620000., Klinova SV; Yekaterinburg Medical Research Center for Prophylaxis and Health Protection in Industrial Workers, Yekaterinburg, Russian Federation, 620014., Sutunkova MP; Yekaterinburg Medical Research Center for Prophylaxis and Health Protection in Industrial Workers, Yekaterinburg, Russian Federation, 620014., Ryabova YV; Yekaterinburg Medical Research Center for Prophylaxis and Health Protection in Industrial Workers, Yekaterinburg, Russian Federation, 620014.; Laboratory of Stochastic Transport of Nanoparticles in Living Systems, Ural Federal University, Yekaterinburg, Russian Federation, 620000., Valamina IE; Ural State Medical University, Yekaterinburg, Russian Federation, 620109., Shelomentsev IG; Yekaterinburg Medical Research Center for Prophylaxis and Health Protection in Industrial Workers, Yekaterinburg, Russian Federation, 620014., Shtin TN; Yekaterinburg Medical Research Center for Prophylaxis and Health Protection in Industrial Workers, Yekaterinburg, Russian Federation, 620014., Bushueva TV; Yekaterinburg Medical Research Center for Prophylaxis and Health Protection in Industrial Workers, Yekaterinburg, Russian Federation, 620014., Protsenko YL; Institute of Immunology and Physiology, Ural Branch of the Russian Academy of Sciences, Yekaterinburg, Russian Federation, 620049., Balakin AA; Institute of Immunology and Physiology, Ural Branch of the Russian Academy of Sciences, Yekaterinburg, Russian Federation, 620049., Lisin RV; Institute of Immunology and Physiology, Ural Branch of the Russian Academy of Sciences, Yekaterinburg, Russian Federation, 620049., Kuznetsov DA; Institute of Immunology and Physiology, Ural Branch of the Russian Academy of Sciences, Yekaterinburg, Russian Federation, 620049., Katsnelson BA; Yekaterinburg Medical Research Center for Prophylaxis and Health Protection in Industrial Workers, Yekaterinburg, Russian Federation, 620014., Toropova LV; Laboratory of Mathematical Modeling of Physical and Chemical Processes in Multiphase Media, Ural Federal University, Yekaterinburg, Russian Federation, 620000. liubov.toropova@uni-jena.de.; Otto-Schott-Institut für Materialforschung, Friedrich-Schiller-Universität-Jena, 07743, Jena, Germany. liubov.toropova@uni-jena.de.
المصدر: Cardiovascular toxicology [Cardiovasc Toxicol] 2024 Jan; Vol. 24 (1), pp. 49-61. Date of Electronic Publication: 2023 Dec 18.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Humana Press Country of Publication: United States NLM ID: 101135818 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1559-0259 (Electronic) Linking ISSN: 15307905 NLM ISO Abbreviation: Cardiovasc Toxicol Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Totowa, NJ : Humana Press, c2001-
مواضيع طبية MeSH: Lead* , Nanoparticles*/toxicity, Rats ; Male ; Animals ; Oxides/toxicity ; Oxides/chemistry ; Oxidative Stress
مستخلص: Lead compounds are one of the most common pollutants of the workplace air and the environment. In the occupational setting, the sources of their emission, including in nanoscale form, are various technological processes associated with lead smelting and handling of non-ferrous metals and their alloys, the production of copper and batteries. Both lead poisoning and lead exposure without obvious signs of poisoning have a detrimental effect on the cardiovascular system. The purpose of this research was to investigate the mechanisms of the cardiotoxic effect of lead oxide nanoparticles (PbO NPs). The toxicological experiment involved male albino rats subchronically exposed to PbO NPs (49.6 ± 16.0 nm in size) instilled intraperitoneally in a suspension. We then assessed post-exposure hematological and biochemical parameters of blood and urine, histological and ultrastructural changes in cardiomyocytes, and non-invasively recorded electrocardiograms and blood pressure parameters in the rodents. Myocardial contractility was studied on isolated preparations of cardiac muscles. We established that PbO NPs induced oxidative stress and damage to the ultrastructure of cardiomyocytes, and decreased efficiency of the contractile function of the myocardium and blood pressure parameters. We also revealed such specific changes in the organism of the exposed rats as anemia, hypoxia, and hypocalcemia.
(© 2023. The Author(s).)
References: Arkh Anat Gistol Embriol. 1969 May;56(5):85-91. (PMID: 4189974)
Biomed Pharmacother. 2021 May;137:111324. (PMID: 33592547)
J Bone Miner Res. 2010 Jun;25(6):1441-5. (PMID: 20200937)
Am J Epidemiol. 2001 Mar 15;153(6):537-45. (PMID: 11257061)
J Nutr. 1992 Jul;122(7):1351-60. (PMID: 1619463)
Front Physiol. 2021 Jan 07;11:590308. (PMID: 33488395)
Biol Trace Elem Res. 2015 Oct;167(2):280-7. (PMID: 25795172)
Food Chem Toxicol. 2019 Nov;133:110753. (PMID: 31400477)
PLoS One. 2011 Apr 11;6(4):e18730. (PMID: 21494558)
Occup Med (Lond). 2015 Jul;65(5):348-56. (PMID: 26187801)
Environ Health Perspect. 2007 Mar;115(3):472-82. (PMID: 17431501)
Int J Mol Sci. 2015 Sep 17;16(9):22555-83. (PMID: 26393577)
Int Immunopharmacol. 2004 Aug;4(8):1039-49. (PMID: 15222978)
Med Lav. 2012 Mar-Apr;103(2):146-59. (PMID: 22619991)
PLoS One. 2011 Feb 25;6(2):e17117. (PMID: 21364929)
Int J Mol Sci. 2014 Nov 24;15(11):21538-53. (PMID: 25421246)
Life Sci. 2000 Dec 15;68(4):401-15. (PMID: 11205890)
Int J Prev Med. 2013 Jun;4(6):624-30. (PMID: 23930179)
Circ Res. 1990 Oct;67(4):893-901. (PMID: 2208612)
PLoS One. 2014 May 19;9(5):e96900. (PMID: 24841481)
Oxid Med Cell Longev. 2016;2016:7432797. (PMID: 27738491)
Lipids Health Dis. 2005 Sep 28;4:19. (PMID: 16191200)
Ann Occup Hyg. 2010 Jul;54(5):504-13. (PMID: 20403942)
Med Lav. 2009 Nov-Dec;100(6):455-70. (PMID: 20359138)
Toxicol Sci. 2011 Jan;119(1):84-92. (PMID: 20929984)
Blood Purif. 2011;31(1-3):189-96. (PMID: 21228589)
Tohoku J Exp Med. 2021;253(1):69-76. (PMID: 33473064)
Biomed Res Int. 2018 Mar 28;2018:4627391. (PMID: 29789795)
Immunopharmacology. 1999 Oct 15;44(1-2):105-10. (PMID: 10604532)
Int J Occup Environ Health. 2010 Oct-Dec;16(4):508-24. (PMID: 21222393)
Dose Response. 2020 Mar 20;18(1):1559325820914180. (PMID: 32231470)
Environ Sci Pollut Res Int. 2015 Jan;22(1):293-304. (PMID: 25062547)
Epidemiology. 2006 Sep;17(5):538-44. (PMID: 16906055)
Free Radic Biol Med. 2014 Feb;67:366-76. (PMID: 24308934)
Pharmacol Toxicol. 2001 Dec;89(6):326-30. (PMID: 11903960)
Curr Opin Toxicol. 2020 Feb;19:112-120. (PMID: 32566805)
Drug Chem Toxicol. 2022 Mar;45(2):589-593. (PMID: 32126859)
Environ Sci Pollut Res Int. 2021 Jun;28(23):28833-28847. (PMID: 33840028)
Neurotox Res. 2020 Apr;37(4):857-870. (PMID: 31997153)
Int J Mol Sci. 2020 Jan 21;21(3):. (PMID: 31973040)
Environ Res. 2021 Apr;195:110827. (PMID: 33549618)
Life Sci. 2017 Jul 1;180:93-101. (PMID: 28499935)
Annu Rev Pathol. 2006;1:297-329. (PMID: 18039117)
Sci Rep. 2022 Nov 14;12(1):19444. (PMID: 36376368)
Toxicol Rep. 2021 Nov 30;8:1970-1978. (PMID: 34934635)
Toxicology. 2017 Apr 1;380:72-93. (PMID: 28212817)
Int J Environ Res Public Health. 2020 Jun 18;17(12):. (PMID: 32570851)
Am J Physiol Heart Circ Physiol. 2008 Aug;295(2):H454-65. (PMID: 18567711)
Int J Mol Sci. 2014 Jul 14;15(7):12379-406. (PMID: 25026171)
Toxic Rep Ser. 2020 Jul;(87):. (PMID: 33529180)
Epidemiology. 2003 Jan;14(1):30-6. (PMID: 12500043)
Int J Mol Sci. 2021 Mar 27;22(7):. (PMID: 33801669)
Cardiovasc Toxicol. 2017 Apr;17(2):190-199. (PMID: 27272938)
Int J Mol Sci. 2013 Jan 25;14(2):2449-83. (PMID: 23354478)
معلومات مُعتمدة: Ural Federal University Program of Development within the Priority-2030 Program Ministry of Science and Higher Education of the Russian Federation
فهرسة مساهمة: Keywords: Cardiotoxicity; Experimental study; Nanoparticles; Rats
المشرفين على المادة: 4IN6FN8492 (lead oxide)
2P299V784P (Lead)
0 (Oxides)
تواريخ الأحداث: Date Created: 20231218 Date Completed: 20240205 Latest Revision: 20240206
رمز التحديث: 20240206
مُعرف محوري في PubMed: PMC10838250
DOI: 10.1007/s12012-023-09814-5
PMID: 38108959
قاعدة البيانات: MEDLINE
الوصف
تدمد:1559-0259
DOI:10.1007/s12012-023-09814-5