دورية أكاديمية
Interaction between the EPHB2 receptor and EFNB1 ligand drives gastric cancer invasion and metastasis via the Wnt/β-catenin/FAK pathway.
| العنوان: | Interaction between the EPHB2 receptor and EFNB1 ligand drives gastric cancer invasion and metastasis via the Wnt/β-catenin/FAK pathway. |
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| المؤلفون: | Hu Y; Division of Cancer Biology, Laboratory Animal Center, The Fourth Military Medical University, Xi'an, Shaanxi 710032, China; Department of Pathology, Affiliated Hospital of Yan'an University, Yanan, Shaanxi 716000, China., Xie Q; Division of Cancer Biology, Laboratory Animal Center, The Fourth Military Medical University, Xi'an, Shaanxi 710032, China., Zhao J; School of Basic Medical Sciences, Medical College of Yan'an University, 580 Bao-Ta Street, Yanan, Shaanxi 716000, China., Yang R; Gansu University of traditional Chinese Medicine, Lanzhou, Gansu 730030, China., Qin J; Division of Cancer Biology, Laboratory Animal Center, The Fourth Military Medical University, Xi'an, Shaanxi 710032, China., Li H; Division of Cancer Biology, Laboratory Animal Center, The Fourth Military Medical University, Xi'an, Shaanxi 710032, China., Zhao Y; Division of Cancer Biology, Laboratory Animal Center, The Fourth Military Medical University, Xi'an, Shaanxi 710032, China., Du X; Department of Pathology, Affiliated Hospital of Yan'an University, Yanan, Shaanxi 716000, China. Electronic address: labani4@fmmu.edu.cn., Shi C; Division of Cancer Biology, Laboratory Animal Center, The Fourth Military Medical University, Xi'an, Shaanxi 710032, China. Electronic address: changhong@fmmu.edu.cn. |
| المصدر: | International journal of biological macromolecules [Int J Biol Macromol] 2024 Feb; Vol. 258 (Pt 1), pp. 128848. Date of Electronic Publication: 2023 Dec 17. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Country of Publication: Netherlands NLM ID: 7909578 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0003 (Electronic) Linking ISSN: 01418130 NLM ISO Abbreviation: Int J Biol Macromol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Amsterdam : Elsevier Original Publication: Guildford, Eng., IPC Science and Technology Press. |
| مواضيع طبية MeSH: | Receptor, EphB2*/genetics , Receptor, EphB2*/metabolism , Stomach Neoplasms*/pathology, Humans ; Ephrin-B1/genetics ; Ephrin-B1/metabolism ; beta Catenin/metabolism ; Ligands ; Wnt Signaling Pathway ; Cell Movement/genetics ; Cell Line, Tumor ; Gene Expression Regulation, Neoplastic ; Cell Proliferation/genetics |
| مستخلص: | The survival benefit for patients with gastric cancer (GC) is modest due to its high transfer potential. Targeted therapy for metastasis-related genes in GC may be a viable approach, however, inhibitors specifically targeting GC are limited. In this study, GC patient-derived xenografts (PDX) with metastatic burden were established via orthotopic transplantation. PCR-Array analysis of primary and metastatic tumors revealed EPH receptor B2 (EPHB2) as the most significantly upregulated gene. The interaction between the EPHB2 receptor and its cognate-specific EFNB1 ligands was high in GC and correlated with a poor prognosis. Fc-EFNB1 treatment increased the invasion and migration abilities of GC cells and induced a high EPHB2 expression. EPHB2 knockdown in GC cells completely abolished the ephrin ligand-induced effects on invasion and migration abilities. Signal transduction analysis revealed Wnt/β-catenin and FAK as downstream signaling mediators potentially inducing the EPHB2 phenotype. In conclusion, the observed deregulation of EPHB2/EFNB1 expression in GC enhances the invasive phenotype, suggesting a potential role of EPHB2/EFNB1 compound in local tumor cell invasion and the formation of metastasis. Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. (Copyright © 2023. Published by Elsevier B.V.) |
| فهرسة مساهمة: | Keywords: EFNB1; EPHB2; Gastric cancer; Interaction; Invasion; Metastasis |
| المشرفين على المادة: | EC 2.7.10.1 (Receptor, EphB2) 0 (Ephrin-B1) 0 (beta Catenin) 0 (Ligands) 0 (EFNB1 protein, human) |
| تواريخ الأحداث: | Date Created: 20231219 Date Completed: 20240208 Latest Revision: 20240208 |
| رمز التحديث: | 20240208 |
| DOI: | 10.1016/j.ijbiomac.2023.128848 |
| PMID: | 38114003 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1879-0003 |
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| DOI: | 10.1016/j.ijbiomac.2023.128848 |