دورية أكاديمية
أعرض في EDS

Senescent skeletal muscle fibroadipogenic progenitors recruit and promote M2 polarization of macrophages.

التفاصيل البيبلوغرافية
العنوان: Senescent skeletal muscle fibroadipogenic progenitors recruit and promote M2 polarization of macrophages.
المؤلفون: Zhang X; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, Minnesota, USA.; Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, Minnesota, USA.; Paul F. Glenn Center for Biology of Aging Research at Mayo Clinic, Rochester, Minnesota, USA., Ng YE; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, Minnesota, USA., Chini LCS; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, Minnesota, USA., Heeren AA; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, Minnesota, USA., White TA; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, Minnesota, USA., Li H; Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, Minnesota, USA., Huang H; Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, Minnesota, USA., Doolittle ML; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, Minnesota, USA.; Division of Endocrinology, Mayo Clinic, Rochester, Minnesota, USA., Khosla S; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, Minnesota, USA.; Division of Endocrinology, Mayo Clinic, Rochester, Minnesota, USA., LeBrasseur NK; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, Minnesota, USA.; Paul F. Glenn Center for Biology of Aging Research at Mayo Clinic, Rochester, Minnesota, USA.; Department of Physical Medicine and Rehabilitation, Mayo Clinic, Rochester, Minnesota, USA.
المصدر: Aging cell [Aging Cell] 2024 Mar; Vol. 23 (3), pp. e14069. Date of Electronic Publication: 2023 Dec 19.
نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Wiley-Blackwell Country of Publication: England NLM ID: 101130839 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1474-9726 (Electronic) Linking ISSN: 14749718 NLM ISO Abbreviation: Aging Cell Subsets: MEDLINE
أسماء مطبوعة: Publication: Oxford, UK : Wiley-Blackwell
Original Publication: Oxford, UK : Blackwell Pub., c2002-
مواضيع طبية MeSH: Muscle, Skeletal*/metabolism , Macrophages*, Mice ; Animals ; Cell Differentiation/physiology
مستخلص: Senescent cells compromise tissue structure and function in older organisms. We recently identified senescent fibroadipogenic progenitors (FAPs) with activated chemokine signaling pathways in the skeletal muscle of old mice, and hypothesized these cells may contribute to the age-associated accumulation of immune cells in skeletal muscle. In this study, through cell-cell communication analysis of skeletal muscle single-cell RNA-sequencing data, we identified unique interactions between senescent FAPs and macrophages, including those mediated by Ccl2 and Spp1. Using mouse primary FAPs in vitro, we verified increased expression of Ccl2 and Spp1 and secretion of their respective proteins in the context of both irradiation- and etoposide-induced senescence. Compared to non-senescent FAPs, the medium of senescent FAPs markedly increased the recruitment of macrophages in an in vitro migration assay, an effect that was mitigated by preincubation with antibodies to either CCL2 or osteopontin (encoded by Spp1). Further studies demonstrated that the secretome of senescent FAPs promotes polarization of macrophages toward an M2 subtype. These data suggest the unique secretome of senescent FAPs may compromise skeletal muscle homeostasis by recruiting and directing the behavior of macrophages.
(© 2023 The Authors. Aging Cell published by Anatomical Society and John Wiley & Sons Ltd.)
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معلومات مُعتمدة: P01 AG062413 United States AG NIA NIH HHS; R01 AG076515 United States AG NIA NIH HHS; AG062413 United States AG NIA NIH HHS
فهرسة مساهمة: Keywords: cellular senescence; fibroadipogenic progenitors (FAPs); macrophages; migration; polarization
تواريخ الأحداث: Date Created: 20231220 Date Completed: 20240313 Latest Revision: 20240708
رمز التحديث: 20240709
مُعرف محوري في PubMed: PMC10928562
DOI: 10.1111/acel.14069
PMID: 38115574
قاعدة البيانات: MEDLINE
الوصف
تدمد:1474-9726
DOI:10.1111/acel.14069