دورية أكاديمية
Cytokines profile in pure neural leprosy.
| العنوان: | Cytokines profile in pure neural leprosy. |
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| المؤلفون: | Pitta IJR; Leprosy Laboratory, Oswaldo Cruz Institute, Fiocruz, Rio de Janeiro, Brazil.; Department of Neurology, Antonio Pedro University Hospital/Fluminense Federal University, Niteroi, Brazil., Angst DBM; Leprosy Laboratory, Oswaldo Cruz Institute, Fiocruz, Rio de Janeiro, Brazil., Pinheiro RO; Leprosy Laboratory, Oswaldo Cruz Institute, Fiocruz, Rio de Janeiro, Brazil., Vieira JSDS; Leprosy Laboratory, Oswaldo Cruz Institute, Fiocruz, Rio de Janeiro, Brazil., Spitz CN; Leprosy Laboratory, Oswaldo Cruz Institute, Fiocruz, Rio de Janeiro, Brazil.; Post-Graduate Program in Neurology, Federal University of the State of Rio de Janeiro, Rio de Janeiro, Rio de Janeiro, Brazil.; Department of Neurology, Pedro Ernesto University Hospital/Rio de Janeiro State University, Rio de Janeiro, Rio de Janeiro, Brazil., Andrade LR; Leprosy Laboratory, Oswaldo Cruz Institute, Fiocruz, Rio de Janeiro, Brazil.; Post-Graduate Program in Neurology, Federal University of the State of Rio de Janeiro, Rio de Janeiro, Rio de Janeiro, Brazil.; Department of Neurology, Pedro Ernesto University Hospital/Rio de Janeiro State University, Rio de Janeiro, Rio de Janeiro, Brazil., Carvalho LB; Leprosy Laboratory, Oswaldo Cruz Institute, Fiocruz, Rio de Janeiro, Brazil.; Post-Graduate Program in Neurology, Federal University of the State of Rio de Janeiro, Rio de Janeiro, Rio de Janeiro, Brazil.; Department of Neurology, Pedro Ernesto University Hospital/Rio de Janeiro State University, Rio de Janeiro, Rio de Janeiro, Brazil., Hacker MA; Leprosy Laboratory, Oswaldo Cruz Institute, Fiocruz, Rio de Janeiro, Brazil., Sarno EN; Leprosy Laboratory, Oswaldo Cruz Institute, Fiocruz, Rio de Janeiro, Brazil., Jardim MR; Leprosy Laboratory, Oswaldo Cruz Institute, Fiocruz, Rio de Janeiro, Brazil.; Post-Graduate Program in Neurology, Federal University of the State of Rio de Janeiro, Rio de Janeiro, Rio de Janeiro, Brazil.; Department of Neurology, Pedro Ernesto University Hospital/Rio de Janeiro State University, Rio de Janeiro, Rio de Janeiro, Brazil. |
| المصدر: | Frontiers in immunology [Front Immunol] 2023 Dec 05; Vol. 14, pp. 1272471. Date of Electronic Publication: 2023 Dec 05 (Print Publication: 2023). |
| نوع المنشور: | Journal Article; Comment |
| اللغة: | English |
| بيانات الدورية: | Publisher: Frontiers Research Foundation] Country of Publication: Switzerland NLM ID: 101560960 Publication Model: eCollection Cited Medium: Internet ISSN: 1664-3224 (Electronic) Linking ISSN: 16643224 NLM ISO Abbreviation: Front Immunol Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: [Lausanne : Frontiers Research Foundation] |
| مواضيع طبية MeSH: | Leprosy, Tuberculoid*/diagnosis , Leprosy, Tuberculoid*/pathology , Leprosy* , Neuritis*, Humans ; Cytokines ; Interleukin-10 ; Interleukin-17 ; Chemokine CXCL10 ; Transforming Growth Factor beta |
| مستخلص: | Introduction: Pure Neural Leprosy (PNL) is a form of this long time known disease that affects only the peripheral nervous system. Since it is a rare form of the disease, its pathophisiology is still poorly understood. Objective: Describe the cytokines profile in patients with PNL. Methods: 30 Patients diagnosed with PNL in the Souza Araujo Outpatient Clinic and with cytokines evaluated were selected. They were evaluated by neurologists and diagnosed after a nerve biopsy. Serum levels of IL-1 β, IL-6, IL-10, IL-17, TNF, CCL-2/MCP-1, IFN-ϒ, CXCL-10/IP-10 and TGF-β were evaluates at the moment of the diagnosis. Results: Neural thickening was a common clinical finding in this groups of patients. Small and medium sensitive fibers signs and symptoms were present in 92% of the patients and motor involvement in 53%. 43% of patients presented neuropathic pain and no one had neuritis TGF-beta, IL-17, CCl-2 and IP-10. CCL-2 levels were associated with demyelinating patters and IP-10 and IL-1o were associated with axonal patterns at NCS. Discussion: PNL patients' cytokine profile appears to be different of other clinical forms of leprosy, with the presence of cytokines described in both tuberculoid and lepromatous leprosy. High levels of CCl-2 may be related to the presence of silent neuritis as well as the presence of IL-10. PNL is unique a form of leprosy, therefore, understanding its immunological profiles essential to better understand the disease itself. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2023 Pitta, Angst, Pinheiro, Vieira, Spitz, Andrade, Carvalho, Hacker, Sarno and Jardim.) |
| التعليقات: | Comment on: Front Immunol. 2020 Jan 24;11:23. (PMID: 32038662) |
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| فهرسة مساهمة: | Keywords: cytokine profile; leprosy nerve conduction studies; leprosy neuropathy; leprosy reactions; pure neural leprosy |
| المشرفين على المادة: | 0 (Cytokines) 130068-27-8 (Interleukin-10) 0 (Interleukin-17) 0 (Chemokine CXCL10) 0 (Transforming Growth Factor beta) |
| تواريخ الأحداث: | Date Created: 20231220 Date Completed: 20231221 Latest Revision: 20240325 |
| رمز التحديث: | 20240325 |
| مُعرف محوري في PubMed: | PMC10728593 |
| DOI: | 10.3389/fimmu.2023.1272471 |
| PMID: | 38116016 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1664-3224 |
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| DOI: | 10.3389/fimmu.2023.1272471 |