دورية أكاديمية
أعرض في EDS

Socioeconomic representativeness of Australian, Canadian and British cohorts from the paediatric diabetes AdDIT study: comparisons to regional and national data.

التفاصيل البيبلوغرافية
العنوان: Socioeconomic representativeness of Australian, Canadian and British cohorts from the paediatric diabetes AdDIT study: comparisons to regional and national data.
المؤلفون: Mahmud FH; Division of Endocrinology, Department of Paediatrics, The Hospital for Sick Children and University of Toronto, 555 University Avenue, RM 5446 Black Wing, Toronto, ON, M5G 1X8, Canada. farid.mahmud@sickkids.ca., Clarke ABM; Division of Endocrinology, Department of Paediatrics, The Hospital for Sick Children and University of Toronto, 555 University Avenue, RM 5446 Black Wing, Toronto, ON, M5G 1X8, Canada., Elia Y; Division of Endocrinology, Department of Paediatrics, The Hospital for Sick Children and University of Toronto, 555 University Avenue, RM 5446 Black Wing, Toronto, ON, M5G 1X8, Canada., Curtis J; Division of Endocrinology, Department of Paediatrics, The Hospital for Sick Children and University of Toronto, 555 University Avenue, RM 5446 Black Wing, Toronto, ON, M5G 1X8, Canada., Benitez-Aguirre P; Institute of Endocrinology and Diabetes, The Children's Hospital at Westmead, University of Sydney, Sydney, Australia., Cameron FJ; Department of Paediatrics, University of Melbourne, Melbourne, Australia., Chiesa ST; Institute of Cardiovascular Science, University College London, London, UK., Clarson C; London Health Sciences Center, London, ON, Canada., Couper JJ; Departments of Endocrinology and Diabetes and Medical Imaging, Women's and Children's Hospital, Adelaide, Australia., Craig ME; Institute of Endocrinology and Diabetes, The Children's Hospital at Westmead, University of Sydney, Sydney, Australia.; Discipline of Paediatrics & Child Health, School of Clinical Medicine, University of New South Wales Medicine & Health, Sydney, Australia., Dalton RN; Evelina London Children's Hospital, Guy's and St Thomas' NHS Foundation Trust, London, UK., Daneman D; Division of Endocrinology, Department of Paediatrics, The Hospital for Sick Children and University of Toronto, 555 University Avenue, RM 5446 Black Wing, Toronto, ON, M5G 1X8, Canada., Davis EA; Telethon Kids Institute, University of Western Australia, Perth, Australia., Deanfield JE; Institute of Cardiovascular Science, University College London, London, UK., Donaghue KC; Institute of Endocrinology and Diabetes, The Children's Hospital at Westmead, University of Sydney, Sydney, Australia., Jones TW; Telethon Kids Institute, University of Western Australia, Perth, Australia., Marshall SM; Faculty of Clinical Medical Sciences, Diabetes Research Group, Translational and Clinical Research Institute, Newcastle University, 4Th Floor William Leech Building, Framlington Place, Newcastle Upon Tyne, UK., Neil A; Oxford Centre for Diabetes, Endocrinology & Metabolism, University of Oxford, Oxford, UK., Marcovecchio ML; Department of Paediatrics, University of Cambridge, Cambridge, UK.
المصدر: BMC medicine [BMC Med] 2023 Dec 20; Vol. 21 (1), pp. 506. Date of Electronic Publication: 2023 Dec 20.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: BioMed Central Country of Publication: England NLM ID: 101190723 Publication Model: Electronic Cited Medium: Internet ISSN: 1741-7015 (Electronic) Linking ISSN: 17417015 NLM ISO Abbreviation: BMC Med Subsets: MEDLINE
أسماء مطبوعة: Original Publication: [London] : BioMed Central, 2003-
مواضيع طبية MeSH: Diabetes Mellitus, Type 1*/epidemiology , Diabetes Mellitus, Type 1*/therapy, Adolescent ; Humans ; Australia/epidemiology ; Canada/epidemiology ; Clinical Trials as Topic ; Cross-Sectional Studies ; Retrospective Studies ; Socioeconomic Factors
مستخلص: Background: Given limited data regarding the involvement of disadvantaged groups in paediatric diabetes clinical trials, this study aimed to evaluate the socioeconomic representativeness of participants recruited into a multinational clinical trial in relation to regional and national type 1 diabetes reference populations.
Methods: Retrospective, cross-sectional evaluation of a subset of adolescent type 1 diabetes cardiorenal intervention trial (AdDIT) participants from Australia (n = 144), Canada (n = 312) and the UK (n = 173). Validated national measures of deprivation were used: the Index of Relative Socioeconomic Disadvantage (IRSD) 2016 (Australia), the Material Resources (MR) dimension of the Canadian Marginalisation index 2016 (Canada) and the Index of Multiple Deprivation (IMD) 2015 (UK). Representativeness was assessed by comparing the AdDIT cohort's distribution of deprivation quintiles with that of the local paediatric type 1 diabetes population (regional), and the broader type 1 diabetes population for which the trial's intervention was targeted (national).
Results: Recruited study cohorts from each country had higher proportions of participants with higher SES, and significant underrepresentation of lower SES, in relation to their national references. The socioeconomic make-up in Australia mirrored that of the regional population (p = 0.99). For Canada, the 2nd least deprived (p = 0.001) and the most deprived quintiles (p < 0.001) were over- and under-represented relative to the regional reference, while the UK featured higher regional and national SES bias with over-representation and under-representation from the least-deprived and most-deprived quintiles (p < 0.0001).
Conclusions: Significant national differences in trial participation of low SES participants were observed, highlighting limitations in access to clinical research and the importance of reporting sociodemographic representation in diabetes clinical trials.
Trial Registration: NCT01581476. Registered on 20 April 2012.
(© 2023. The Author(s).)
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فهرسة مساهمة: Keywords: Clinical trial; Deprivation; Marginalization; Multicenter trials; Paediatric; Socioeconomic status; Type 1 diabetes
سلسلة جزيئية: ClinicalTrials.gov NCT01581476
تواريخ الأحداث: Date Created: 20231221 Date Completed: 20240112 Latest Revision: 20240212
رمز التحديث: 20240213
مُعرف محوري في PubMed: PMC10734126
DOI: 10.1186/s12916-023-03222-w
PMID: 38124088
قاعدة البيانات: MEDLINE
الوصف
تدمد:1741-7015
DOI:10.1186/s12916-023-03222-w