دورية أكاديمية
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A network approach to the investigation of childhood irritability: probing frustration using social stimuli.

التفاصيل البيبلوغرافية
العنوان: A network approach to the investigation of childhood irritability: probing frustration using social stimuli.
المؤلفون: Thompson KI; Department of Psychiatry, Washington University in St Louis School of Medicine, St Louis, MO, USA., Schneider CJ; Department of Psychiatry, Washington University in St Louis School of Medicine, St Louis, MO, USA., Lopez-Roque JA; Department of Psychiatry, Washington University in St Louis School of Medicine, St Louis, MO, USA., Wakschlag LS; Department of Medical Social Sciences, Northwestern University, Feinberg School of Medicine, Chicago, IL, USA., Karim HT; Department of Psychiatry, University of Pittsburg School of Medicine, Pittsburgh, PA, USA., Perlman SB; Department of Psychiatry, Washington University in St Louis School of Medicine, St Louis, MO, USA.
المصدر: Journal of child psychology and psychiatry, and allied disciplines [J Child Psychol Psychiatry] 2024 Jul; Vol. 65 (7), pp. 959-972. Date of Electronic Publication: 2023 Dec 20.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Blackwell Publishers Country of Publication: England NLM ID: 0375361 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1469-7610 (Electronic) Linking ISSN: 00219630 NLM ISO Abbreviation: J Child Psychol Psychiatry Subsets: MEDLINE
أسماء مطبوعة: Publication: 2002- : Oxford : Blackwell Publishers
Original Publication: Oxford ; New York : Pergamon Press
مواضيع طبية MeSH: Irritable Mood*/physiology , Magnetic Resonance Imaging* , Frustration* , Temperament*/physiology , Nerve Net*/diagnostic imaging , Nerve Net*/physiopathology, Humans ; Male ; Female ; Child ; Longitudinal Studies ; Anger/physiology ; Child Behavior/physiology ; Child, Preschool
مستخلص: Background: Self-regulation in early childhood develops within a social context. Variations in such development can be attributed to inter-individual behavioral differences, which can be captured both as facets of temperament and across a normal:abnormal dimensional spectrum. With increasing emphasis on irritability as a robust early-life transdiagnostic indicator of broad psychopathological risk, linkage to neural mechanisms is imperative. Currently, there is inconsistency in the identification of neural circuits that underlie irritability in children, especially in social contexts. This study aimed to address this gap by utilizing a functional magnetic resonance imaging (fMRI) paradigm to investigate pediatric anger/frustration using social stimuli.
Methods: Seventy-three children (M = 6 years, SD = 0.565) were recruited from a larger longitudinal study on irritability development. Caregivers completed questionnaires assessing irritable temperament and clinical symptoms of irritability. Children participated in a frustration task during fMRI scanning that was designed to induce frustration through loss of a desired prize to an animated character. Data were analyzed using both general linear modeling (GLM) and independent components analysis (ICA) and examined from the temperament and clinical perspectives.
Results: ICA results uncovered an overarching network structure above and beyond what was revealed by traditional GLM analyses. Results showed that greater temperamental irritability was associated with significantly diminished spatial extent of activation and low-frequency power in a network comprised of the posterior superior temporal sulcus (pSTS) and the precuneus (p < .05, FDR-corrected). However, greater severity along the spectrum of clinical expression of irritability was associated with significantly increased extent and intensity of spatial activation as well as low- and high-frequency neural signal power in the right caudate (p < .05, FDR-corrected).
Conclusions: Our findings point to specific neural circuitry underlying pediatric irritability in the context of frustration using social stimuli. Results suggest that a deliberate focus on the construction of network-based neurodevelopmental profiles and social interaction along the normal:abnormal irritability spectrum is warranted to further identify comprehensive transdiagnostic substrates of the irritability.
(© 2023 Association for Child and Adolescent Mental Health.)
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معلومات مُعتمدة: R01 MH107652 United States NH NIH HHS; R01 MH124266 United States NH NIH HHS; R01 MH124266 United States MH NIMH NIH HHS; L40 MH134646 United States MH NIMH NIH HHS; P50 HD103525 United States HD NICHD NIH HHS; R01 MH107540 United States MH NIMH NIH HHS
فهرسة مساهمة: Keywords: GLM; ICA; Irritability; frustration; socioemotional development
تواريخ الأحداث: Date Created: 20231221 Date Completed: 20240607 Latest Revision: 20240609
رمز التحديث: 20240609
مُعرف محوري في PubMed: PMC11161318
DOI: 10.1111/jcpp.13937
PMID: 38124618
قاعدة البيانات: MEDLINE
الوصف
تدمد:1469-7610
DOI:10.1111/jcpp.13937