دورية أكاديمية
Exploring the antioxidant activity of Fe(III), Mn(III)Mn(II), and Cu(II) compounds in Saccharomyces cerevisiae and Galleria mellonella models of study.
| العنوان: | Exploring the antioxidant activity of Fe(III), Mn(III)Mn(II), and Cu(II) compounds in Saccharomyces cerevisiae and Galleria mellonella models of study. |
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| المؤلفون: | Mattos LMM; Departamento de Bioquímica, Instituto de Química, Universidade Federal do Rio de Janeiro, RJ, Brazil.; Rede de Micologia RJ - FAPERJ., Hottum HM; Departamento de Bioquímica, Instituto de Química, Universidade Federal do Rio de Janeiro, RJ, Brazil.; Rede de Micologia RJ - FAPERJ., Pires DC; Departamento de Bioquímica, Instituto de Química, Universidade Federal do Rio de Janeiro, RJ, Brazil.; Rede de Micologia RJ - FAPERJ., Segat BB; Departamento de Química, Universidade Federal de Santa Catarina, Florianópolis, SC, Brazil., Horn A Jr; Departamento de Química, Universidade Federal de Santa Catarina, Florianópolis, SC, Brazil., Fernandes C; Departamento de Química, Universidade Federal de Santa Catarina, Florianópolis, SC, Brazil., Pereira MD; Departamento de Bioquímica, Instituto de Química, Universidade Federal do Rio de Janeiro, RJ, Brazil.; Rede de Micologia RJ - FAPERJ. |
| المصدر: | FEMS yeast research [FEMS Yeast Res] 2024 Jan 09; Vol. 24. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Oxford University Press Country of Publication: England NLM ID: 101085384 Publication Model: Print Cited Medium: Internet ISSN: 1567-1364 (Electronic) Linking ISSN: 15671356 NLM ISO Abbreviation: FEMS Yeast Res Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2015- : Oxford Oxford University Press Original Publication: Amsterdam ; New York : Published by Elsevier Science B.V. on behalf of Federation of European Microbiological Societies, [2001- |
| مواضيع طبية MeSH: | Antioxidants*/pharmacology , Antioxidants*/metabolism , Moths*, Animals ; Humans ; Saccharomyces cerevisiae/metabolism ; Ferric Compounds/metabolism ; Reactive Oxygen Species/metabolism ; Hydrogen Peroxide/pharmacology ; Oxidative Stress |
| مستخلص: | Reactive oxygen species (ROS) are closely related to oxidative stress, aging, and the onset of human diseases. To mitigate ROS-induced damages, extensive research has focused on examining the antioxidative attributes of various synthetic/natural substances. Coordination compounds serving as synthetic antioxidants have emerged as a promising approach to attenuate ROS toxicity. Herein, we investigated the antioxidant potential of a series of Fe(III) (1), Mn(III)Mn(II) (2) and Cu(II) (3) coordination compounds synthesized with the ligand N-(2-hydroxybenzyl)-N-(2-pyridylmethyl)[(3-chloro)(2-hydroxy)]-propylamine in Saccharomyces cerevisiae exposed to oxidative stress. We also assessed the antioxidant potential of these complexes in the alternative model of study, Galleria mellonella. DPPH analysis indicated that these complexes presented moderate antioxidant activity. However, treating Saccharomyces cerevisiae with 1, 2 and 3 increased the tolerance against oxidative stress and extended yeast lifespan. The treatment of yeast cells with these complexes decreased lipid peroxidation and catalase activity in stressed cells, whilst no change in SOD activity was observed. Moreover, these complexes induced the Hsp104 expression. In G. mellonella, complex administration extended larval survival under H2O2 stress and did not affect the insect's life cycle. Our results suggest that the antioxidant potential exhibited by these complexes could be further explored to mitigate various oxidative stress-related disorders. (© The Author(s) 2023. Published by Oxford University Press on behalf of FEMS.) |
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| معلومات مُعتمدة: | 09/2018 Conselho Nacional de Desenvolvimento Científico e Tecnológico; E-26/010001697/2019 FAPERJ; Coordenação de Aperfeiçoamento de Pessoal de Nível Superior |
| فهرسة مساهمة: | Keywords: Galleria mellonella; Saccharomyces cerevisiae; antioxidants; coordination compounds; oxidative stress |
| المشرفين على المادة: | 0 (Antioxidants) 0 (Ferric Compounds) 0 (Reactive Oxygen Species) BBX060AN9V (Hydrogen Peroxide) |
| تواريخ الأحداث: | Date Created: 20231221 Date Completed: 20240111 Latest Revision: 20240208 |
| رمز التحديث: | 20240209 |
| مُعرف محوري في PubMed: | PMC10776354 |
| DOI: | 10.1093/femsyr/foad052 |
| PMID: | 38124682 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1567-1364 |
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| DOI: | 10.1093/femsyr/foad052 |