دورية أكاديمية
أعرض في EDS

Optimization of cationic nanoparticles stabilized by poloxamer 188: A potential approach for improving the biological activity of Aloe perryi .

التفاصيل البيبلوغرافية
العنوان: Optimization of cationic nanoparticles stabilized by poloxamer 188: A potential approach for improving the biological activity of Aloe perryi .
المؤلفون: Aldayel TS; Clinical Nutrition, Department of Health Sciences, Faculty of Health and Rehabilitation Sciences, Princess Nourah bint Abdulrahman University, P.O. Box 84428, Riyadh, 11671, Saudi Arabia., Badran MM; Department of Pharmaceutics, College of Pharmacy, King Saud University, Riyadh, 11495, Saudi Arabia.; Nanobiotechnology Unit, College of Pharmacy, King Saud University, Riyadh, 11495, Saudi Arabia., Alomrani AH; Department of Pharmaceutics, College of Pharmacy, King Saud University, Riyadh, 11495, Saudi Arabia.; Nanobiotechnology Unit, College of Pharmacy, King Saud University, Riyadh, 11495, Saudi Arabia., AlFaris NA; Department of Physical Sports Sciences, College of Sports Sciences & Physical Activity, Princess Nourah bint Abdulrahman University, P.O. Box 84428, Riyadh, 11671, Saudi Arabia., Altamimi JZ; Department of Physical Sports Sciences, College of Sports Sciences & Physical Activity, Princess Nourah bint Abdulrahman University, P.O. Box 84428, Riyadh, 11671, Saudi Arabia., Alqahtani AS; Department of Pharmacognosy, College of Pharmacy, King Saud University, Riyadh, 11451, Saudi Arabia., Nasr FA; Biology Department, College of Science, Imam Mohammad Ibn Saud Islamic University (IMSIU), Riyadh, 11623, Saudi Arabia., Ghaffar S; Department of Pharmacognosy, College of Pharmacy, King Saud University, Riyadh, 11451, Saudi Arabia., Orfali R; Department of Pharmacognosy, College of Pharmacy, King Saud University, Riyadh, 11451, Saudi Arabia.
المصدر: Heliyon [Heliyon] 2023 Nov 21; Vol. 9 (12), pp. e22691. Date of Electronic Publication: 2023 Nov 21 (Print Publication: 2023).
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Elsevier Ltd Country of Publication: England NLM ID: 101672560 Publication Model: eCollection Cited Medium: Print ISSN: 2405-8440 (Print) Linking ISSN: 24058440 NLM ISO Abbreviation: Heliyon Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: London : Elsevier Ltd, [2015]-
مستخلص: Aloe perryi (AP) has gained considerable interest as a medicinal herb in various biological applications due to its rich phytochemical composition. However, the therapeutic benefits of AP could be potentiated by utilizing nanotechnology. Moreover, cationic solid lipid nanoparticles (CSLNs) possess remarkable characteristics that can greatly enrich a variety of biological uses. An optimization approach was used to achieve high-quality CSLNs to maximize the therapeutic efficacy of AP. Therefore, a factorial design was used to investigate the influence of various variables on the attributes of CSLNs quality. In this study, the factors under investigation were compritol 888 ATO (C-888, X1), poloxamer 188 (PL188, X2), and chitosan (CS, X3), which served as independent variables. The parameters measured as dependent variables included particle size (Y1), zeta potential (Y2), and encapsulation efficiency EE (Y3). The relationship among these variables was determined by Analysis of Variance (ANOVA) and response surface plots. The results revealed that PL188 played a significant role in reducing the particle size of CSLNS (ranging from 207 to 261 nm with 1 % PL188 to 167-229 nm with 3 % PL188). Conversely, an increase in the concentration of CS led to a rise in the particle size. The magnitude of positive zeta potential values was dependent on the increased concentration of CS. Moreover, the higher amounts of C-888 and PL188 improved the EE% of the CSLNs from 42 % to 86 %. Furthermore, a concentration-dependent antioxidant effect of the optimized AP-CSLNs was observed. The antioxidant activity of the optimized AP-CSLNs at 100 μg/mL was 75 % compared to 62 % and 60 % for AP-SLNs and AP solution, respectively. A similar pattern of improvement was also observed with antimicrobial, and anticancer activities of the optimized AP-CSLNs. These findings demonstrated the potential of AP-CSLNs as a carrier system, enhancing the biological activities of AP, opening new possibilities in herbal medicines.
Competing Interests: The authors declare the following financial interests/personal relationships which may be considered as potential competing interests:Tahany Saleh Aldayel reports financial support was provided by 10.13039/501100004242Princess Nourah bint Abdulrahman University. The authors declare no conflict of interest.
(© 2023 The Authors.)
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فهرسة مساهمة: Keywords: Aloe perryi; Anticancer; Antimicrobial; Antioxidant; CS; Evaluation; Nanoparticles; Optimization; SLNs
تواريخ الأحداث: Date Created: 20231221 Latest Revision: 20231222
رمز التحديث: 20231222
مُعرف محوري في PubMed: PMC10730718
DOI: 10.1016/j.heliyon.2023.e22691
PMID: 38125510
قاعدة البيانات: MEDLINE
الوصف
تدمد:2405-8440
DOI:10.1016/j.heliyon.2023.e22691