التفاصيل البيبلوغرافية
| العنوان: |
8-Methoxy-α-lapachone and lawsone: antiproliferative effects on bladder tumour cells. |
| المؤلفون: |
Ferreira GM; Programa de Pós-graduação em Ciências Farmacêuticas (CIPHARMA), Universidade Federal de Ouro Preto, Ouro Preto, Minas Gerais, Brazil., Lima APB; Programa de Pós-graduação em Ciências Farmacêuticas (CIPHARMA), Universidade Federal de Ouro Preto, Ouro Preto, Minas Gerais, Brazil., Sousa JAC; Programa de Pós-graduação em Ciências Farmacêuticas (CIPHARMA), Universidade Federal de Ouro Preto, Ouro Preto, Minas Gerais, Brazil., Pereira GR; Pontifícia Universidade Católica de Minas Gerais, PUCAQ2 Minas, Departamento de Física e Química, Instituto de Ciências Exatas e Informática ICEI, Belo Horizonte, Minas Gerais, Brazil., da Silva GN; Programa de Pós-graduação em Ciências Farmacêuticas (CIPHARMA), Universidade Federal de Ouro Preto, Ouro Preto, Minas Gerais, Brazil., Brandão GC; Programa de Pós-graduação em Ciências Farmacêuticas (CIPHARMA), Universidade Federal de Ouro Preto, Ouro Preto, Minas Gerais, Brazil. |
| المصدر: |
Natural product research [Nat Prod Res] 2023 Dec 21, pp. 1-7. Date of Electronic Publication: 2023 Dec 21. |
| Publication Model: |
Ahead of Print |
| نوع المنشور: |
Journal Article |
| اللغة: |
English |
| بيانات الدورية: |
Publisher: Taylor & Francis Health Sciences Country of Publication: England NLM ID: 101167924 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1478-6427 (Electronic) Linking ISSN: 14786419 NLM ISO Abbreviation: Nat Prod Res Subsets: MEDLINE |
| أسماء مطبوعة: |
Original Publication: Milton Park, UK : Taylor & Francis Health Sciences, c2003- |
| مستخلص: |
Quinones are chemical compounds produced from the oxidation of phenols. Among the quinones, naphthoquinones stand out as potential antitumor agents. Bladder tumour is the tenth most diagnosed in the world. Based on this, using a urothelial carcinoma cell line (T24), two naphthoquinones had their cytotoxicity tested by the MTT colorimetric method and were submitted to assays of clonogenic survival, morphology, cell cycle, cell migration and species reactive oxygen. The results showed 8-methoxy-α-lapachone and lausone presented selectivity indexes (19.5 and 28.0, respectively) for T24 cells. Moreover, the two naphthoquinones reduced the cell viability, interfered with the process of cell migration, changed the cell cycle kinectics and induced the production of species reactive oxygen (ROS). Additionaly, 8-methoxy-α-lapachone altered the morphology of the cells. In conclusion, the studied naphthoquinones showed potential antiproliferative effects in bladder cancer cells, interfering in cellular processes, possibly through oxidative stress. |
| فهرسة مساهمة: |
Keywords: antitumoral potential; bladder cancer cells; cell cycle kinetics; cell migration; naphthoquinones |
| تواريخ الأحداث: |
Date Created: 20231221 Latest Revision: 20231221 |
| رمز التحديث: |
20231221 |
| DOI: |
10.1080/14786419.2023.2293156 |
| PMID: |
38126137 |
| قاعدة البيانات: |
MEDLINE |
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