Tumor Microenvironment-Specific Driven Nanoagents for Synergistic Mitochondria Damage-Related Immunogenic Cell Death and Alleviated Immunosuppression.

التفاصيل البيبلوغرافية
العنوان:	Tumor Microenvironment-Specific Driven Nanoagents for Synergistic Mitochondria Damage-Related Immunogenic Cell Death and Alleviated Immunosuppression.
المؤلفون:	Qian Y; Shenzhen Research Institute, Shandong University, Shenzhen, 518057, P. R. China.; Institute of Molecular Sciences and Engineering, Institute of Frontier and Interdisciplinary Science, Shandong University, Qingdao, 266237, P. R. China., Chen W; Institute of Molecular Sciences and Engineering, Institute of Frontier and Interdisciplinary Science, Shandong University, Qingdao, 266237, P. R. China., Wang M; Institute of Molecular Sciences and Engineering, Institute of Frontier and Interdisciplinary Science, Shandong University, Qingdao, 266237, P. R. China., Xie Y; Institute of Molecular Sciences and Engineering, Institute of Frontier and Interdisciplinary Science, Shandong University, Qingdao, 266237, P. R. China., Qiao L; Institute of Molecular Sciences and Engineering, Institute of Frontier and Interdisciplinary Science, Shandong University, Qingdao, 266237, P. R. China., Sun Q; Institute of Molecular Sciences and Engineering, Institute of Frontier and Interdisciplinary Science, Shandong University, Qingdao, 266237, P. R. China., Gao M; Institute of Molecular Sciences and Engineering, Institute of Frontier and Interdisciplinary Science, Shandong University, Qingdao, 266237, P. R. China., Li C; Shenzhen Research Institute, Shandong University, Shenzhen, 518057, P. R. China.; Institute of Molecular Sciences and Engineering, Institute of Frontier and Interdisciplinary Science, Shandong University, Qingdao, 266237, P. R. China.
المصدر:	Small methods [Small Methods] 2024 Jul; Vol. 8 (7), pp. e2301231. Date of Electronic Publication: 2023 Dec 21.
نوع المنشور:	Journal Article
اللغة:	English
بيانات الدورية:	Publisher: WILEY-VCH Verlag GmbH & Co. KGaA Country of Publication: Germany NLM ID: 101724536 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2366-9608 (Electronic) Linking ISSN: 23669608 NLM ISO Abbreviation: Small Methods Subsets: MEDLINE
أسماء مطبوعة:	Original Publication: Weinheim : WILEY-VCH Verlag GmbH & Co. KGaA, [2017]-
مواضيع طبية MeSH:	Tumor Microenvironment/drug effects , Mitochondria/drug effects , Immunogenic Cell Death/drug effects , Nanoparticles/chemistry, Animals ; Mice ; Humans ; Silicon Dioxide/chemistry ; Cell Line, Tumor ; Immunotherapy/methods ; Curcumin/pharmacology ; Curcumin/chemistry ; Curcumin/administration & dosage ; Immunosuppression Therapy ; Indoleamine-Pyrrole 2,3,-Dioxygenase/metabolism ; Oxidative Stress/drug effects ; Female ; Antineoplastic Agents/pharmacology ; Antineoplastic Agents/chemistry
مستخلص:	Despite significant breakthroughs in immunotherapy, the limitations of inadequate immune stimulation and stubborn immune resistance continue to present opportunities and challenges. Therefore, a two-pronged approach, encompassing the activation of immunogenic cell death (ICD) and blocking the indoleamine 2,3-dioxygenase (IDO)-mediated pathway, is devised to elicit systemic anti-tumor immunity and alleviate immunosuppression. Herein, a tumor microenvironment (TME)-specific driven nanoagent is composed of a tetrasulfide bond-bridged mesoporous silica layer (MON) coated up-conversion nanoparticles as a nano-carrier, combines Fe ²⁺ , curcumin, and indoximod for operating chemodynamic therapy/chemotherapy/immunotherapy. The consumption of glutathione (GSH) caused by MON degradation, the Fenton reaction of Fe ²⁺ , and curcumin triggering mitochondrial damage collectively exacerbate the oxidative stress, leading to a violent immunoreaction and reversal of the immunosuppressive TME through a combination of IDO-inhibitors. Meanwhile, upconversion luminescence (UCL) imaging serves as a significant guiding tool for drug delivery and the treatment of nanoagents. In vivo and in vitro experiment results demonstrate that the nanosystem not only effectively inhibits the growth of primary tumors but also induces immune priming and memory effects to reject re-challenged tumors. The strategy as a complementary approach displays great potential for future immunotherapy along with other multimodal treatment modes. (© 2023 Wiley‐VCH GmbH.)
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معلومات مُعتمدة:	52250077 National Natural Science Foundation of China; 52272156 National Natural Science Foundation of China; 52202175 National Natural Science Foundation of China; 22005325 National Natural Science Foundation of China; SDCX-ZG-202201008 Shandong Postdoctoral Innovation Project; 2022M721911 Postdoctoral Research Foundation of China; ZR2022QE044 Natural Science Foundation of Shandong Province; ZR2020ZD36 Natural Science Foundation of Shandong Province; ts20190911 Taishan Scholar Foundation of Shandong Province; 2022A1515010461 Basic and Applied Basic Research Foundation of Guangdong Province
فهرسة مساهمة:	Keywords: chemodynamic therapy; immunogenic cell death; indoleamine 2,3‐dioxygenase inhibitor; mitochondrial damage; oxidative stress
المشرفين على المادة:	7631-86-9 (Silicon Dioxide) IT942ZTH98 (Curcumin) 0 (Indoleamine-Pyrrole 2,3,-Dioxygenase) 0 (Antineoplastic Agents)
تواريخ الأحداث:	Date Created: 20231221 Date Completed: 20240720 Latest Revision: 20240720
رمز التحديث:	20240721
DOI:	10.1002/smtd.202301231
PMID:	38126694
قاعدة البيانات:	MEDLINE

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تدمد:	2366-9608
DOI:	10.1002/smtd.202301231