دورية أكاديمية
أعرض في EDS

Folate deficiency modifies the risk of CIN3+ associated with DNA methylation levels: a nested case-control study from the ASCUS-COL trial.

التفاصيل البيبلوغرافية
العنوان: Folate deficiency modifies the risk of CIN3+ associated with DNA methylation levels: a nested case-control study from the ASCUS-COL trial.
المؤلفون: Agudelo MC; Infection and Cancer Group, School of Medicine, Universidad de Antioquia, Carrera 51D No 62-29, 050010, Medellín, Colombia., Agudelo S; Infection and Cancer Group, School of Medicine, Universidad de Antioquia, Carrera 51D No 62-29, 050010, Medellín, Colombia., Lorincz A; Centre for Cancer Prevention, Wolfson Institute of Population Health, Queen Mary University of London, London, UK., Ramírez AT; Infection and Cancer Group, School of Medicine, Universidad de Antioquia, Carrera 51D No 62-29, 050010, Medellín, Colombia.; Postdoctoral Fellow at the Prevention and Implementation Group, International Agency for Research On Cancer/World Health Organization, Lyon, France., Castañeda KM; Infection and Cancer Group, School of Medicine, Universidad de Antioquia, Carrera 51D No 62-29, 050010, Medellín, Colombia., Garcés-Palacio I; Epidemiology Group, School of Public Health, Universidad de Antioquia, Medellín, Colombia., Zea AH; Stanley S. Scott Cancer Center, Microbiology, Immunology and Parasitology, LSU Health Sciences Center, New Orleans, USA., Piyathilake C; Department of Nutrition Sciences, The University of Alabama at Birmingham, Birmingham, USA., Sanchez GI; Infection and Cancer Group, School of Medicine, Universidad de Antioquia, Carrera 51D No 62-29, 050010, Medellín, Colombia. gloria.sanchez@udea.edu.co.
المصدر: European journal of nutrition [Eur J Nutr] 2024 Mar; Vol. 63 (2), pp. 563-572. Date of Electronic Publication: 2023 Dec 21.
نوع المنشور: Randomized Controlled Trial; Journal Article
اللغة: English
بيانات الدورية: Publisher: Steinkopff Country of Publication: Germany NLM ID: 100888704 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1436-6215 (Electronic) Linking ISSN: 14366207 NLM ISO Abbreviation: Eur J Nutr Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Darmstadt, Germany : Steinkopff, 1999-
مواضيع طبية MeSH: Atypical Squamous Cells of the Cervix* , Folic Acid Deficiency*/genetics , Uterine Cervical Dysplasia*/diagnosis , Uterine Cervical Dysplasia*/genetics , Uterine Cervical Dysplasia*/pathology, Female ; Humans ; Case-Control Studies ; DNA Methylation ; Folic Acid
مستخلص: Purpose: To our knowledge, there are very few studies evaluating if the levels of folate modify the risk of cervical intraepithelial neoplasia grade 2 and higher (CIN2+ and CIN3+) associated with the levels of HPV genome methylation, two cofactors related to single carbon metabolism and independently associated with cervical cancer in previous studies. We conducted a case-control study nested in a three-arm randomized clinical pragmatic trial (ASCUS-COL trial) to evaluate the risk of CIN3+ associated with methylation levels according to serum folate concentrations.
Methods: Cases (n = 155) were women with histologically confirmed CIN2+ (113 CIN2, 38 CIN3, and 4 SCC) and controls were age and follow-up time at diagnosis-matched women with histologically confirmed ≤ CIN1 (n = 155), selected from the 1122 hrHPV + women of this trial. The concentrations of serum folate were determined by the radioimmunoassay SimulTRAC-SNB-VitaminB12/Folate-RIAKit and the methylation levels by the S5 classifier. Stepwise logistic regression models were used to estimate the association between folate or methylation levels and CIN2+ or CIN3+. The joint effect of folate levels and methylation on the risk of CIN3+ was estimated using combinations of categorical stratifications.
Results: Folate levels were significantly lower in women with CIN3+ than in other diagnostic groups (p = 0.019). The risk of CIN3+ was eight times higher (OR 8.9, 95% CI 3.4-24.9) in women with folate deficiency and high methylation levels than in women with normal folate and high methylation levels (OR 1.4, 95% CI 0.4-4.6).
Conclusion: High methylation and deficient folate independently increased the risk of CIN3+ while deficient folate combined with high methylation was associated with a substantially elevated risk of CIN3+.
(© 2023. The Author(s).)
References: Papillomavirus Res. 2019 Jun;7:180-183. (PMID: 30978415)
Cell Rep. 2018 Oct 23;25(4):1066-1080.e8. (PMID: 30355485)
Int J Cancer. 2020 Oct 2;:. (PMID: 33006400)
Mol Cancer Res. 2008 Aug;6(8):1365-74. (PMID: 18667590)
Nat Rev Cancer. 2014 Jun;14(6):395-405. (PMID: 24854082)
Nutrition. 2007 Mar;23(3):203-10. (PMID: 17276035)
J Biopharm Stat. 1999 May;9(2):241-51. (PMID: 10379691)
Cancer Epidemiol Biomarkers Prev. 2009 Oct;18(10):2782-9. (PMID: 19755648)
Br J Cancer. 2007 Nov 19;97(10):1457-64. (PMID: 17971771)
BMC Cancer. 2022 Jun 2;22(1):605. (PMID: 35655145)
Am J Clin Nutr. 2011 Jul;94(1):303S-312S. (PMID: 21593502)
Cancer Causes Control. 2011 Jan;22(1):63-72. (PMID: 21052817)
Nutrients. 2019 Mar 13;11(3):. (PMID: 30871166)
Vaccine. 2006 Aug 31;24 Suppl 3:S3/1-10. (PMID: 16949995)
J Nutr. 2003 Oct;133(10):3166-9. (PMID: 14519804)
Cancer Epidemiol Biomarkers Prev. 2002 Apr;11(4):353-9. (PMID: 11927495)
J Natl Cancer Inst. 2012 Apr 4;104(7):556-65. (PMID: 22448030)
Am J Clin Nutr. 1994 Oct;60(4):559-66. (PMID: 8092091)
Gynecol Oncol. 2014 Mar;132(3):709-14. (PMID: 24508839)
Am J Clin Nutr. 2011 Oct;94(4):1053-62. (PMID: 21813806)
Expert Rev Mol Diagn. 2014 Apr;14(3):293-305. (PMID: 24649818)
Int J Cancer. 2022 Oct 1;151(7):993-1004. (PMID: 35477862)
Food Nutr Bull. 2008 Jun;29(2 Suppl):S238-44. (PMID: 18709899)
Am J Clin Nutr. 2009 Feb;89(2):702S-6S. (PMID: 19141696)
Am J Clin Pathol. 2007 May;127(5):805-15. (PMID: 17439841)
Int J Cancer. 2005 Nov 20;117(4):629-37. (PMID: 15912536)
Salud Publica Mex. 2003;45 Suppl 4:S508-19. (PMID: 14746045)
Int J Cancer. 2021 Mar 15;148(6):1383-1393. (PMID: 33006394)
Proc Am Thorac Soc. 2007 May;4(2):176-8, discussion 178-9. (PMID: 17494727)
Int J Cancer. 2014 Sep 15;135(6):1425-32. (PMID: 24535756)
Int J Womens Health. 2010 Aug 09;2:7-12. (PMID: 21072292)
JAMA. 2001 Mar 21;285(11):1500-5. (PMID: 11255427)
Cancer Epidemiol Biomarkers Prev. 1993 Sep-Oct;2(5):423-31. (PMID: 8220086)
Int J Cancer. 2016 Jun 1;138(11):2745-51. (PMID: 26790008)
Cancer Prev Res (Phila). 2009 Jul;2(7):658-64. (PMID: 19542191)
J Clin Microbiol. 2000 Jan;38(1):357-61. (PMID: 10618116)
Nat Rev Cancer. 2002 May;2(5):342-50. (PMID: 12044010)
J Nutr. 1999 Apr;129(4):779-82. (PMID: 10203550)
J Pathol. 1999 Sep;189(1):12-9. (PMID: 10451482)
J Nutr. 2000 Feb;130(2):129-32. (PMID: 10720158)
Carcinogenesis. 2007 Dec;28(12):2434-42. (PMID: 17893234)
Cancer Res. 2004 Dec 1;64(23):8788-93. (PMID: 15574793)
Cancer Prev Res (Phila). 2014 Nov;7(11):1128-37. (PMID: 25145486)
Int J Cancer. 2010 Feb 1;126(3):703-14. (PMID: 19642096)
معلومات مُعتمدة: 001 International WHO_ World Health Organization
فهرسة مساهمة: Keywords: Cervical cancer; DNA methylation; Folate; HPV
المشرفين على المادة: 935E97BOY8 (Folic Acid)
تواريخ الأحداث: Date Created: 20231221 Date Completed: 20240228 Latest Revision: 20240808
رمز التحديث: 20240808
مُعرف محوري في PubMed: PMC10899296
DOI: 10.1007/s00394-023-03289-4
PMID: 38129362
قاعدة البيانات: MEDLINE
الوصف
تدمد:1436-6215
DOI:10.1007/s00394-023-03289-4