دورية أكاديمية
Folate deficiency modifies the risk of CIN3+ associated with DNA methylation levels: a nested case-control study from the ASCUS-COL trial.
العنوان: | Folate deficiency modifies the risk of CIN3+ associated with DNA methylation levels: a nested case-control study from the ASCUS-COL trial. |
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المؤلفون: | Agudelo MC; Infection and Cancer Group, School of Medicine, Universidad de Antioquia, Carrera 51D No 62-29, 050010, Medellín, Colombia., Agudelo S; Infection and Cancer Group, School of Medicine, Universidad de Antioquia, Carrera 51D No 62-29, 050010, Medellín, Colombia., Lorincz A; Centre for Cancer Prevention, Wolfson Institute of Population Health, Queen Mary University of London, London, UK., Ramírez AT; Infection and Cancer Group, School of Medicine, Universidad de Antioquia, Carrera 51D No 62-29, 050010, Medellín, Colombia.; Postdoctoral Fellow at the Prevention and Implementation Group, International Agency for Research On Cancer/World Health Organization, Lyon, France., Castañeda KM; Infection and Cancer Group, School of Medicine, Universidad de Antioquia, Carrera 51D No 62-29, 050010, Medellín, Colombia., Garcés-Palacio I; Epidemiology Group, School of Public Health, Universidad de Antioquia, Medellín, Colombia., Zea AH; Stanley S. Scott Cancer Center, Microbiology, Immunology and Parasitology, LSU Health Sciences Center, New Orleans, USA., Piyathilake C; Department of Nutrition Sciences, The University of Alabama at Birmingham, Birmingham, USA., Sanchez GI; Infection and Cancer Group, School of Medicine, Universidad de Antioquia, Carrera 51D No 62-29, 050010, Medellín, Colombia. gloria.sanchez@udea.edu.co. |
المصدر: | European journal of nutrition [Eur J Nutr] 2024 Mar; Vol. 63 (2), pp. 563-572. Date of Electronic Publication: 2023 Dec 21. |
نوع المنشور: | Randomized Controlled Trial; Journal Article |
اللغة: | English |
بيانات الدورية: | Publisher: Steinkopff Country of Publication: Germany NLM ID: 100888704 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1436-6215 (Electronic) Linking ISSN: 14366207 NLM ISO Abbreviation: Eur J Nutr Subsets: MEDLINE |
أسماء مطبوعة: | Original Publication: Darmstadt, Germany : Steinkopff, 1999- |
مواضيع طبية MeSH: | Atypical Squamous Cells of the Cervix* , Folic Acid Deficiency*/genetics , Uterine Cervical Dysplasia*/diagnosis , Uterine Cervical Dysplasia*/genetics , Uterine Cervical Dysplasia*/pathology, Female ; Humans ; Case-Control Studies ; DNA Methylation ; Folic Acid |
مستخلص: | Purpose: To our knowledge, there are very few studies evaluating if the levels of folate modify the risk of cervical intraepithelial neoplasia grade 2 and higher (CIN2+ and CIN3+) associated with the levels of HPV genome methylation, two cofactors related to single carbon metabolism and independently associated with cervical cancer in previous studies. We conducted a case-control study nested in a three-arm randomized clinical pragmatic trial (ASCUS-COL trial) to evaluate the risk of CIN3+ associated with methylation levels according to serum folate concentrations. Methods: Cases (n = 155) were women with histologically confirmed CIN2+ (113 CIN2, 38 CIN3, and 4 SCC) and controls were age and follow-up time at diagnosis-matched women with histologically confirmed ≤ CIN1 (n = 155), selected from the 1122 hrHPV + women of this trial. The concentrations of serum folate were determined by the radioimmunoassay SimulTRAC-SNB-VitaminB12/Folate-RIAKit and the methylation levels by the S5 classifier. Stepwise logistic regression models were used to estimate the association between folate or methylation levels and CIN2+ or CIN3+. The joint effect of folate levels and methylation on the risk of CIN3+ was estimated using combinations of categorical stratifications. Results: Folate levels were significantly lower in women with CIN3+ than in other diagnostic groups (p = 0.019). The risk of CIN3+ was eight times higher (OR 8.9, 95% CI 3.4-24.9) in women with folate deficiency and high methylation levels than in women with normal folate and high methylation levels (OR 1.4, 95% CI 0.4-4.6). Conclusion: High methylation and deficient folate independently increased the risk of CIN3+ while deficient folate combined with high methylation was associated with a substantially elevated risk of CIN3+. (© 2023. The Author(s).) |
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معلومات مُعتمدة: | 001 International WHO_ World Health Organization |
فهرسة مساهمة: | Keywords: Cervical cancer; DNA methylation; Folate; HPV |
المشرفين على المادة: | 935E97BOY8 (Folic Acid) |
تواريخ الأحداث: | Date Created: 20231221 Date Completed: 20240228 Latest Revision: 20240808 |
رمز التحديث: | 20240808 |
مُعرف محوري في PubMed: | PMC10899296 |
DOI: | 10.1007/s00394-023-03289-4 |
PMID: | 38129362 |
قاعدة البيانات: | MEDLINE |
تدمد: | 1436-6215 |
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DOI: | 10.1007/s00394-023-03289-4 |