دورية أكاديمية
Features of infective endocarditis in a contemporary cohort of persons who inject drugs: a matched comparison analysis of long-term prognostic factors.
| العنوان: | Features of infective endocarditis in a contemporary cohort of persons who inject drugs: a matched comparison analysis of long-term prognostic factors. |
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| المؤلفون: | Ramadan MS; Department of Precision Medicine, University of Campania 'Luigi Vanvitelli', Via de Crecchio, 7, 80138, Naples, Italy.; Division of Infectious Diseases, Duke University Medical School, Durham, NC, USA., Bertolino L; Department of Precision Medicine, University of Campania 'Luigi Vanvitelli', Via de Crecchio, 7, 80138, Naples, Italy., Boccia F; Unit of Infectious & Transplant Medicine, A.O.R.N. Ospedali dei Colli - Ospedale Monaldi, Piazzale Ettore Ruggieri, 80131, Naples, Italy.; Department of Advanced Medical and Surgical Sciences, University of Campania 'Luigi Vanvitelli', Piazza Luigi Miraglia, 2 80138, Naples, Italy., Hamieh M; Department of Precision Medicine, University of Campania 'Luigi Vanvitelli', Via de Crecchio, 7, 80138, Naples, Italy., Peluso AM; Department of Precision Medicine, University of Campania 'Luigi Vanvitelli', Via de Crecchio, 7, 80138, Naples, Italy., Gallo R; Department of Precision Medicine, University of Campania 'Luigi Vanvitelli', Via de Crecchio, 7, 80138, Naples, Italy., Patauner F; Department of Precision Medicine, University of Campania 'Luigi Vanvitelli', Via de Crecchio, 7, 80138, Naples, Italy., De Santo LS; Department of Translational Medical Sciences and Unit of Cardiac Surgery, University of Campania 'Luigi Vanvitelli', A.O.R.N. Ospedali dei Colli - Ospedale Monaldi, Piazzale Ettore Ruggieri, 80131, Naples, Italy., Carozza A; Department of Translational Medical Sciences and Unit of Cardiac Surgery, University of Campania 'Luigi Vanvitelli', A.O.R.N. Ospedali dei Colli - Ospedale Monaldi, Piazzale Ettore Ruggieri, 80131, Naples, Italy., Zampino R; Unit of Infectious & Transplant Medicine, A.O.R.N. Ospedali dei Colli - Ospedale Monaldi, Piazzale Ettore Ruggieri, 80131, Naples, Italy.; Department of Advanced Medical and Surgical Sciences, University of Campania 'Luigi Vanvitelli', Piazza Luigi Miraglia, 2 80138, Naples, Italy., Durante-Mangoni E; Department of Precision Medicine, University of Campania 'Luigi Vanvitelli', Via de Crecchio, 7, 80138, Naples, Italy. emanuele.durante@unicampania.it.; Unit of Infectious & Transplant Medicine, A.O.R.N. Ospedali dei Colli - Ospedale Monaldi, Piazzale Ettore Ruggieri, 80131, Naples, Italy. emanuele.durante@unicampania.it. |
| مؤلفون مشاركون: | Monaldi Hospital Cardiovascular Infection Study Group |
| المصدر: | Internal and emergency medicine [Intern Emerg Med] 2024 Mar; Vol. 19 (2), pp. 455-464. Date of Electronic Publication: 2023 Dec 21. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Springer Country of Publication: Italy NLM ID: 101263418 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1970-9366 (Electronic) Linking ISSN: 18280447 NLM ISO Abbreviation: Intern Emerg Med Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Milan : Springer Original Publication: Rome, Italy : CEPI-AIM Group, 2006- |
| مواضيع طبية MeSH: | Drug Users* , Substance Abuse, Intravenous*/complications , Substance Abuse, Intravenous*/epidemiology , Diabetes Mellitus, Type 2*/complications , Endocarditis*/etiology , Endocarditis*/complications , Hepatitis C*/complications , Endocarditis, Bacterial*/etiology , Endocarditis, Bacterial*/complications, Humans ; Staphylococcus aureus ; Prognosis ; Retrospective Studies |
| مستخلص: | The objective of the study was to assess the short- and long-term mortality of infective endocarditis (IE) among people who inject drugs (PWID). Using prospectively collected data on hospitalized patients (years 2000 through 2021) with IE, PWID were identified and included in this study. Survival analysis was performed to analyze short- and long-term mortality and study their risk factors among PWID and a matched group of non-intravenous drug users (N-IDU). In a study of 485 patients admitted for IE, 55 (11%) of them were PWID. These PWID patients were 1:1 age- and sex- matched to an N-IDU group (N = 55 per group). Both groups had similar baseline comorbid conditions, including congestive heart failure, type 2 diabetes, and neoplastic diseases. However, PWID were more likely to have HCV co-infection (62% vs 16%, respectively, p < 0.001) and advanced liver disease/cirrhosis (52% vs 7.9%, respectively, p < 0.001). IE in PWID more often affected the tricuspid valve (42% vs 22%, respectively, p = 0.024) and presented with more embolic events (66% vs 35%, respectively, p < 0.01). S. aureus was the primary cause of IE in PWID (44% vs 21%, respectively, p = 0.01). After adjusting for other variables, PWID (HR = 2.99, 95% CI [1.06, 8.43], p = 0.038) and valve bioprosthetic replacement (HR = 5.37, 95% CI [1.3, 22.1], p = 0.02) were independently associated with increased mortality risk, whereas IE caused by tricuspid valve infection was associated with reduced mortality risk (HR = 0.25, 95% CI [0.06, 0.97], p = 0.046). In this cohort, PWID had increased risk of long-term mortality after hospital discharge for IE, when compared to matched N-IDU with similar baseline characteristics. The reasons behind the significant increase in mortality warrant further investigation. (© 2023. The Author(s), under exclusive licence to Società Italiana di Medicina Interna (SIMI).) |
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| فهرسة مساهمة: | Keywords: Embolism; Liver disease; Mortality; Opioid use disorder; Valvular heart disease |
| تواريخ الأحداث: | Date Created: 20231221 Date Completed: 20240321 Latest Revision: 20240321 |
| رمز التحديث: | 20240321 |
| DOI: | 10.1007/s11739-023-03502-6 |
| PMID: | 38129537 |
| قاعدة البيانات: | MEDLINE |
Find this article in full text from Springer Verlag. 
Full Text Finder | تدمد: | 1970-9366 |
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| DOI: | 10.1007/s11739-023-03502-6 |