دورية أكاديمية
أعرض في EDS

Modeling clothing as a secondary source of exposure to SVOCs across indoor microenvironments.

التفاصيل البيبلوغرافية
العنوان: Modeling clothing as a secondary source of exposure to SVOCs across indoor microenvironments.
المؤلفون: Kvasnicka J; Department of Earth Sciences, University of Toronto, Toronto, Ontario, M5S 3B1, Canada., Cohen Hubal EA; Center for Public Health and Environmental Assessment, U.S. Environmental Protection Agency, Durham, NC, 27711, USA., Diamond ML; Department of Earth Sciences, University of Toronto, Toronto, Ontario, M5S 3B1, Canada. miriam.diamond@utoronto.ca.; School of the Environment, University of Toronto, Toronto, Ontario, M5S 3E8, Canada. miriam.diamond@utoronto.ca.
المصدر: Journal of exposure science & environmental epidemiology [J Expo Sci Environ Epidemiol] 2024 Mar; Vol. 34 (2), pp. 376-385. Date of Electronic Publication: 2023 Dec 21.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Nature Pub. Group Country of Publication: United States NLM ID: 101262796 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1559-064X (Electronic) Linking ISSN: 15590631 NLM ISO Abbreviation: J Expo Sci Environ Epidemiol Subsets: MEDLINE
أسماء مطبوعة: Original Publication: New York, NY : Nature Pub. Group, c2006-
مواضيع طبية MeSH: Air Pollution, Indoor*/analysis , Clothing* , Volatile Organic Compounds*/analysis, Humans ; Phthalic Acids ; Computer Simulation ; Inhalation Exposure/analysis ; Environmental Exposure/analysis ; Air Pollutants/analysis ; Models, Theoretical
مستخلص: Background: Evidence suggests that clothing can influence human exposure to semi-volatile organic compounds (SVOCs) through transdermal uptake and inhalation.
Objectives: The objectives of this study were [1] to investigate the potential for clothing to function as a transport vector and secondary source of gas-phase SVOCs across indoor microenvironments, [2] to elucidate how clothing storage, wear, and laundering can influence the dynamics of transdermal uptake, and [3] to assess the potential for multiple human occupants to influence the multimedia dynamics of SVOCs indoors.
Methods: A computational modeling framework (ABICAM) was expanded, applied, and evaluated by simulating and augmenting two "real-world" chamber experiments. A primary strength of this framework was its representation of occupants and their clothing as unique entities with the potential for location changes.
Results: Estimates of transdermal uptake of diethyl phthalate (DEP) and di(n-butyl) phthalate (DnBP) were generally consistent with those extrapolated from measured concentrations of urinary metabolites, and those predicted by two other mechanistic models. ABICAM predicted that clean clothing (long sleeves, long pants, and socks, 100% cotton, 1 mm thick) readily accumulated DEP (6900-9700 μg) and DnBP (4500-4800 μg) from the surrounding chamber air over 6 h of exposure to average concentrations of 233 (DEP) and 114 (DnBP) μg·m -3 . Because of their high capacity, clean clothing also effectively minimized transdermal uptake. In addition, ABICAM predicted that contaminated clothing functioned as a vector for transporting DEP and DnBP across indoor microenvironments and reemitted 13-80% (DEP) and 3-27% (DnBP) of the accumulated masses over 48 h.
Significance: Though the estimated secondary inhalation exposures from contaminated clothing were low compared to the corresponding primary exposures, these secondary exposures could be accentuated in other contexts, for example, involving longer timeframes of clothing storage, multiple occupants wearing contaminated clothing, and/or repeated instances of clothing-mediated transport of contaminants (e.g., from an occupational setting).
Impact: This modeling study reaffirms the effectiveness of clean clothing in reducing transdermal uptake of airborne SVOCs and conversely, that contaminated clothing could be a source of SVOC exposure via transdermal uptake and by acting as a vector for transporting those contaminants to other locations.
(© 2023. The Author(s), under exclusive licence to Springer Nature America, Inc.)
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معلومات مُعتمدة: EPA999999 United States ImEPA Intramural EPA
المشرفين على المادة: 0 (Volatile Organic Compounds)
0 (Phthalic Acids)
UF064M00AF (diethyl phthalate)
0 (Air Pollutants)
تواريخ الأحداث: Date Created: 20231222 Date Completed: 20240531 Latest Revision: 20240603
رمز التحديث: 20240603
مُعرف محوري في PubMed: PMC11144090
DOI: 10.1038/s41370-023-00621-2
PMID: 38129669
قاعدة البيانات: MEDLINE
الوصف
تدمد:1559-064X
DOI:10.1038/s41370-023-00621-2