دورية أكاديمية
أعرض في EDS

Poisoning by Baccharis coridifolia in Early-Weaned Beef Calves: Pathological Study and New Macrocyclic Trichothecene Identification.

التفاصيل البيبلوغرافية
العنوان: Poisoning by Baccharis coridifolia in Early-Weaned Beef Calves: Pathological Study and New Macrocyclic Trichothecene Identification.
المؤلفون: Machado M; Plataforma de Investigación en Salud Animal (PSA), Instituto Nacional de Investigación Agropecuaria (INIA), Estación Experimental Tacuarembó, Tacuarembó 45000, Uruguay., Martínez R; Independent Researcher, Tacuarembó 45000, Uruguay., Andres S; CENUR Noreste, Universidad de la República, Tacuarembó 45000, Uruguay., Sumarah MW; London Research and Development Centre, Agriculture & Agri-Food Canada, London, ON N5V 4T3, Canada., Renaud JB; London Research and Development Centre, Agriculture & Agri-Food Canada, London, ON N5V 4T3, Canada., Armién AG; California Animal Health & Food Safety Laboratory System (CAHFS), School of Veterinary Medicine, University of California, Davis, CA 95616, USA., Barros CSL; Faculdade de Medicina Veterinária e Zootecnia (FMZV), Universidade Federal de Mato Grosso do Sul (UFMS), Campo Grande 79070-900, Mato Grosso do Sul, Brazil., Riet-Correa F; Programa de Pós-Graduação em Ciência Animal nos Trópicos, Universidade Federal da Bahia (UFBA), Salvador 49170-110, Bahia, Brazil., Menchaca A; Plataforma de Investigación en Salud Animal (PSA), Instituto Nacional de Investigación Agropecuaria (INIA), Estación Experimental Tacuarembó, Tacuarembó 45000, Uruguay., Schild CO; Plataforma de Investigación en Salud Animal (PSA), Instituto Nacional de Investigación Agropecuaria (INIA), Estación Experimental Tacuarembó, Tacuarembó 45000, Uruguay.; California Animal Health and Food Safety Laboratory System-San Bernardino Branch, University of California, San Bernardino, CA 92408, USA.
المصدر: Toxins [Toxins (Basel)] 2023 Dec 01; Vol. 15 (12). Date of Electronic Publication: 2023 Dec 01.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101530765 Publication Model: Electronic Cited Medium: Internet ISSN: 2072-6651 (Electronic) Linking ISSN: 20726651 NLM ISO Abbreviation: Toxins (Basel) Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Basel : MDPI
مواضيع طبية MeSH: Baccharis* , Trichothecenes*/toxicity, Cattle ; Animals ; Diarrhea ; Cell Death
مستخلص: This study investigated two outbreaks of spontaneous poisoning by Baccharis coridifolia (Asteraceae) in early-weaned beef calves in Tacuarembó, Uruguay. A total of 34 affected calves showed signs of salivation, anorexia, apathy, marked dehydration, and diarrhea. Deaths occurred 36-72 h after consumption and mortality varied from 37.5% to 43.3% for outbreak 1 and outbreak 2, respectively. The main pathological findings include diffuse severe necrosis of the prestomachs and lymphoid tissues. Ultrastructurally, epithelial cells of the rumen showed swelling, lysis of the organelles, degradation of intercellular attachments, and degradation of the nuclear chromatin. Using LC-MS with diagnostic fragmentation filtering, 56 macrocyclic trichothecenes including glycosyl and malonyl conjugates were identified. The total concentration of macrocyclic trichothecenes, including conjugates, was estimated to be 1.2 ± 0.1 mg/g plant material. This is the first report of these malonyl-glucose conjugates from Baccharis coridifolia .
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فهرسة مساهمة: Keywords: Baccharis; Uruguay; mio-mio; poisonous plants; ruminants; toxicity
المشرفين على المادة: 7OO57LYZ5I (trichothecene)
0 (Trichothecenes)
تواريخ الأحداث: Date Created: 20231222 Date Completed: 20231225 Latest Revision: 20240227
رمز التحديث: 20240227
مُعرف محوري في PubMed: PMC10747622
DOI: 10.3390/toxins15120681
PMID: 38133185
قاعدة البيانات: MEDLINE
الوصف
تدمد:2072-6651
DOI:10.3390/toxins15120681