دورية أكاديمية
أعرض في EDS

Multidrug-Resistant Staphylococcus aureus Strains Thrive in Dairy and Beef Production, Processing, and Supply Lines in Five Geographical Areas in Ethiopia.

التفاصيل البيبلوغرافية
العنوان: Multidrug-Resistant Staphylococcus aureus Strains Thrive in Dairy and Beef Production, Processing, and Supply Lines in Five Geographical Areas in Ethiopia.
المؤلفون: Gizaw F; School of Veterinary Science, Arsi University, Assella P.O. Box 193, Ethiopia., Kekeba T; College of Veterinary Medicine and Agriculture, Addis Ababa University, Bishoftu P.O. Box 34, Ethiopia., Teshome F; College of Veterinary Medicine and Agriculture, Addis Ababa University, Bishoftu P.O. Box 34, Ethiopia., Kebede M; College of Veterinary Medicine and Agriculture, Addis Ababa University, Bishoftu P.O. Box 34, Ethiopia., Abreham T; College of Veterinary Medicine and Agriculture, Addis Ababa University, Bishoftu P.O. Box 34, Ethiopia., Berhe HH; College of Veterinary Medicine and Agriculture, Addis Ababa University, Bishoftu P.O. Box 34, Ethiopia., Ayana D; College of Veterinary Medicine and Agriculture, Addis Ababa University, Bishoftu P.O. Box 34, Ethiopia., Edao BM; College of Veterinary Medicine and Agriculture, Addis Ababa University, Bishoftu P.O. Box 34, Ethiopia., Waktole H; College of Veterinary Medicine and Agriculture, Addis Ababa University, Bishoftu P.O. Box 34, Ethiopia., Tufa TB; College of Veterinary Medicine and Agriculture, Addis Ababa University, Bishoftu P.O. Box 34, Ethiopia., Abunna F; College of Veterinary Medicine and Agriculture, Addis Ababa University, Bishoftu P.O. Box 34, Ethiopia., Beyi AF; Department of Veterinary Microbiology and Preventive Medicine, College of Veterinary Medicine, Iowa State University, Ames, IA 50011, USA., Abdi RD; Department of Biomedical Sciences, College of Veterinary Medicine, Long Island University, Greenvale, NY 11548, USA.
المصدر: Veterinary sciences [Vet Sci] 2023 Nov 22; Vol. 10 (12). Date of Electronic Publication: 2023 Nov 22.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101680127 Publication Model: Electronic Cited Medium: Internet ISSN: 2306-7381 (Electronic) Linking ISSN: 23067381 NLM ISO Abbreviation: Vet Sci Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: Basel : MDPI, [2014]-
مستخلص: Livestock, farms, abattoirs, and food supply systems can become the source of foodborne pathogens, including S. aureus , in the absence of monitoring, general hygienic practices, and control. Studies are scarce on reservoirs (hiding places) and routes of entry of S. aureus into the food supply chain in Ethiopia. To fill these gaps, we evaluated the role of cows (milk), meat, equipment, and food handlers on the abundance and AMR of S. aureus in five geographical areas in central Oromia, Ethiopia. We isolated S. aureus from 10 different ecologies per area in 5 areas and tested their sensitivity to 14 antimicrobials of 9 different classes. We ranked the 5 areas and 10 ecologies by computing their multiple AMR index (MARI) at a cut-off value of 0.2 to determine 'high-risk' ecologies for AMR. We recorded as MDR if an isolate had resistance to ≥3 antimicrobial classes. We used a circos diagram to analyze if isolates with identical AMR patterns were shared between different ecologies. S. aureus is prevalent in central Oromia (16.1-18.3%), higher in dairy farms than in abattoirs, and varied among 10 ecologies ( p < 0.001) but not among 5 areas ( p > 0.05). Of the 92 isolates, 94.6% were penicillin-resistant. Their AMR prevalence was above 40% for 9 of 14 antimicrobials. All isolates (100%) had AMR in at least one antimicrobial class (range = 1-9; median = 5), indicating MDR was prevalent. The prevalence of MDR S. aureus varied ( p < 0.05) among areas and 10 ecologies; the highest was in slaughter lines. All isolates had a MARI of >0.2, indicating drug overuse, and S. aureus's AMR burden is high in central Oromia. Dairy farms had higher MARI values (0.44) than abattoirs (0.39). Of 10 ecologies, the highest and lowest MARI values were in the beef supply chain, i.e., slaughter line (0.67) and butcher's hand (0.25). Of the 68 different AMR patterns by 92 isolates against 14 antimicrobials, 53 patterns (77.9%) were unique to individual isolates, indicating they were phenotypically dissimilar. MDR S. aureus was widespread in central Oromia in dairy and meat supply chains, contaminating milk, meat, equipment, and workers in farm and abattoir settings. In the absence of strict regulations and interventions, MDR S. aureus can be disseminated from these epicenters to the public.
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معلومات مُعتمدة: RD/LT/194/2013 Addis Ababa University
فهرسة مساهمة: Keywords: S. aureus; antimicrobial resistance; ecology; epidemiology; food safety
تواريخ الأحداث: Date Created: 20231222 Latest Revision: 20231225
رمز التحديث: 20231225
مُعرف محوري في PubMed: PMC10747641
DOI: 10.3390/vetsci10120663
PMID: 38133214
قاعدة البيانات: MEDLINE
الوصف
تدمد:2306-7381
DOI:10.3390/vetsci10120663