دورية أكاديمية
Antifungal Activity of Chitosan Polymeric Nanoparticles and Correlation with Their pH Against Mucor circinelloides Causing Mucormycosis, Along with Penicillium notatum and Aspergillus Species.
| العنوان: | Antifungal Activity of Chitosan Polymeric Nanoparticles and Correlation with Their pH Against Mucor circinelloides Causing Mucormycosis, Along with Penicillium notatum and Aspergillus Species. |
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| المؤلفون: | Abo El-Ela FI; Department of Pharmacology, Faculty of Veterinary Medicine, Beni-Suef University, Beni-Suef, 62511, Egypt. fatma.aboel3la@vet.bsu.edu.eg., Hassan WH; Department of Microbiology, Mycology and Immunology, Faculty of Veterinary Medicine, Beni-Suef University, Beni-Suef, 62511, Egypt., Amer AM; Materials Science and Nanotechnology Department, Faculty of Postgraduate Studies for Advanced Sciences, Beni-Suef University, Beni-Suef, 62511, Egypt., El-Dek SI; Materials Science and Nanotechnology Department, Faculty of Postgraduate Studies for Advanced Sciences, Beni-Suef University, Beni-Suef, 62511, Egypt. |
| المصدر: | Current microbiology [Curr Microbiol] 2023 Dec 22; Vol. 81 (1), pp. 47. Date of Electronic Publication: 2023 Dec 22. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Springer International Country of Publication: United States NLM ID: 7808448 Publication Model: Electronic Cited Medium: Internet ISSN: 1432-0991 (Electronic) Linking ISSN: 03438651 NLM ISO Abbreviation: Curr Microbiol Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: New York, Springer International. |
| مواضيع طبية MeSH: | Mucormycosis*/drug therapy , Mucormycosis*/microbiology , Penicillium chrysogenum* , Chitosan*/pharmacology , Nanoparticles*, Humans ; Antifungal Agents/pharmacology ; Mucor ; Aspergillus niger ; Microbial Sensitivity Tests ; Hydrogen-Ion Concentration |
| مستخلص: | Mucormycosis is uncommon, yet it is more prevalent among individuals with underlying health conditions and those who are immunocompromised. Chitosan is studied because of its appealing properties and diverse applications. The purpose of this work is to synthesize chitosan nanoparticles (CSNPs) by ionic gelation method at various pH levels and test them against Mucor and other filamentous fungus. Field Emission Scanning Electron Microscope, Zeta sizer, Zeta potential, and Fourier Transformed Infrared Spectroscopy were used to characterize CSNPs. Hydrodynamic size increased considerably with increasing pH. Our CSNPs were tested against fungal isolates of Aspergillus Flavus RCMB 02783, Aspergillus Fumigatus RCMB 02564, and Aspergillus Niger RCMB 02588, Penicillium Notatum (NCPF 2881) and (M. circinelloides CNRMA 03.894) causing mucromycosis. Antifungal activity was investigated using Minimum inhibitory concentration (MIC), Minimum Fungicidal concentration (MFC), Disc diffusion assay, and Antifungal inhibitory percentages methods. The best antifungal efficacy results were obtained through CSNPs prepared at pH = 4.4 at very low concentration for MIC (1.03 or 2.75 μg/mL) with 100% M. circinelloides inhibition followed by pH = 4.6 with MIC (73 or 208 μg/mL) and 93% M. cirecinelloides inhibition %. Future usage of these materials in masks or wound dressing to avoid fungal infections, including mucormycosis following COVID-19, penicillium, and aspergillosis toxicity and infections. (© 2023. The Author(s).) |
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| المشرفين على المادة: | 0 (Antifungal Agents) 9012-76-4 (Chitosan) |
| SCR Organism: | Mucor circinelloides |
| تواريخ الأحداث: | Date Created: 20231222 Date Completed: 20231225 Latest Revision: 20240112 |
| رمز التحديث: | 20240112 |
| مُعرف محوري في PubMed: | PMC10746780 |
| DOI: | 10.1007/s00284-023-03555-y |
| PMID: | 38135799 |
| قاعدة البيانات: | MEDLINE |
Find this article in full text from Springer Verlag. 
Full Text Finder | تدمد: | 1432-0991 |
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| DOI: | 10.1007/s00284-023-03555-y |