دورية أكاديمية
أعرض في EDS

Tranexamic Acid in Hip Reconstructions in Children with Cerebral Palsy: A Double-Blind Randomized Controlled Clinical Trial.

التفاصيل البيبلوغرافية
العنوان: Tranexamic Acid in Hip Reconstructions in Children with Cerebral Palsy: A Double-Blind Randomized Controlled Clinical Trial.
المؤلفون: Zuccon A; Disabled Children's Care Association of São Paulo (AACD-SP), São Paulo 04027-000, Brazil., Rogério Cardozo Kanaji P; Disabled Children's Care Association of São Paulo (AACD-SP), São Paulo 04027-000, Brazil., Serafini Barcellos D; Disabled Children's Care Association of São Paulo (AACD-SP), São Paulo 04027-000, Brazil., Zabulon S; Disabled Children's Care Association of São Paulo (AACD-SP), São Paulo 04027-000, Brazil., de Oliveira Saraiva A; Disabled Children's Care Association of São Paulo (AACD-SP), São Paulo 04027-000, Brazil., Yoshi de Freitas TA; Disabled Children's Care Association of São Paulo (AACD-SP), São Paulo 04027-000, Brazil.
المصدر: Children (Basel, Switzerland) [Children (Basel)] 2023 Dec 15; Vol. 10 (12). Date of Electronic Publication: 2023 Dec 15.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: MDPI AG Country of Publication: Switzerland NLM ID: 101648936 Publication Model: Electronic Cited Medium: Print ISSN: 2227-9067 (Print) Linking ISSN: 22279067 NLM ISO Abbreviation: Children (Basel) Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: Basel, Switzerland : MDPI AG, [2014]-
مستخلص: Surgical treatment is indicated for hip dislocation in patients with cerebral palsy (CP), but it requires care due to the state of nutrition and associated clinical comorbidities. The use of resources that minimize blood loss and the need for blood transfusions are essential to avoid complications. Tranexamic acid (TXA) has been highlighted for orthopedic surgeries to control intraoperative bleeding; however, there is a lack of large studies for its use in hip surgeries in patients with CP. This study aims to evaluate the efficacy and safety of tranexamic acid to reduce bleeding in pediatric patients with cerebral palsy undergoing surgical treatment for hip instability. A sample of 31 patients with CP who underwent surgical treatment for hip dislocation (hip adductor stretching, varization osteotomy of the proximal femur and acetabuloplasty using the Dega technique) was randomly divided into groups: control ( n = 10) and TXA ( n = 21). Preoperative and 24 h hemoglobin concentrations, the length of hospital stay (LHS), and intraoperative bleeding (IB) were analyzed. TXA significantly reduced the IB ( p = 0.02). The variance in hemoglobin concentration was lower for the TXA group, but without statistical significance ( p = 0.06). There was no difference in LHS. Also, no statistical difference was observed for the number of transfusions ( p = 0.08). The findings provide evidence of the effectiveness of TXA in decreasing intraoperative bleeding and its safety for use in pediatric patients with cerebral palsy.
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فهرسة مساهمة: Keywords: bleeding; cerebral palsy; hip dislocation; hip reconstruction; tranexamic acid
تواريخ الأحداث: Date Created: 20231223 Latest Revision: 20231225
رمز التحديث: 20231225
مُعرف محوري في PubMed: PMC10742497
DOI: 10.3390/children10121931
PMID: 38136133
قاعدة البيانات: MEDLINE
الوصف
تدمد:2227-9067
DOI:10.3390/children10121931