دورية أكاديمية
Vagal Stimulation Ameliorates Non-Alcoholic Fatty Liver Disease in Rats.
العنوان: | Vagal Stimulation Ameliorates Non-Alcoholic Fatty Liver Disease in Rats. |
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المؤلفون: | Elkattawy HA; Department of Basic Medical Sciences, College of Medicine, AlMaarefa University, Riyadh 11579, Saudi Arabia.; Medical Physiology Department, College of Medicine, Zagazig University, Zagazig P.O. Box 44519, Egypt., Mahmoud SM; Department of Human Anatomy and Embryology, College of Medicine, Zagazig University, Zagazig P.O. Box 44519, Egypt., Hassan AE; Medical Physiology Department, College of Medicine, Zagazig University, Zagazig P.O. Box 44519, Egypt.; Department of Basic Medical Sciences, College of Medicine, Sulaiman Al-Rajhi University, Bukayriah 51941, Saudi Arabia., Behiry A; Department of Tropical Medicine and Endemic Diseases, College of Medicine, Zagazig University, Zagazig P.O. Box 44519, Egypt., Ebrahim HA; Department of Basic Medical Sciences, College of Medicine, Princess Nourah bint Abdulrahman University, Riyadh 11671, Saudi Arabia., Ibrahim AM; Department of Nursing, College of Applied Medical Sciences, Prince Sattam bin Abdulaziz University, Al-Kharj 11942, Saudi Arabia.; Department of Family and Community Health Nursing, Faculty of Nursing, Port Said University, Port Said P.O. Box 42511, Egypt., Zaghamir DEF; Department of Nursing, College of Applied Medical Sciences, Prince Sattam bin Abdulaziz University, Al-Kharj 11942, Saudi Arabia.; Department of Pediatric Nursing, Faculty of Nursing, Port Said University, Port Said P.O. Box 42511, Egypt., El-Sherbiny M; Department of Basic Medical Sciences, College of Medicine, AlMaarefa University, Riyadh 11579, Saudi Arabia., El-Sayed SF; Medical Physiology Department, College of Medicine, Zagazig University, Zagazig P.O. Box 44519, Egypt. |
المصدر: | Biomedicines [Biomedicines] 2023 Dec 08; Vol. 11 (12). Date of Electronic Publication: 2023 Dec 08. |
نوع المنشور: | Journal Article |
اللغة: | English |
بيانات الدورية: | Publisher: MDPI AG Country of Publication: Switzerland NLM ID: 101691304 Publication Model: Electronic Cited Medium: Print ISSN: 2227-9059 (Print) Linking ISSN: 22279059 NLM ISO Abbreviation: Biomedicines Subsets: PubMed not MEDLINE |
أسماء مطبوعة: | Original Publication: Basel, Switzerland : MDPI AG, [2013]- |
مستخلص: | Background: The harmful consequences of non-alcoholic fatty liver disease (NAFLD) are posing an increasing threat to public health as the incidence of diabetes and obesity increases globally. A non-invasive treatment with a range of autonomic and metabolic benefits is transcutaneous vagus nerve stimulation (tVNS). Aim of the Study: To investigate the possible preventive impacts of VNS against adult rats' NAFLD caused by a high-fat diet (HFD) and to clarify the underlying mechanisms. Methods: A total of thirty-two adult male rats were split into two groups: the HFD-induced NAFLD group ( n = 24) and the control normal group ( n = 8). The obesogenic diet was maintained for 12 weeks to induce hepatic steatosis. The HFD-induced NAFLD group ( n = 24) was separated into three groups: the group without treatment ( n = 8), the group with sham stimulation ( n = 8), and the group with VNS treatment ( n = 8). VNS was delivered for 30 min per day for 6 weeks after the establishment of NAFLD using a digital TENS device. The subsequent assessments included hepatic triglyceride, cholesterol content, serum lipid profile, and liver function testing. In this context, inflammatory biomarkers (TNF-α, IL-6) and hepatic oxidative stress (MDA, SOD, and GPx) were also assessed. To clarify the possible mechanisms behind the protective benefits of VNS, additional histological inspection and immunohistochemistry analysis of TNF-α and Caspase-3 were performed. Results: In the NAFLD-affected obese rats, VNS markedly decreased the rats' body mass index (BMI) and abdominal circumference (AC). Liver function markers (albumin, ALT, and AST) and the serum lipid profile-which included a notable decrease in the amounts of hepatic triglycerides and cholesterol-were both markedly improved. Additionally, oxidative stress and inflammatory indicators showed a considerable decline with VNS. Notably, the liver tissues examined by histopathologists revealed that there is evidence of the protective impact of VNS on the oxidative and inflammatory states linked to HFD-induced NAFLD while maintaining the architectural and functional condition of the liver. Conclusions: Our findings suggest that VNS may represent a promising therapeutic candidate for managing NAFLD induced by obesity. It can be considered to be an effective adjuvant physiological intervention for the obese population with NAFLD to spare the liver against obesity-induced deleterious injury. |
References: | Brain Stimul. 2014 Nov-Dec;7(6):871-7. (PMID: 25164906) Heart Fail Rev. 2011 Mar;16(2):163-9. (PMID: 20623184) Clin Chem. 1972 Jun;18(6):499-502. (PMID: 4337382) Med Sci Monit. 2015 Jan 21;21:268-75. (PMID: 25619160) Gastroenterology. 2016 Jun;150(8):1769-77. (PMID: 26928243) BMC Endocr Disord. 2022 Mar 14;22(1):63. (PMID: 35287643) Front Neurosci. 2021 Mar 22;15:650971. (PMID: 33828455) Cell Death Dis. 2020 Nov 12;11(11):971. (PMID: 33184264) Circ Heart Fail. 2014 Nov;7(6):1014-21. (PMID: 25332149) Diabetes Care. 2000 Jan;23(1):57-63. (PMID: 10857969) J Clin Invest. 2017 Jan 3;127(1):1-4. (PMID: 28045402) Clin Chem. 1973 Mar;19(3):338-40. (PMID: 4347544) Sci Rep. 2016 Feb 01;6:19749. (PMID: 26830020) J Physiol. 2016 Oct 15;594(20):5791-5815. (PMID: 26959077) Curr Hypertens Rep. 2010 Apr;12(2):99-104. (PMID: 20424938) Nat Rev Gastroenterol Hepatol. 2019 Jun;16(6):377-386. (PMID: 31024089) Nutrition. 2015 Nov-Dec;31(11-12):1416-22. (PMID: 26429664) Biol Psychiatry. 2000 Feb 15;47(4):287-95. (PMID: 10686263) Physiol Res. 2022 Nov 28;71(5):615-630. (PMID: 36047723) Cell Metab. 2014 Apr 1;19(4):722-30. (PMID: 24703703) J Lab Clin Med. 1967 Jul;70(1):158-69. (PMID: 6066618) Hepatology. 2005 Jun;41(6):1313-21. (PMID: 15915461) Diabetes Care. 2003 Nov;26(11):3035-41. (PMID: 14578236) Biomedicines. 2023 Feb 06;11(2):. (PMID: 36831004) Clin Gastroenterol Hepatol. 2015 Nov;13(12):2062-70. (PMID: 26226097) J Biol Chem. 1972 May 25;247(10):3170-5. (PMID: 4623845) Brain Stimul. 2016 Mar-Apr;9(2):166-73. (PMID: 26723020) Curr Issues Mol Biol. 2023 Aug 12;45(8):6651-6666. (PMID: 37623239) J Biol Chem. 1957 May;226(1):497-509. (PMID: 13428781) Hepatology. 2004 Dec;40(6):1387-95. (PMID: 15565570) Brain Stimul. 2017 Sep - Oct;10(5):875-881. (PMID: 28566194) Appetite. 2010 Oct;55(2):245-52. (PMID: 20600417) Biol Res. 2008;41(3):253-9. (PMID: 19399338) Biomolecules. 2015 Jul 21;5(3):1563-79. (PMID: 26197341) Pharmacol Ther. 2021 Jun;222:107794. (PMID: 33310156) Lab Anim. 2007 Jan;41(1):111-9. (PMID: 17234057) J Am Coll Cardiol. 2015 Mar 10;65(9):867-75. (PMID: 25744003) Diabetes. 2017 Apr;66(4):848-857. (PMID: 28082456) PLoS One. 2013 Oct 23;8(10):e77221. (PMID: 24194874) Auton Neurosci. 2016 Aug;199:48-53. (PMID: 27388046) Br J Pharmacol. 2015 Nov;172(22):5225-38. (PMID: 26403657) PLoS One. 2015 Apr 16;10(4):e0124195. (PMID: 25880500) Neuro Endocrinol Lett. 2013;34(4):314-21. (PMID: 23803866) J Psychiatr Res. 2003 Nov-Dec;37(6):443-55. (PMID: 14563375) Sci Rep. 2021 May 17;11(1):10394. (PMID: 34001925) J Clin Invest. 2011 Jun;121(6):2111-7. (PMID: 21633179) Nutr Metab (Lond). 2016 Feb 25;13:15. (PMID: 26918024) |
معلومات مُعتمدة: | PSAU/2023/R/1444 Prince Sattam bin Abulaziz University; PNURSP2023R171 Princess Nourah bint Abdulrahman University |
فهرسة مساهمة: | Keywords: high-fat diet; non-alcoholic fatty liver; obesity; vagus nerve |
تواريخ الأحداث: | Date Created: 20231223 Latest Revision: 20231225 |
رمز التحديث: | 20231225 |
مُعرف محوري في PubMed: | PMC10741668 |
DOI: | 10.3390/biomedicines11123255 |
PMID: | 38137476 |
قاعدة البيانات: | MEDLINE |
تدمد: | 2227-9059 |
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DOI: | 10.3390/biomedicines11123255 |