دورية أكاديمية
أعرض في EDS

Role of Telomere Length in Survival of Patients with Idiopathic Pulmonary Fibrosis and Other Interstitial Lung Diseases.

التفاصيل البيبلوغرافية
العنوان: Role of Telomere Length in Survival of Patients with Idiopathic Pulmonary Fibrosis and Other Interstitial Lung Diseases.
المؤلفون: Tesolato S; Department of Biochemistry and Molecular Biology, Faculty of Pharmacy, Complutense University, Ramón y Cajal Sq. (University City), 28040 Madrid, Spain.; San Carlos Health Research Institute (IdISSC), 28040 Madrid, Spain., Vicente-Valor J; Department of Biochemistry and Molecular Biology, Faculty of Pharmacy, Complutense University, Ramón y Cajal Sq. (University City), 28040 Madrid, Spain.; San Carlos Health Research Institute (IdISSC), 28040 Madrid, Spain., Jarabo JR; San Carlos Health Research Institute (IdISSC), 28040 Madrid, Spain.; Department of Surgery, Faculty of Medicine, Complutense University, Ramón y Cajal Sq. (University City), 28040 Madrid, Spain.; Thoracic Surgery Service of the San Carlos Hospital, 28040 Madrid, Spain., Calatayud J; San Carlos Health Research Institute (IdISSC), 28040 Madrid, Spain.; Department of Surgery, Faculty of Medicine, Complutense University, Ramón y Cajal Sq. (University City), 28040 Madrid, Spain.; Thoracic Surgery Service of the San Carlos Hospital, 28040 Madrid, Spain., Sáiz-Pardo M; Pathological Anatomy Service of the San Carlos Hospital, 28040 Madrid, Spain., Nieto A; Pulmonology Service of the San Carlos Hospital, 28040 Madrid, Spain., Álvaro-Álvarez D; Pulmonology Service of the Mostoles University Hospital, 28935 Madrid, Spain., Linares MJ; Pulmonology Service of Alcorcon Foundation University Hospital, 28922 Madrid, Spain., Fraile CA; San Carlos Health Research Institute (IdISSC), 28040 Madrid, Spain.; Department of Surgery, Faculty of Medicine, Complutense University, Ramón y Cajal Sq. (University City), 28040 Madrid, Spain.; Thoracic Surgery Service of the San Carlos Hospital, 28040 Madrid, Spain., Hernándo F; San Carlos Health Research Institute (IdISSC), 28040 Madrid, Spain.; Department of Surgery, Faculty of Medicine, Complutense University, Ramón y Cajal Sq. (University City), 28040 Madrid, Spain.; Thoracic Surgery Service of the San Carlos Hospital, 28040 Madrid, Spain., Iniesta P; Department of Biochemistry and Molecular Biology, Faculty of Pharmacy, Complutense University, Ramón y Cajal Sq. (University City), 28040 Madrid, Spain.; San Carlos Health Research Institute (IdISSC), 28040 Madrid, Spain., Gómez-Martínez AM; San Carlos Health Research Institute (IdISSC), 28040 Madrid, Spain.; Department of Surgery, Faculty of Medicine, Complutense University, Ramón y Cajal Sq. (University City), 28040 Madrid, Spain.; Thoracic Surgery Service of the San Carlos Hospital, 28040 Madrid, Spain.
المصدر: Biomedicines [Biomedicines] 2023 Dec 08; Vol. 11 (12). Date of Electronic Publication: 2023 Dec 08.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: MDPI AG Country of Publication: Switzerland NLM ID: 101691304 Publication Model: Electronic Cited Medium: Print ISSN: 2227-9059 (Print) Linking ISSN: 22279059 NLM ISO Abbreviation: Biomedicines Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: Basel, Switzerland : MDPI AG, [2013]-
مستخلص: Interstitial lung diseases (ILDs) constitute a group of more than 200 disorders, with idiopathic pulmonary fibrosis (IPF) being one of the most frequent. Telomere length (TL) shortening causes loss of function of the lung parenchyma. However, little is known about its role as a prognostic factor in ILD patients. With the aim of investigating the role of TL and telomerase activity in the prognosis of patients affected by ILDs, we analysed lung tissue samples from 61 patients. We measured relative TL and telomerase activity by conventional procedures. Both clinical and molecular parameters were associated with overall survival by the Kaplan-Meier method. Patients with IPF had poorer prognosis than patients with other ILDs ( p = 0.034). When patients were classified according to TL, those with shortened telomeres reported lower overall survival ( p = 0.085); differences reached statistical significance after excluding ILD patients who developed cancer ( p = 0.021). In a Cox regression analysis, TL behaved as a risk-modifying variable for death associated with rheumatic disease (RD) co-occurrence ( p = 0.029). Also, in patients without cancer, ferritin was significantly increased in cases with RD and IPF co-occurrence ( p = 0.032). In relation to telomerase activity, no significant differences were detected. In conclusion, TL in lung tissue emerges as a prognostic factor in ILD patients. Specifically, in cases with RD and IPF co-occurrence, TL can be considered as a risk-modifying variable for death.
References: Adv Respir Med. 2023 Jan 31;91(1):26-48. (PMID: 36825939)
Pulmonology. 2022 Jul-Aug;28(4):254-261. (PMID: 33358512)
Mutat Res. 2012 Feb 1;730(1-2):52-8. (PMID: 22079513)
PLoS One. 2012;7(12):e51862. (PMID: 23251644)
Eur Respir J. 2016 Dec;48(6):1710-1720. (PMID: 27540018)
Nucleic Acids Res. 2001 May 1;29(9):e45. (PMID: 11328886)
Biochem Biophys Res Commun. 2007 Oct 26;362(3):707-11. (PMID: 17720141)
Cell. 2005 Dec 16;123(6):1121-31. (PMID: 16360040)
Ann Am Thorac Soc. 2019 Feb;16(2):175-181. (PMID: 30540921)
Proc Natl Acad Sci U S A. 2008 Sep 2;105(35):13051-6. (PMID: 18753630)
Nucleic Acids Res. 1976 Sep;3(9):2303-8. (PMID: 987581)
Respiration. 2007;74(2):159-69. (PMID: 17108669)
EBioMedicine. 2023 Sep;95:104766. (PMID: 37625268)
Respirology. 2022 Jul;27(7):539-548. (PMID: 35513341)
Am J Respir Crit Care Med. 2000 Feb;161(2 Pt 1):646-64. (PMID: 10673212)
Proc Natl Acad Sci U S A. 2015 Apr 21;112(16):5099-104. (PMID: 25840590)
BMJ Open Respir Res. 2023 Jun;10(1):. (PMID: 37308252)
Am J Respir Crit Care Med. 2019 Aug 1;200(3):336-347. (PMID: 30566847)
Nucleic Acids Res. 2002 May 15;30(10):e47. (PMID: 12000852)
Exp Gerontol. 2023 Apr;174:112132. (PMID: 36849001)
Curr Opin Pulm Med. 2018 Sep;24(5):440-444. (PMID: 30067250)
Lancet Respir Med. 2014 Jul;2(7):557-65. (PMID: 24948432)
Front Med (Lausanne). 2021 Nov 11;8:739810. (PMID: 34859008)
Kaohsiung J Med Sci. 2019 Jun;35(6):365-372. (PMID: 30913371)
JAMA Intern Med. 2022 Mar 01;182(3):291-300. (PMID: 35040871)
Eur Respir J. 2001 Feb;17(2):175-9. (PMID: 11334116)
Am J Respir Crit Care Med. 2008 Oct 1;178(7):729-37. (PMID: 18635888)
CMAJ. 2004 Jul 20;171(2):153-60. (PMID: 15262886)
Pulm Pharmacol Ther. 2008;21(1):26-31. (PMID: 17161968)
Am J Respir Crit Care Med. 2022 May 1;205(9):e18-e47. (PMID: 35486072)
Lancet. 2022 Sep 3;400(10354):769-786. (PMID: 35964592)
Respir Res. 2018 Jul 9;19(1):132. (PMID: 29986708)
Front Med (Lausanne). 2021 May 10;8:680997. (PMID: 34041256)
J Clin Med. 2022 Mar 21;11(6):. (PMID: 35330072)
Eur Respir Rev. 2018 Dec 21;27(150):. (PMID: 30578335)
Eur Respir J. 2010 Jun;35(6):1322-8. (PMID: 19996193)
Respirology. 2015 Aug;20(6):947-52. (PMID: 26073170)
Nat Rev Genet. 2019 May;20(5):299-309. (PMID: 30760854)
PLoS One. 2014 Jan 27;9(1):e87348. (PMID: 24475279)
Nat Commun. 2023 Mar 17;14(1):1489. (PMID: 36932145)
Eur Respir J. 2023 Apr 20;61(4):. (PMID: 36702498)
Eur Respir J. 2002 Jun;19(6):1114-8. (PMID: 12108865)
Arthritis Rheum. 2005 Aug 15;53(4):549-57. (PMID: 16082627)
Nat Commun. 2014 Jun 24;2:4172. (PMID: 24960204)
معلومات مُعتمدة: 2019 and 2020, respectively "Neumomadrid" (Sociedad Madrileña de Neumología y Cirugía Torácica), and "Cátedra EPID Futuro UAM-Roche".
فهرسة مساهمة: Keywords: idiopathic pulmonary fibrosis; interstitial lung diseases; prognosis; telomere length
تواريخ الأحداث: Date Created: 20231223 Latest Revision: 20231225
رمز التحديث: 20231225
مُعرف محوري في PubMed: PMC10741059
DOI: 10.3390/biomedicines11123257
PMID: 38137478
قاعدة البيانات: MEDLINE
الوصف
تدمد:2227-9059
DOI:10.3390/biomedicines11123257