دورية أكاديمية

Sex, Endothelial Cell Functions, and Peripheral Artery Disease.

التفاصيل البيبلوغرافية
العنوان: Sex, Endothelial Cell Functions, and Peripheral Artery Disease.
المؤلفون: Cartland SP; Heart Research Institute, The University of Sydney, Sydney, NSW 2042, Australia., Stanley CP; Heart Research Institute, The University of Sydney, Sydney, NSW 2042, Australia., Bursill C; South Australian Health and Medical Research Institute, Adelaide, SA 5000, Australia.; Adelaide Medical School, University of Adelaide, Adelaide, SA 5005, Australia., Passam F; Faculty of Health and Medicine, The University of Sydney, Sydney, NSW 2050, Australia., Figtree GA; Faculty of Health and Medicine, The University of Sydney, Sydney, NSW 2050, Australia.; Kolling Institute of Medical Research, Sydney, NSW 2064, Australia., Patel S; Heart Research Institute, The University of Sydney, Sydney, NSW 2042, Australia.; Royal Prince Alfred Hospital, Sydney, NSW 2050, Australia., Loa J; Royal Prince Alfred Hospital, Sydney, NSW 2050, Australia., Golledge J; Queensland Research Centre for Peripheral Vascular Disease, College of Medicine and Dentistry, James Cook University, Townsville, QLD 4811, Australia.; Department of Vascular and Endovascular Surgery, The Townsville University Hospital, Townsville, QLD 4814, Australia., Robinson DA; Royal Prince Alfred Hospital, Sydney, NSW 2050, Australia., Aitken SJ; Faculty of Health and Medicine, The University of Sydney, Sydney, NSW 2050, Australia.; Concord Institute of Academic Surgery, Concord Repatriation General Hospital, Sydney, NSW 2139, Australia., Kavurma MM; Heart Research Institute, The University of Sydney, Sydney, NSW 2042, Australia.
المصدر: International journal of molecular sciences [Int J Mol Sci] 2023 Dec 13; Vol. 24 (24). Date of Electronic Publication: 2023 Dec 13.
نوع المنشور: Journal Article; Review
اللغة: English
بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067 (Electronic) Linking ISSN: 14220067 NLM ISO Abbreviation: Int J Mol Sci Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Basel, Switzerland : MDPI, [2000-
مواضيع طبية MeSH: Peripheral Arterial Disease*/therapy , Atherosclerosis*, Male ; Humans ; Female ; Lower Extremity/blood supply ; Intermittent Claudication ; Endothelial Cells ; Risk Factors
مستخلص: Peripheral artery disease (PAD) is caused by blocked arteries due to atherosclerosis and/or thrombosis which reduce blood flow to the lower limbs. It results in major morbidity, including ischemic limb, claudication, and amputation, with patients also suffering a heightened risk of heart attack, stroke, and death. Recent studies suggest women have a higher prevalence of PAD than men, and with worse outcomes after intervention. In addition to a potential unconscious bias faced by women with PAD in the health system, with underdiagnosis, and lower rates of guideline-based therapy, fundamental biological differences between men and women may be important. In this review, we highlight sexual dimorphisms in endothelial cell functions and how they may impact PAD pathophysiology in women. Understanding sex-specific mechanisms in PAD is essential for the development of new therapies and personalized care for patients with PAD.
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فهرسة مساهمة: Keywords: endothelial cell dysfunction; peripheral artery disease; sex differences
تواريخ الأحداث: Date Created: 20231223 Date Completed: 20231225 Latest Revision: 20231225
رمز التحديث: 20231225
مُعرف محوري في PubMed: PMC10744086
DOI: 10.3390/ijms242417439
PMID: 38139267
قاعدة البيانات: MEDLINE
الوصف
تدمد:1422-0067
DOI:10.3390/ijms242417439