دورية أكاديمية
أعرض في EDS

Synephrine and Its Derivative Compound A: Common and Specific Biological Effects.

التفاصيل البيبلوغرافية
العنوان: Synephrine and Its Derivative Compound A: Common and Specific Biological Effects.
المؤلفون: Dodonova SA; Research Institute of Experimental Medicine, Department of Pathophysiology, Kursk State Medical University, 305041 Kursk, Russia., Zhidkova EM; Department of Chemical Carcinogenesis, N.N. Blokhin National Medical Research Center of Oncology, 115478 Moscow, Russia., Kryukov AA; Research Institute of Experimental Medicine, Department of Pathophysiology, Kursk State Medical University, 305041 Kursk, Russia., Valiev TT; Department of Chemical Carcinogenesis, N.N. Blokhin National Medical Research Center of Oncology, 115478 Moscow, Russia., Kirsanov KI; Department of Chemical Carcinogenesis, N.N. Blokhin National Medical Research Center of Oncology, 115478 Moscow, Russia.; Faculty of Oncology, Ryazan State Medical University Named after Academician I.P. Pavlov, 390026 Ryazan, Russia., Kulikov EP; Laboratory of Single Cell Biology, Russian University of People's Friendship (RUDN) University, 117198 Moscow, Russia., Budunova IV; Department of Dermatology, Northwestern University, Chicago, IL 60611, USA., Yakubovskaya MG; Department of Chemical Carcinogenesis, N.N. Blokhin National Medical Research Center of Oncology, 115478 Moscow, Russia.; Faculty of Oncology, Ryazan State Medical University Named after Academician I.P. Pavlov, 390026 Ryazan, Russia., Lesovaya EA; Department of Chemical Carcinogenesis, N.N. Blokhin National Medical Research Center of Oncology, 115478 Moscow, Russia.; Faculty of Oncology, Ryazan State Medical University Named after Academician I.P. Pavlov, 390026 Ryazan, Russia.; Laboratory of Single Cell Biology, Russian University of People's Friendship (RUDN) University, 117198 Moscow, Russia.
المصدر: International journal of molecular sciences [Int J Mol Sci] 2023 Dec 15; Vol. 24 (24). Date of Electronic Publication: 2023 Dec 15.
نوع المنشور: Journal Article; Review
اللغة: English
بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067 (Electronic) Linking ISSN: 14220067 NLM ISO Abbreviation: Int J Mol Sci Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Basel, Switzerland : MDPI, [2000-
مواضيع طبية MeSH: Synephrine*/adverse effects , Citrus*/metabolism, Animals ; Receptors, Glucocorticoid/metabolism ; Plant Extracts/pharmacology ; Anti-Inflammatory Agents
مستخلص: This review is focused on synephrine, the principal phytochemical found in bitter orange and other medicinal plants and widely used as a dietary supplement for weight loss/body fat reduction. We examine different aspects of synephrine biology, delving into its established and potential molecular targets, as well as its mechanisms of action. We present an overview of the origin, chemical composition, receptors, and pharmacological properties of synephrine, including its anti-inflammatory and anti-cancer activity in various in vitro and animal models. Additionally, we conduct a comparative analysis of the molecular targets and effects of synephrine with those of its metabolite, selective glucocorticoid receptor agonist (SEGRA) Compound A (CpdA), which shares a similar chemical structure with synephrine. SEGRAs, including CpdA, have been extensively studied as glucocorticoid receptor activators that have a better benefit/risk profile than glucocorticoids due to their reduced adverse effects. We discuss the potential of synephrine usage as a template for the synthesis of new generation of non-steroidal SEGRAs. The review also provides insights into the safe pharmacological profile of synephrine.
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معلومات مُعتمدة: 23-15-00321 Russian Science Foundation
فهرسة مساهمة: Keywords: CpdA; beta-adrenergic receptors; cancer; cardiovascular system; glucocorticoids; inflammation; metabolic disorders; selective glucocorticoid receptor activator; synephrine
المشرفين على المادة: PEG5DP7434 (Synephrine)
0 (Receptors, Glucocorticoid)
0 (Plant Extracts)
0 (Anti-Inflammatory Agents)
تواريخ الأحداث: Date Created: 20231223 Date Completed: 20231225 Latest Revision: 20231225
رمز التحديث: 20231225
مُعرف محوري في PubMed: PMC10744207
DOI: 10.3390/ijms242417537
PMID: 38139366
قاعدة البيانات: MEDLINE
الوصف
تدمد:1422-0067
DOI:10.3390/ijms242417537