دورية أكاديمية
Novel Organogels from Mauritia flexuosa L.f and Caryodendron orinocense Karst.: A Topical Alternative.
| العنوان: | Novel Organogels from Mauritia flexuosa L.f and Caryodendron orinocense Karst.: A Topical Alternative. |
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| المؤلفون: | Narvaez LEM; Institute of Health Sciences, Federal University of Pará, Belém 66075-110, Brazil.; Sinchi Amazon Research Institute, Bogotá 110311, Colombia., Carrillo MP; Sinchi Amazon Research Institute, Bogotá 110311, Colombia., Cardona-Jaramillo JEC; Sinchi Amazon Research Institute, Bogotá 110311, Colombia., Vallejo BM; Health Sciences Institute, National University of Colombia, Bogotá 111321, Colombia., Ferreira LMMC; Institute of Health Sciences, Federal University of Pará, Belém 66075-110, Brazil., Silva-Júnior JOC; Institute of Health Sciences, Federal University of Pará, Belém 66075-110, Brazil., Ribeiro-Costa RM; Institute of Health Sciences, Federal University of Pará, Belém 66075-110, Brazil. |
| المصدر: | Pharmaceutics [Pharmaceutics] 2023 Nov 27; Vol. 15 (12). Date of Electronic Publication: 2023 Nov 27. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: MDPI Country of Publication: Switzerland NLM ID: 101534003 Publication Model: Electronic Cited Medium: Print ISSN: 1999-4923 (Print) Linking ISSN: 19994923 NLM ISO Abbreviation: Pharmaceutics Subsets: PubMed not MEDLINE |
| أسماء مطبوعة: | Original Publication: Basel, Switzerland : MDPI |
| مستخلص: | Organogels have importance for topical applications because they can be used to deliver drugs in a controlled and prolonged fashion. These are materials consisting of a three-dimensional network of organic molecules dispersed in a solvent. Recent studies have demonstrated that the solvent could be replaced by oils from non-conventional biologic sources. There is a diversity of not-explored species in the Amazon that are promising sources of vegetable oils with a promising composition. This study developed an organogel with buriti ( Mauritia flexuosa L.f) and cacay ( Caryodendron orinocens e Karst.) oils, using cetostearyl alcohol as an organogelator due to its compatibility, stability, security, affordability, and it is readily available. The oils were characterized, and the organogels were synthesized by studying their crystal evolution and oil-binding capacity. The microstructure was evaluated with polarized light microscopy, fractal dimension, FTIR spectroscopy, XRD, and thermal and rheological analyses. It was found that the critical gelation concentration was higher for cacay oil as it possessed a higher amount of polyunsaturated triacylglycerols. The crystals of the buriti organogel had a smaller lamellar shape, a greater surface area, and physical and thermal stability; although, it presented a slower crystal evolution due to the low number of minor compounds and a greater number of saturated triacylglycerols. The polar fraction of the organogelators as well as triacylglycerol and minor polar compounds are important in forming crystallization nuclei. The study showed that Amazonian oils in crystallization processes form microstructures with differentiating physicochemical properties. |
| References: | AAPS PharmSciTech. 2015 Apr;16(2):293-305. (PMID: 25277240) Phytomedicine. 2011 Dec 15;19(1):64-73. (PMID: 22115797) Food Chem Toxicol. 2008 Aug;46(8):2776-81. (PMID: 18558457) Mater Sci Eng C Mater Biol Appl. 2015 Mar;48:688-99. (PMID: 25579972) Food Chem. 2014 Apr 15;149:62-70. (PMID: 24295677) Biotechnol Rep (Amst). 2019 Aug 08;24:e00365. (PMID: 31463206) Materials (Basel). 2019 Jun 12;12(12):. (PMID: 31212767) Expert Opin Drug Deliv. 2005 May;2(3):489-505. (PMID: 16296770) Biomolecules. 2023 Jun 13;13(6):. (PMID: 37371565) J Control Release. 2008 Feb 11;125(3):179-92. (PMID: 18082283) Food Res Int. 2017 Jun;96:161-170. (PMID: 28528095) Top Curr Chem. 2005;256:1-37. (PMID: 22160335) J Oleo Sci. 2012;61(1):1-9. (PMID: 22188800) Food Chem. 2022 Jan 30;368:130779. (PMID: 34411852) Gels. 2021 Jul 19;7(3):. (PMID: 34287321) Food Res Int. 2019 Jun;120:610-619. (PMID: 31000278) Arch Latinoam Nutr. 1994 Sep;44(3):172-5. (PMID: 7786101) Gels. 2022 Jan 05;8(1):. (PMID: 35049573) Int J Cosmet Sci. 2019 Apr;41(2):109-117. (PMID: 30994939) Int J Cosmet Sci. 2020 Oct;42(5):494-500. (PMID: 32696456) Foods. 2022 Oct 08;11(19):. (PMID: 36230203) J Oleo Sci. 2014;63(12):1243-50. (PMID: 25391685) ScientificWorldJournal. 2018 Jul 3;2018:5283753. (PMID: 30057491) Gels. 2022 Jan 09;8(1):. (PMID: 35049583) Int J Biol Macromol. 2020 Aug 1;156:792-804. (PMID: 32302632) Mar Drugs. 2019 Dec 06;17(12):. (PMID: 31817709) Food Chem. 2021 Aug 30;354:129534. (PMID: 33752116) Food Chem. 2021 Oct 30;360:130017. (PMID: 33984566) Molecules. 2022 Apr 24;27(9):. (PMID: 35566084) Int J Cosmet Sci. 1999 Jun;21(3):151-8. (PMID: 18505537) |
| معلومات مُعتمدة: | 2020000100264 SGR VAUPÉS |
| فهرسة مساهمة: | Keywords: Caryodendron orinocense; Mauritia flexuosa; cetostearyl alcohol; natural ingredients; organogel; topical application |
| تواريخ الأحداث: | Date Created: 20231223 Latest Revision: 20231225 |
| رمز التحديث: | 20231225 |
| مُعرف محوري في PubMed: | PMC10747660 |
| DOI: | 10.3390/pharmaceutics15122681 |
| PMID: | 38140024 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1999-4923 |
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| DOI: | 10.3390/pharmaceutics15122681 |