دورية أكاديمية
Sustainable Treatment of Oral Traumatic Ulcers with Licorice Containing Hydrogels: Integrating Computational Modeling, Quality by Design, Green Synthesis, and Molecular Biological Evaluation.
العنوان: | Sustainable Treatment of Oral Traumatic Ulcers with Licorice Containing Hydrogels: Integrating Computational Modeling, Quality by Design, Green Synthesis, and Molecular Biological Evaluation. |
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المؤلفون: | Moussa SG; Department of Oral Medicine, Periodontology, and Diagnosis, Faculty of Oral and Dental Medicine, Future University in Egypt, Cairo 11835, Egypt., El Hoffy NM; Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, Future University in Egypt, Cairo 11835, Egypt., Mouselhy YY; Department of Oral Pathology, Faculty of Oral and Dental Medicine, Future University in Egypt, Cairo 11835, Egypt., Mubarak R; Department of Oral Medicine, Periodontology, and Diagnosis, Faculty of Oral and Dental Medicine, Future University in Egypt, Cairo 11835, Egypt., Attia RT; Department of Pharmacology and Toxicology and Biochemistry, Faculty of Pharmacy, Future University in Egypt, Cairo 11835, Egypt., Khalil N; Department of Pharmacognosy and Medicinal Plants, Faculty of Pharmacy, Future University in Egypt, Cairo 11835, Egypt., Amer SA; Department of Oral Medicine, Periodontology, and Diagnosis, Faculty of Oral and Dental Medicine, Future University in Egypt, Cairo 11835, Egypt. |
المصدر: | Pharmaceutics [Pharmaceutics] 2023 Dec 06; Vol. 15 (12). Date of Electronic Publication: 2023 Dec 06. |
نوع المنشور: | Journal Article |
اللغة: | English |
بيانات الدورية: | Publisher: MDPI Country of Publication: Switzerland NLM ID: 101534003 Publication Model: Electronic Cited Medium: Print ISSN: 1999-4923 (Print) Linking ISSN: 19994923 NLM ISO Abbreviation: Pharmaceutics Subsets: PubMed not MEDLINE |
أسماء مطبوعة: | Original Publication: Basel, Switzerland : MDPI |
مستخلص: | The urge to implement innovative approaches that align with eco-friendly practices and hold promise for enhancing oral health while promoting environmental sustainability has been increasing. This current work aims to develop a sustainable treatment for oral traumatic ulcers using licorice-based hydrogels (LHGs) containing hydroxyethyl cellulose (HEC) as the green gelling agent. Licorice root aqueous extract was phytochemically profiled using UPLC-ESI-MS/MS. Forty-three compounds were detected, with Glycyrrhizic acid being the major component of the extract (34.85 ± 2.77%). By implementing a Quality by Design (QbD) approach, the study investigates the effects of different licorice extract and HEC concentrations on key variables such as pH and viscosity of the prepared formulations, ulcer and wound healing scores, and tissue growth factors via a Full Factorial Experimental Design. The LHGs exhibited desirable consistency, spreadability, and clarity. Statistical analysis, employing an ANOVA test, revealed the high significance of the constructed models with the licorice concentration being the key independent factor affecting all dependent outputs. The pH as well as the viscosity of the prepared LHGs were positively influenced by licorice extract concentration, with higher concentrations leading to increased alkalinity and viscosity. Rheological behavior analysis revealed a pseudoplastic flow with demonstrated thixotropy which is advantageous for application and prolongation of residence time. The wound healing process was assessed through ulcer size, traumatic ulcer healing score (UHS), collagen-1 expression (COL-1), growth factors (EGF, VEGF), pro-inflammatory markers (TNF-α), wound healing score (WHS). LHGs prepared using higher levels of both factors, 30% dried licorice root extract and 4% HEC, demonstrated enhanced wound healing, elevated growth factor expression of 66.67% and 23.24%, respectively, and 88% reduced inflammation compared to the control group, indicating their potential in expediting oral ulcer recovery. Overall, these findings highlight the promising role of green licorice-based hydrogels in promoting sustainable oral mucosal healing. |
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فهرسة مساهمة: | Keywords: green synthesis; hydrogels; hydroxyethyl cellulose; licorice; oral ulcer; sustainability |
تواريخ الأحداث: | Date Created: 20231223 Latest Revision: 20231225 |
رمز التحديث: | 20231225 |
مُعرف محوري في PubMed: | PMC10748055 |
DOI: | 10.3390/pharmaceutics15122734 |
PMID: | 38140075 |
قاعدة البيانات: | MEDLINE |
تدمد: | 1999-4923 |
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DOI: | 10.3390/pharmaceutics15122734 |