دورية أكاديمية
أعرض في EDS

Sustainable Treatment of Oral Traumatic Ulcers with Licorice Containing Hydrogels: Integrating Computational Modeling, Quality by Design, Green Synthesis, and Molecular Biological Evaluation.

التفاصيل البيبلوغرافية
العنوان: Sustainable Treatment of Oral Traumatic Ulcers with Licorice Containing Hydrogels: Integrating Computational Modeling, Quality by Design, Green Synthesis, and Molecular Biological Evaluation.
المؤلفون: Moussa SG; Department of Oral Medicine, Periodontology, and Diagnosis, Faculty of Oral and Dental Medicine, Future University in Egypt, Cairo 11835, Egypt., El Hoffy NM; Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, Future University in Egypt, Cairo 11835, Egypt., Mouselhy YY; Department of Oral Pathology, Faculty of Oral and Dental Medicine, Future University in Egypt, Cairo 11835, Egypt., Mubarak R; Department of Oral Medicine, Periodontology, and Diagnosis, Faculty of Oral and Dental Medicine, Future University in Egypt, Cairo 11835, Egypt., Attia RT; Department of Pharmacology and Toxicology and Biochemistry, Faculty of Pharmacy, Future University in Egypt, Cairo 11835, Egypt., Khalil N; Department of Pharmacognosy and Medicinal Plants, Faculty of Pharmacy, Future University in Egypt, Cairo 11835, Egypt., Amer SA; Department of Oral Medicine, Periodontology, and Diagnosis, Faculty of Oral and Dental Medicine, Future University in Egypt, Cairo 11835, Egypt.
المصدر: Pharmaceutics [Pharmaceutics] 2023 Dec 06; Vol. 15 (12). Date of Electronic Publication: 2023 Dec 06.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101534003 Publication Model: Electronic Cited Medium: Print ISSN: 1999-4923 (Print) Linking ISSN: 19994923 NLM ISO Abbreviation: Pharmaceutics Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: Basel, Switzerland : MDPI
مستخلص: The urge to implement innovative approaches that align with eco-friendly practices and hold promise for enhancing oral health while promoting environmental sustainability has been increasing. This current work aims to develop a sustainable treatment for oral traumatic ulcers using licorice-based hydrogels (LHGs) containing hydroxyethyl cellulose (HEC) as the green gelling agent. Licorice root aqueous extract was phytochemically profiled using UPLC-ESI-MS/MS. Forty-three compounds were detected, with Glycyrrhizic acid being the major component of the extract (34.85 ± 2.77%). By implementing a Quality by Design (QbD) approach, the study investigates the effects of different licorice extract and HEC concentrations on key variables such as pH and viscosity of the prepared formulations, ulcer and wound healing scores, and tissue growth factors via a Full Factorial Experimental Design. The LHGs exhibited desirable consistency, spreadability, and clarity. Statistical analysis, employing an ANOVA test, revealed the high significance of the constructed models with the licorice concentration being the key independent factor affecting all dependent outputs. The pH as well as the viscosity of the prepared LHGs were positively influenced by licorice extract concentration, with higher concentrations leading to increased alkalinity and viscosity. Rheological behavior analysis revealed a pseudoplastic flow with demonstrated thixotropy which is advantageous for application and prolongation of residence time. The wound healing process was assessed through ulcer size, traumatic ulcer healing score (UHS), collagen-1 expression (COL-1), growth factors (EGF, VEGF), pro-inflammatory markers (TNF-α), wound healing score (WHS). LHGs prepared using higher levels of both factors, 30% dried licorice root extract and 4% HEC, demonstrated enhanced wound healing, elevated growth factor expression of 66.67% and 23.24%, respectively, and 88% reduced inflammation compared to the control group, indicating their potential in expediting oral ulcer recovery. Overall, these findings highlight the promising role of green licorice-based hydrogels in promoting sustainable oral mucosal healing.
References: Protein Cell. 2018 May;9(5):488-500. (PMID: 29736705)
J Ethnopharmacol. 2005 Jul 14;99(3):317-24. (PMID: 15978760)
J Oral Maxillofac Surg. 1993 Mar;51(3):243-8; discussion 248-9. (PMID: 8445464)
Microorganisms. 2023 May 11;11(5):. (PMID: 37317243)
Int J Pharm. 2023 Jul 25;642:123113. (PMID: 37301242)
Bioengineering (Basel). 2022 Dec 03;9(12):. (PMID: 36550967)
Int J Mol Sci. 2021 Sep 01;22(17):. (PMID: 34502429)
Int J Biol Macromol. 2023 Aug 30;247:125808. (PMID: 37460072)
Biomed Pharmacother. 2021 Nov;143:112151. (PMID: 34507115)
J Microbiol Biotechnol. 2021 Dec 28;31(12):1656-1666. (PMID: 34489380)
Int J Biol Macromol. 2023 Jun 30;241:124538. (PMID: 37085064)
J Taibah Univ Med Sci. 2021 Feb 04;16(3):431-439. (PMID: 34140871)
J Indian Soc Periodontol. 2022 Jan-Feb;26(1):51-57. (PMID: 35136317)
Burns. 2007 Jun;33(4):484-94. (PMID: 17223272)
AAPS PharmSciTech. 2018 Apr;19(3):1001-1010. (PMID: 29110291)
Front Physiol. 2016 Nov 02;7:507. (PMID: 27853435)
Nature. 2008 May 15;453(7193):314-21. (PMID: 18480812)
ILAR J. 1997;38(1):41-48. (PMID: 11528046)
Int J Biol Macromol. 2023 Apr 15;234:123718. (PMID: 36801307)
Am J Transl Res. 2023 Jul 15;15(7):4467-4486. (PMID: 37560210)
Drug Target Insights. 2023 Jun 05;17:70-77. (PMID: 37288311)
Biomimetics (Basel). 2022 Jul 01;7(3):. (PMID: 35892357)
Pharmaceutics. 2023 Feb 14;15(2):. (PMID: 36839959)
Biomed Res Int. 2013;2013:754802. (PMID: 23484152)
Biomed Rep. 2019 Aug;11(2):47-50. (PMID: 31384457)
Acta Cir Bras. 2011 Jun;26(3):227-34. (PMID: 21537526)
J Colloid Interface Sci. 2021 Sep 15;598:444-454. (PMID: 33930748)
J Antibiot (Tokyo). 2023 May;76(5):291-300. (PMID: 36854977)
J Ayurveda Integr Med. 2020 Jan - Mar;11(1):82-88. (PMID: 30391123)
Indian J Dent Res. 2013 Sep-Oct;24(5):593-8. (PMID: 24355961)
Sci Rep. 2022 Nov 2;12(1):18529. (PMID: 36323953)
Iran J Med Sci. 2023 Sep;48(5):437-447. (PMID: 37786470)
Matrix Biol. 2016 Jan;49:25-36. (PMID: 26278492)
فهرسة مساهمة: Keywords: green synthesis; hydrogels; hydroxyethyl cellulose; licorice; oral ulcer; sustainability
تواريخ الأحداث: Date Created: 20231223 Latest Revision: 20231225
رمز التحديث: 20231225
مُعرف محوري في PubMed: PMC10748055
DOI: 10.3390/pharmaceutics15122734
PMID: 38140075
قاعدة البيانات: MEDLINE
الوصف
تدمد:1999-4923
DOI:10.3390/pharmaceutics15122734