دورية أكاديمية
أعرض في EDS

Unveiling the Pain Relief Potential: Harnessing Analgesic Peptides from Animal Venoms.

التفاصيل البيبلوغرافية
العنوان: Unveiling the Pain Relief Potential: Harnessing Analgesic Peptides from Animal Venoms.
المؤلفون: Pereira AFM; Center for the Study of Venoms and Venomous Animals (CEVAP), São Paulo State University (UNESP-Univ Estadual Paulista), Botucatu 01419-901, SP, Brazil., Cavalcante JS; Graduate Program in Tropical Diseases, Botucatu Medical School (FMB), São Paulo State University (UNESP-Univ Estadual Paulista), Botucatu 01419-901, SP, Brazil., Angstmam DG; Graduate Program in Tropical Diseases, Botucatu Medical School (FMB), São Paulo State University (UNESP-Univ Estadual Paulista), Botucatu 01419-901, SP, Brazil., Almeida C; Center of Mathematics, Computing Sciences and Cognition, Federal University of ABC, Santo André 09280-560, SP, Brazil., Soares GS; Delphina Rinaldi Abdel Azil Hospital and Emergency Room (HPSDRAA), Manaus 69093-415, AM, Brazil., Pucca MB; Department of Clinical Analysis, School of Pharmaceutical Sciences, São Paulo State University, Araraquara 14801-320, SP, Brazil., Ferreira Junior RS; Center for the Study of Venoms and Venomous Animals (CEVAP), São Paulo State University (UNESP-Univ Estadual Paulista), Botucatu 01419-901, SP, Brazil.; Graduate Program in Tropical Diseases, Botucatu Medical School (FMB), São Paulo State University (UNESP-Univ Estadual Paulista), Botucatu 01419-901, SP, Brazil.; Center for Translational Science and Development of Biopharmaceuticals FAPESP/CEVAP, São Paulo State University (UNESP-Univ Estadual Paulista), Botucatu 01419-901, SP, Brazil.
المصدر: Pharmaceutics [Pharmaceutics] 2023 Dec 13; Vol. 15 (12). Date of Electronic Publication: 2023 Dec 13.
نوع المنشور: Journal Article; Review
اللغة: English
بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101534003 Publication Model: Electronic Cited Medium: Print ISSN: 1999-4923 (Print) Linking ISSN: 19994923 NLM ISO Abbreviation: Pharmaceutics Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: Basel, Switzerland : MDPI
مستخلص: The concept of pain encompasses a complex interplay of sensory and emotional experiences associated with actual or potential tissue damage. Accurately describing and localizing pain, whether acute or chronic, mild or severe, poses a challenge due to its diverse manifestations. Understanding the underlying origins and mechanisms of these pain variations is crucial for effective management and pharmacological interventions. Derived from a wide spectrum of species, including snakes, arthropods, mollusks, and vertebrates, animal venoms have emerged as abundant repositories of potential biomolecules exhibiting analgesic properties across a broad spectrum of pain models. This review focuses on highlighting the most promising venom-derived toxins investigated as potential prototypes for analgesic drugs. The discussion further encompasses research prospects, challenges in advancing analgesics, and the practical application of venom-derived toxins. As the field continues its evolution, tapping into the latent potential of these natural bioactive compounds holds the key to pioneering approaches in pain management and treatment. Therefore, animal toxins present countless possibilities for treating pain caused by different diseases. The development of new analgesic drugs from toxins is one of the directions that therapy must follow, and it seems to be moving forward by recommending the composition of multimodal therapy to combat pain.
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معلومات مُعتمدة: 2023/01554-1 São Paulo Research Foundation; 2021/11936-3 São Paulo Research Foundation; 301608/2022-9 National Council for Scientific and Technological Development
فهرسة مساهمة: Keywords: analgesic peptides; animal venoms; biomolecules; pain treatment; toxins
تواريخ الأحداث: Date Created: 20231223 Latest Revision: 20231225
رمز التحديث: 20231225
مُعرف محوري في PubMed: PMC10748172
DOI: 10.3390/pharmaceutics15122766
PMID: 38140106
قاعدة البيانات: MEDLINE
الوصف
تدمد:1999-4923
DOI:10.3390/pharmaceutics15122766