دورية أكاديمية
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Organic Electrochemical Transistor Aptasensor for Interleukin-6 Detection.

التفاصيل البيبلوغرافية
العنوان: Organic Electrochemical Transistor Aptasensor for Interleukin-6 Detection.
المؤلفون: Diacci C; Laboratory of Organic Electronics, Department of Science and Technology, Linköping University, 601 74, Norrköping, Sweden.; Dipartimento di Scienze della Vita, Università di Modena e Reggio Emilia, via Campi 103, 41125 Modena, Italy., Burtscher B; Laboratory of Organic Electronics, Department of Science and Technology, Linköping University, 601 74, Norrköping, Sweden., Berto M; Dipartimento di Scienze della Vita, Università di Modena e Reggio Emilia, via Campi 103, 41125 Modena, Italy., Ruoko TP; Laboratory of Organic Electronics, Department of Science and Technology, Linköping University, 601 74, Norrköping, Sweden., Lienemann S; Laboratory of Organic Electronics, Department of Science and Technology, Linköping University, 601 74, Norrköping, Sweden., Greco P; Department of Neuroscience and Rehabilitation, Università di Ferrara, Via Borsari 46, 44121 Ferrara, Italy.; Center for Translational Neurophysiology of Speech and Communication, Istituto Italiano di Tecnologia, via Fossato di Mortara 17-193, 44100 Ferrara, Italy., Berggren M; Laboratory of Organic Electronics, Department of Science and Technology, Linköping University, 601 74, Norrköping, Sweden., Borsari M; Dipartimento di Scienze Chimiche e Geologiche, Università di Modena e Reggio Emilia, via Campi 103, 41125 Modena, Italy., Simon DT; Laboratory of Organic Electronics, Department of Science and Technology, Linköping University, 601 74, Norrköping, Sweden., Bortolotti CA; Dipartimento di Scienze della Vita, Università di Modena e Reggio Emilia, via Campi 103, 41125 Modena, Italy., Biscarini F; Dipartimento di Scienze della Vita, Università di Modena e Reggio Emilia, via Campi 103, 41125 Modena, Italy.; Center for Translational Neurophysiology of Speech and Communication, Istituto Italiano di Tecnologia, via Fossato di Mortara 17-193, 44100 Ferrara, Italy.
المصدر: ACS applied materials & interfaces [ACS Appl Mater Interfaces] 2023 Dec 23. Date of Electronic Publication: 2023 Dec 23.
Publication Model: Ahead of Print
نوع المنشور: Journal Article; Review
اللغة: English
بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101504991 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1944-8252 (Electronic) Linking ISSN: 19448244 NLM ISO Abbreviation: ACS Appl Mater Interfaces Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Washington, D.C. : American Chemical Society
مستخلص: We demonstrate an organic electrochemical transistor (OECT) biosensor for the detection of interleukin 6 (IL6), an important biomarker associated with various pathological processes, including chronic inflammation, inflammaging, cancer, and severe COVID-19 infection. The biosensor is functionalized with oligonucleotide aptamers engineered to bind specifically IL6. We developed an easy functionalization strategy based on gold nanoparticles deposited onto a poly(3,4-ethylenedioxythiophene) doped with polystyrenesulfonate (PEDOT:PSS) gate electrode for the subsequent electrodeposition of thiolated aptamers. During this functionalization step, the reduction of sulfide bonds allows for simultaneous deposition of a blocking agent. A detection range from picomolar to nanomolar concentrations for IL6 was achieved, and the selectivity of the device was assessed against Tumor Necrosis Factor (TNF), another cytokine involved in the inflammatory processes.
فهرسة مساهمة: Keywords: Aptamer; Biosensor; Cytokine; Interleukin-6; Organic electrochemical transistor; aptasensor
تواريخ الأحداث: Date Created: 20231223 Latest Revision: 20231223
رمز التحديث: 20231223
DOI: 10.1021/acsami.3c12397
PMID: 38141020
قاعدة البيانات: MEDLINE
الوصف
تدمد:1944-8252
DOI:10.1021/acsami.3c12397