Correlation between Anatomopathological Aspects and Pelvic Pain in Women with Deep Infiltrating Endometriosis.

التفاصيل البيبلوغرافية
العنوان:	Correlation between Anatomopathological Aspects and Pelvic Pain in Women with Deep Infiltrating Endometriosis.
عنوان ترانسليتريتد:	Correlação entre aspectos anatomopatológicos e dor pélvica em mulheres com endometriose profunda.
المؤلفون:	Yela DA; School of Medicine, University of Campinas, Campinas - SP, Brazil., Silva MSS; School of Medicine, University of Campinas, Campinas - SP, Brazil., Eloy L; School of Medicine, University of Campinas, Campinas - SP, Brazil., Benetti-Pinto CL; School of Medicine, University of Campinas, Campinas - SP, Brazil.
المصدر:	Revista brasileira de ginecologia e obstetricia : revista da Federacao Brasileira das Sociedades de Ginecologia e Obstetricia [Rev Bras Ginecol Obstet] 2023 Dec; Vol. 45 (12), pp. e770-e774. Date of Electronic Publication: 2023 Dec 23.
نوع المنشور:	Journal Article
اللغة:	English
بيانات الدورية:	Publisher: Federação das Sociedades de Ginecologia e Obstetrícia Country of Publication: Brazil NLM ID: 9214757 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1806-9339 (Electronic) Linking ISSN: 01007203 NLM ISO Abbreviation: Rev Bras Ginecol Obstet Subsets: MEDLINE
أسماء مطبوعة:	Publication: 2024- : São Paulo : Federação das Sociedades de Ginecologia e Obstetrícia Original Publication: [São Paulo, Brazil] : Medisa Editora
مواضيع طبية MeSH:	Endometriosis/complications , Endometriosis/surgery , Endometriosis*/pathology, Humans ; Female ; Adult ; Middle Aged ; Retrospective Studies ; Pelvic Pain/etiology ; Pelvic Pain/diagnosis ; Tertiary Care Centers ; Endometrium/pathology
مستخلص:	Objective: To correlate the morphological aspects with pelvic pain in women with deep infiltrating endometriosis. Methods: A retrospective study with 67 women with deep endometriosis who underwent surgical treatment in a tertiary hospital from 2007 to 2017. The following variables were considered: age, parity, body mass index, site of involvement, hormonal treatment before surgery, pelvic pain, and morphometric analysis. The histological slides of the surgical specimens were revised and, using the ImageJ software for morphometric study, the percentages of stromal/glandular tissues were calculated in the histological sections. Results: The mean age of the women was 38.9 ± 6.5 years. The mean pain score was 8.8 ± 1.9 and the mean time of symptomatology was 4.7 ± 3.5 years, with 87% of the patients undergoing hormone treatment prior to surgery. The average expression of CD10, CK7, and S100 markers was 19.5 ± 11.8%, 9.4 ± 5.9%, and 7.9 ± 5.8% respectively. It was found that the greater the expression of CD10, the greater the level of pain ( p = 0.02). No correlation was observed between the expression of CD10, CK7, and S100 markers and age and duration of symptoms. Conclusion: Women with deep infiltrating endometriosis have a positive association between the level of pain and the fibrosis component in the endometrial tissue's histological composition. Competing Interests: The authors have no conflict of interests to declare. (Federação Brasileira de Ginecologia e Obstetrícia. This is an open access article published by Thieme under the terms of the Creative Commons Attribution License, permitting unrestricted use, distribution, and reproduction so long as the original work is properly cited. (https://creativecommons.org/licenses/by/4.0/).)
فهرسة مساهمة:	Local Abstract: [Publisher, Portuguese] Correlacionar os aspectos morfológicos com a dor pélvica em mulheres com endometriose profunda. MéTODOS: Estudo retrospectivo com 67 mulheres com endometriose profunda submetidas a tratamento cirúrgico em hospital terciário de 2007 a 2017. As seguintes variáveis foram consideradas: idade, paridade, índice de massa corporal, local do acometimento, tratamento hormonal antes da cirurgia, dor pélvica e análise morfométrica. As lâminas histológicas das peças cirúrgicas foram revisadas e, por meio do software ImageJ para estudo morfométrico, foram calculadas as porcentagens de tecidos estromais/glandulares nos cortes histológicos. [Publisher, Portuguese] A média etária das mulheres foi de 38,9 ± 6,5 anos. O escore de dor médio foi de 8,8 ± 1,9 e o tempo médio de sintomatologia foi de 4,7 ± 3,5 anos, sendo que 87% das pacientes realizavam tratamento hormonal antes da cirurgia. A expressão média dos marcadores CD10, CK7 e S100 foi de 19,5 ± 11,8%, 9,4 ± 5,9% e 7,9 ± 5,8%, respectivamente. Verificou-se que quanto maior a expressão de CD10, maior o nível de dor ( p = 0,02). Não foi observada correlação entre a expressão dos marcadores CD10, CK7 e S100 com a idade e duração dos sintomas. CONCLUSãO: Mulheres com endometriose profunda apresentam associação positiva entre o nível de dor e o componente de fibrose na composição histológica do tecido endometrial.
تواريخ الأحداث:	Date Created: 20231223 Date Completed: 20231225 Latest Revision: 20231225
رمز التحديث:	20231225
DOI:	10.1055/s-0043-1772473
PMID:	38141597
قاعدة البيانات:	MEDLINE

Full Text Finder

الوصف
تدمد:	1806-9339
DOI:	10.1055/s-0043-1772473