دورية أكاديمية
Development of cassava starch-based films incorporated with phenolic compounds produced by an Amazonian fungus.
| العنوان: | Development of cassava starch-based films incorporated with phenolic compounds produced by an Amazonian fungus. |
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| المؤلفون: | Falcão LS; School of Technology, Amazonas State University, UEA, Manaus, AM, Brazil; Institute of Environmental, Chemical and Pharmaceutical Sciences, Federal University of São Paulo, UNIFESP, Diadema, SP, Brazil., Oliveira IL; Institute of Environmental, Chemical and Pharmaceutical Sciences, Federal University of São Paulo, UNIFESP, Diadema, SP, Brazil., Gurgel RS; School of Technology, Amazonas State University, UEA, Manaus, AM, Brazil., de Souza ATF; School of Technology, Amazonas State University, UEA, Manaus, AM, Brazil., Mendonça LS; Faculty of Pharmaceutical Sciences, Federal University of Amazonas, UFAM, Manaus, AM, Brazil., Usuda ÉO; Institute of Environmental, Chemical and Pharmaceutical Sciences, Federal University of São Paulo, UNIFESP, Diadema, SP, Brazil., do Amaral TS; School of Technology, Amazonas State University, UEA, Manaus, AM, Brazil., Veggi PC; Institute of Environmental, Chemical and Pharmaceutical Sciences, Federal University of São Paulo, UNIFESP, Diadema, SP, Brazil., Campelo PH; Department of Food Technology, Federal University of Viçosa, Viçosa, MG, Brazil., de Vasconcellos MC; Faculty of Pharmaceutical Sciences, Federal University of Amazonas, UFAM, Manaus, AM, Brazil., Albuquerque PM; School of Technology, Amazonas State University, UEA, Manaus, AM, Brazil., de Moraes MA; Institute of Environmental, Chemical and Pharmaceutical Sciences, Federal University of São Paulo, UNIFESP, Diadema, SP, Brazil; School of Chemical Engineering, Universidade Estadual de Campinas, UNICAMP, Campinas, SP, Brazil. Electronic address: agostini@unicamp.br. |
| المصدر: | International journal of biological macromolecules [Int J Biol Macromol] 2024 Feb; Vol. 258 (Pt 1), pp. 128882. Date of Electronic Publication: 2023 Dec 21. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Country of Publication: Netherlands NLM ID: 7909578 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0003 (Electronic) Linking ISSN: 01418130 NLM ISO Abbreviation: Int J Biol Macromol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Amsterdam : Elsevier Original Publication: Guildford, Eng., IPC Science and Technology Press. |
| مواضيع طبية MeSH: | Antioxidants*/chemistry , Manihot*/chemistry, Phenols ; Starch/chemistry ; Fungi |
| مستخلص: | Drug-release systems have attracted attention over the last few years since they can be used as a substitute for traditional methods of drug delivery. These have the advantage of being directly administered at the treatment site and can maintain the drug at adequate levels for a longer period, thus increasing their efficacy. Starch-based films are interesting candidates for use as matrices for drug release, especially due to starch's non-toxic properties and its biocompatibility. Endophytic fungi are an important source of bioactive molecules, including secondary metabolites such as phenolic compounds with antioxidant activity. In the present study, cassava starch-based films were developed to act as release systems of phenolic compounds with antioxidant activity. The Amazonian endophytic fungus Aspergillus niger MgF2 was cultivated in liquid media, and the fungal extract was obtained by liquid-liquid partition with ethyl acetate. The starch-based films incorporated with the fungal extract were characterized in regards to their physicochemical properties. The release kinetics of the extract from the film and its antioxidant and cytotoxic properties were also evaluated. The films incorporated with the extract presented maximum release after 25 min at 37 °C and pH 6.8. In addition, it was observed that the antioxidant compounds of the fungal extract maintain their activity after being released from the film, and were non-toxic. Therefore, considering the promising physicochemical properties of the extract-incorporated films, and their considerable antioxidant capacity, the films demonstrate great biotechnological potential with diverse applications in the pharmacological and cosmetic industries. Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. (Copyright © 2023 Elsevier B.V. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Antioxidant activity; Aspergillus niger; Release systems |
| المشرفين على المادة: | 0 (Antioxidants) 0 (Phenols) 9005-25-8 (Starch) |
| تواريخ الأحداث: | Date Created: 20231223 Date Completed: 20240208 Latest Revision: 20240208 |
| رمز التحديث: | 20240208 |
| DOI: | 10.1016/j.ijbiomac.2023.128882 |
| PMID: | 38141712 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1879-0003 |
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| DOI: | 10.1016/j.ijbiomac.2023.128882 |