دورية أكاديمية
Single center experience using stereotactic body radiation therapy (SBRT) on orthotopic liver transplant protocol for unresectable cholangiocarcinoma.
| العنوان: | Single center experience using stereotactic body radiation therapy (SBRT) on orthotopic liver transplant protocol for unresectable cholangiocarcinoma. |
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| المؤلفون: | Wu TC; Department of Radiation Oncology, University of California, Los Angeles, 200 Medical Plaza Driveway, Suite B265, Los Angeles, CA, 90095, USA. Electronic address: tcwu@mednet.ucla.edu., Deng J; Department of Radiation Oncology, University of California, Los Angeles, 200 Medical Plaza Driveway, Suite B265, Los Angeles, CA, 90095, USA., Chu FI; Department of Radiation Oncology, University of California, Los Angeles, 200 Medical Plaza Driveway, Suite B265, Los Angeles, CA, 90095, USA., Sadeghi S; Department of Medical Oncology, University of California, Los Angeles, 200 Medical Plaza Driveway, Suite 120B, Los Angeles, CA, 90095, USA., Finn R; Department of Medical Oncology, University of California, Los Angeles, 200 Medical Plaza Driveway, Suite 120B, Los Angeles, CA, 90095, USA., Agopian VG; Department of Liver Transplant Surgery, University of California, Los Angeles, 924 Westwood Blvd, Los Angeles, CA, 90024, USA., Lee P; Department of Radiation Oncology, City of Hope Orange County, Lennar Foundation Cancer Center, 1000 Fivepoint, Irvine, CA, 92618, USA., Raldow AC; Department of Radiation Oncology, University of California, Los Angeles, 200 Medical Plaza Driveway, Suite B265, Los Angeles, CA, 90095, USA. |
| المصدر: | HPB : the official journal of the International Hepato Pancreato Biliary Association [HPB (Oxford)] 2024 Mar; Vol. 26 (3), pp. 444-450. Date of Electronic Publication: 2023 Dec 10. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Country of Publication: England NLM ID: 100900921 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1477-2574 (Electronic) Linking ISSN: 1365182X NLM ISO Abbreviation: HPB (Oxford) Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2016- : Oxford, UK : Elsevier Original Publication: 1999-2001: Oxford, England : ISIS Medical Media |
| مواضيع طبية MeSH: | Liver Transplantation*/adverse effects , Radiosurgery*/adverse effects , Radiosurgery*/methods , Cholangiocarcinoma*/radiotherapy , Cholangiocarcinoma*/surgery , Bile Duct Neoplasms*/radiotherapy , Bile Duct Neoplasms*/surgery, Humans ; Treatment Outcome ; Retrospective Studies ; Bile Ducts, Intrahepatic/pathology |
| مستخلص: | Purpose: To evaluate tolerability, pathologic response, and disease outcomes utilizing pre-operative stereotactic body radiation therapy (SBRT) followed by consolidation chemotherapy (CHT) prior to orthotopic liver transplant (OLT) in unresectable cholangiocarcinoma (CCA). Methods: This was a retrospective chart review of patients treated on OLT protocol at a single tertiary center from 2012 to 2019. Patients received pre-operative SBRT (40-50 Gy in 5 fractions) followed by CHT until progression or OLT. Progression-free survival (PFS) and overall survival (OS) were compared via log-rank test and Cox proportional hazards regression. Results: 26 patients (84.6% hilar, 15.4% intrahepatic) were identified for analysis. Eight patients (30.8%) patients developed acute toxicity after SBRT, mostly grade 1 nausea. Nine (34.6%) patients underwent OLT of which 4 (44.4%) achieved a pathologic complete response (pCR). Five (55.6%) OLT patients, including 2 pCR, developed recurrence at a median time of 49.9 weeks after OLT. 3-year OS for the OLT and dropout cohort was 75% and 9%, respectively (p < 0.0001). OS in hilar tumors only was statistically different for those that achieved a pCR (p = 0.014). Conclusions: Pre-operative SBRT is a well-tolerated and effective radiation technique as part of OLT protocol for unresectable CCA and conferred in a pCR rate of 44% within our cohort. (Published by Elsevier Ltd.) |
| تواريخ الأحداث: | Date Created: 20231223 Date Completed: 20240301 Latest Revision: 20240301 |
| رمز التحديث: | 20240301 |
| DOI: | 10.1016/j.hpb.2023.12.004 |
| PMID: | 38142182 |
| قاعدة البيانات: | MEDLINE |
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Full Text Finder | تدمد: | 1477-2574 |
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| DOI: | 10.1016/j.hpb.2023.12.004 |