دورية أكاديمية
Therapeutic Potential of Punica granatum and Isolated Compounds: Evidence-Based Advances to Treat Bacterial Infections.
| العنوان: | Therapeutic Potential of Punica granatum and Isolated Compounds: Evidence-Based Advances to Treat Bacterial Infections. |
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| المؤلفون: | Mendes PM; Department of Biology, Federal University of Maranhão, São Luís 65080-805, Brazil., Gomes Fontoura GM; Graduate Program in Health and Technology, Center of Sciences in Imperatriz, Federal University of Maranhão, Imperatriz 65915-240, Brazil., Rodrigues LDS; Department of Biology, Federal University of Maranhão, São Luís 65080-805, Brazil., Souza AS; Department of Medicine, Afya Faculty of Medical Sciences, Bragança 68600-000, Brazil., Viana JPM; Department of Cell Biology, University of Brasília, Brasília 70910-900, Brazil., Fernandes Pereira AL; Graduate Program in Health and Technology, Center of Sciences in Imperatriz, Federal University of Maranhão, Imperatriz 65915-240, Brazil., Dutra RP; Graduate Program in Health and Technology, Center of Sciences in Imperatriz, Federal University of Maranhão, Imperatriz 65915-240, Brazil., Nogueira Ferreira AG; Graduate Program in Health and Technology, Center of Sciences in Imperatriz, Federal University of Maranhão, Imperatriz 65915-240, Brazil., Neto MS; Graduate Program in Health and Technology, Center of Sciences in Imperatriz, Federal University of Maranhão, Imperatriz 65915-240, Brazil., Reis AS; Graduate Program in Health and Technology, Center of Sciences in Imperatriz, Federal University of Maranhão, Imperatriz 65915-240, Brazil., Berretta AA; Research, Development & Innovation Department, Apis Flora Industrial e Comercial Ltda, São Paulo 14020-670, Brazil., Monteiro-Neto V; Department of Pathology, Federal University of Maranhão, São Luís 65080-805, Brazil., Maciel MCG; Department of Cell Biology, University of Brasília, Brasília 70910-900, Brazil. |
| المصدر: | International journal of microbiology [Int J Microbiol] 2023 Dec 15; Vol. 2023, pp. 4026440. Date of Electronic Publication: 2023 Dec 15 (Print Publication: 2023). |
| نوع المنشور: | Journal Article; Review |
| اللغة: | English |
| بيانات الدورية: | Publisher: Hindawi Pub. Corp Country of Publication: Egypt NLM ID: 101516125 Publication Model: eCollection Cited Medium: Print ISSN: 1687-918X (Print) NLM ISO Abbreviation: Int J Microbiol Subsets: PubMed not MEDLINE |
| أسماء مطبوعة: | Original Publication: [Nasr City, Cairo] : Hindawi Pub. Corp. |
| مستخلص: | Punica granatum Linn has been known for its nutritional and medicinal value since ancient times and is used in the treatment of various pathologies owing to its antibacterial properties. This review reports the results of the most recent studies on the antibacterial effects of P. granatum and its isolated compounds on bacteria of clinical interest. A search in the PubMed, Scopus, Science Direct, and Science Citation Index Expanded (Web of Science) databases was performed, which included articles that evaluated the antibacterial activity of P. granatum extracts and excluded articles that analyzed other microorganisms or nonpathogenic bacteria, as well as theses, dissertations, duplicate articles, and those not fully available. The literature suggests that P. granatum extracts can act on bacteria, such as methicillin-sensitive Staphylococcus aureus (MSSA), methicillin-resistant S. aureus (MRSA), Streptococcus mutans , Escherichia coli , Pseudomonas aeruginosa , and Klebsiella pneumoniae . In addition, fruit peel was the most commonly used pharmacogen and methanol, ethanol, and water were the most common solvents for the extraction of bioactive compounds. The antibacterial potential of the methanolic extract of pomegranate peel could be attributed to the presence of active compounds, such as 5-hydroxymethylfurfural, punicic acid, gallic acid, and punicalagin. Thus, there is evidence that these plant extracts, having high polyphenol content, can disrupt the bacterial plasma membrane and inhibit the action of proteins related to antimicrobial resistance. P. granatum shows antibacterial activity against Gram-positive and Gram-negative bacteria, with great potential against multidrug-resistant strains. Further research is needed to clarify the mechanism of action related to this biological activity and investigate the isolated substances that may be responsible for the antibacterial effects. Competing Interests: The authors declare that they have no conflicts of interest regarding the publication of this paper. (Copyright © 2023 Priscila Mendonça Mendes et al.) |
| تواريخ الأحداث: | Date Created: 20231225 Latest Revision: 20231225 |
| رمز التحديث: | 20231225 |
| مُعرف محوري في PubMed: | PMC10746376 |
| DOI: | 10.1155/2023/4026440 |
| PMID: | 38144901 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1687-918X |
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| DOI: | 10.1155/2023/4026440 |