دورية أكاديمية
Concurrent glomerular PCDH7 deposits in PLA2R-associated membranous nephropathy.
| العنوان: | Concurrent glomerular PCDH7 deposits in PLA2R-associated membranous nephropathy. |
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| المؤلفون: | Fu N; Department of Nephrology, ShouGuang Chinese Medicine Hospital, No.3353 ShengCheng Street, ShouGuang, 262700, People's Republic of China., Yuan S; Graduate School of HeBei Medical University, No.361 East ZhongShan Boulevard, Shijiazhuang, 050011, People's Republic of China., Yang G; TaiYuan KingMed Center for Clinical Laboratory, No.2 LongSheng Street, Taiyuan, 030000, People's Republic of China., Li H; Department of Nephrology, Peking Union Medical College Hospital, No.1 ShuaiFuYuan, Beijing, 100010, People's Republic of China., Wang T; Department of Nephrology, The First Hospital of HeBei Medical University, No.89 DongGang Road, Shijiazhuang, 050030, People's Republic of China. nephrology2009@hotmail.com. |
| المصدر: | CEN case reports [CEN Case Rep] 2024 Aug; Vol. 13 (4), pp. 297-301. Date of Electronic Publication: 2023 Dec 25. |
| نوع المنشور: | Case Reports; Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Springer Japan Country of Publication: Japan NLM ID: 101636244 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2192-4449 (Electronic) Linking ISSN: 21924449 NLM ISO Abbreviation: CEN Case Rep Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Tokyo : Springer Japan, [2012]- |
| مواضيع طبية MeSH: | Glomerulonephritis, Membranous*/pathology , Glomerulonephritis, Membranous*/metabolism , Glomerulonephritis, Membranous*/diagnosis , Receptors, Phospholipase A2*/immunology , Protocadherins* , Cadherins*/metabolism , Kidney Glomerulus*/pathology , Kidney Glomerulus*/metabolism , Kidney Glomerulus*/ultrastructure, Humans ; Female ; Middle Aged ; Male |
| مستخلص: | The understanding of membranous nephropathy (MN) has undergone impressive advancements in the last 5 years, particularly due to identification of novel antigenic targets. M-type phospholipase A2 receptor (PLA2R) and thrombospondin type 1 domain-containing 7A (THSD7A) account for approximately 70% and 1-5% of the target antigens in primary MN, respectively. Recently, more novel/putative antigens have been identified in the remaining cases of MN that include exostosin 1/exostosin 2 (EXT1/EXT2), neural epidermal growth factor-like 1 protein (NELL-1), semaphorin 3B (SEMA3B) and protocadherin 7 (PCDH7). However, comparatively little is known about the PCDH7 among these novel antigens. As such, we herein described a unique case of positive glomerular PCDH7 deposits in PLA2R-associated MN, which may offer a deeper insight into the role of PCDH7 in MN and improve our understanding of glomerular diseases in the post-COVID era, particularly with the emerging variants. (© 2023. The Author(s), under exclusive licence to Japanese Society of Nephrology.) |
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| فهرسة مساهمة: | Keywords: Membranous nephropathy; Phospholipase A2 receptor; Podocytic antigen; Protocadherin 7; Renal pathology |
| المشرفين على المادة: | 0 (Receptors, Phospholipase A2) 0 (Protocadherins) 0 (Cadherins) 0 (PCDH7 protein, human) 0 (PLA2R1 protein, human) |
| تواريخ الأحداث: | Date Created: 20231225 Date Completed: 20240801 Latest Revision: 20240804 |
| رمز التحديث: | 20240804 |
| مُعرف محوري في PubMed: | PMC11294502 |
| DOI: | 10.1007/s13730-023-00842-2 |
| PMID: | 38145434 |
| قاعدة البيانات: | MEDLINE |
Find this article in full text from Springer Verlag. 
Full Text Finder | تدمد: | 2192-4449 |
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| DOI: | 10.1007/s13730-023-00842-2 |