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Novel Bidentate Amine Ligand and the Interplay between Pd(II) and Pt(II) Coordination and Biological Activity.

التفاصيل البيبلوغرافية
العنوان: Novel Bidentate Amine Ligand and the Interplay between Pd(II) and Pt(II) Coordination and Biological Activity.
المؤلفون: Oliveira LS; Institute of Chemistry, University of Campinas, Cidade Universitária Zeferino Vaz - Barão Geraldo, Campinas, São Paulo, Brazil., Rosa LB; Institute of Biology, University of Campinas, Cidade Universitária Zeferino Vaz -, Barão Geraldo, Campinas, São Paulo, Brazil., Affonso DD; Faculty of Pharmaceutical Sciences, University of Campinas, Cidade Universitária Zeferino Vaz -, Barão Geraldo, Campinas, São Paulo, Brazil., Santos IA; Institute of Biomedical Sciences, Federal University of Uberlândia, João Naves de Ávila Avenue, 2121 -, Santa Mônica, Uberlândia, Minas Gerais, Brazil.; School of Molecular and Cellular Biology, Faculty of Biological Sciences, University of Leeds, Woodhouse, Leeds, LS2 9JT, UK., Da Silva JC; Institute of Chemistry, University of Campinas, Cidade Universitária Zeferino Vaz - Barão Geraldo, Campinas, São Paulo, Brazil., Rodrigues GC; Institute of Chemistry, University of Campinas, Cidade Universitária Zeferino Vaz - Barão Geraldo, Campinas, São Paulo, Brazil., Harris M; School of Molecular and Cellular Biology, Faculty of Biological Sciences, University of Leeds, Woodhouse, Leeds, LS2 9JT, UK., Jardim ACG; Institute of Biomedical Sciences, Federal University of Uberlândia, João Naves de Ávila Avenue, 2121 -, Santa Mônica, Uberlândia, Minas Gerais, Brazil.; Institute of Biosciences, Humanities and Exact Sciences, São Paulo State University, Cristóvão Colombo street, 2265 -, Jardim Nazareth. São José do Rio Preto, São Paulo, Brazil., Nakahata DH; Institute of Chemistry, Federal University of Goiás, Esperança Avenue, Campus Samambaia., Goiânia, Goiás, Brazil., Sabino JR; Institute of Physics, Federal University of Goiás, Esperança Avenue, Campus Samambaia., Goiânia, Goiás, Brazil., de Carvalho JE; Faculty of Pharmaceutical Sciences, University of Campinas, Cidade Universitária Zeferino Vaz -, Barão Geraldo, Campinas, São Paulo, Brazil., Miguel DC; Institute of Biology, University of Campinas, Cidade Universitária Zeferino Vaz -, Barão Geraldo, Campinas, São Paulo, Brazil., Ruiz ALTG; Faculty of Pharmaceutical Sciences, University of Campinas, Cidade Universitária Zeferino Vaz -, Barão Geraldo, Campinas, São Paulo, Brazil., Abbehausen C; Institute of Chemistry, University of Campinas, Cidade Universitária Zeferino Vaz - Barão Geraldo, Campinas, São Paulo, Brazil.
المصدر: Chembiochem : a European journal of chemical biology [Chembiochem] 2024 Mar 15; Vol. 25 (6), pp. e202300696. Date of Electronic Publication: 2024 Feb 12.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Wiley-VCH Verlag Country of Publication: Germany NLM ID: 100937360 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1439-7633 (Electronic) Linking ISSN: 14394227 NLM ISO Abbreviation: Chembiochem Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Weinheim, Germany : Wiley-VCH Verlag, c2000-
مواضيع طبية MeSH: Antineoplastic Agents*/pharmacology , Antineoplastic Agents*/chemistry , Coordination Complexes*/pharmacology , Coordination Complexes*/chemistry, Platinum/pharmacology ; Platinum/chemistry ; Ligands ; Cisplatin ; Antiviral Agents/pharmacology ; Palladium/pharmacology ; Palladium/chemistry ; Crystallography, X-Ray ; Cell Line, Tumor
مستخلص: Pt(II) and Pd(II) coordinating N-donor ligands have been extensively studied as anticancer agents after the success of cisplatin. In this work, a novel bidentate N-donor ligand, the N-[[4-(phenylmethoxy)phenyl]methyl]-2-pyridinemethanamine, was designed to explore the antiparasitic, antiviral and antitumor activity of its Pt(II) and Pd(II) complexes. Chemical and spectroscopic characterization confirm the formation of [MLCl 2 ] complexes, where M=Pt(II) and Pd(II). Single crystal X-ray diffraction confirmed a square-planar geometry for the Pd(II) complex. Spectroscopic characterization of the Pt(II) complex suggests a similar structure. 1 H NMR, 195 Pt NMR and HR-ESI-MS(+) analysis of DMSO solution of complexes indicated that both compounds exchange the chloride trans to the pyridine for a solvent molecule with different reaction rates. The ligand and the two complexes were tested for in vitro antitumoral, antileishmanial, and antiviral activity. The Pt(II) complex resulted in a GI 50 of 10.5 μM against the NCI/ADR-RES (multidrug-resistant ovarian carcinoma) cell line. The ligand and the Pd(II) complex showed good anti-SARS-CoV-2 activity with around 65 % reduction in viral replication at a concentration of 50 μM.
(© 2023 Wiley-VCH GmbH.)
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معلومات مُعتمدة: MR/S001026/1 United Kingdom MRC_ Medical Research Council
فهرسة مساهمة: Keywords: Palladium; Platinum; SARS-CoV-2; antioxidant; cancer
المشرفين على المادة: 49DFR088MY (Platinum)
0 (Ligands)
Q20Q21Q62J (Cisplatin)
0 (Antineoplastic Agents)
0 (Antiviral Agents)
5TWQ1V240M (Palladium)
0 (Coordination Complexes)
تواريخ الأحداث: Date Created: 20231226 Date Completed: 20240318 Latest Revision: 20240326
رمز التحديث: 20240327
DOI: 10.1002/cbic.202300696
PMID: 38146865
قاعدة البيانات: MEDLINE
الوصف
تدمد:1439-7633
DOI:10.1002/cbic.202300696