دورية أكاديمية
Treatment of BK Polyomavirus-Associated Nephropathy in Paediatric Kidney Transplant Recipients: Leflunomide Versus Cidofovir.
| العنوان: | Treatment of BK Polyomavirus-Associated Nephropathy in Paediatric Kidney Transplant Recipients: Leflunomide Versus Cidofovir. |
|---|---|
| المؤلفون: | Kaya Aksoy G; From the Department of Pediatric Nephrology, Akdeniz University Faculty of Medicine, Antalya, Turkey., Erkan M, Koyun M, Çomak E, Toru HS, Mutlu D, Akkaya B, Akman S |
| المصدر: | Experimental and clinical transplantation : official journal of the Middle East Society for Organ Transplantation [Exp Clin Transplant] 2024 Jan; Vol. 22 (1), pp. 29-34. Date of Electronic Publication: 2023 Dec 26. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Bas̜kent University Country of Publication: Turkey NLM ID: 101207333 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2146-8427 (Electronic) Linking ISSN: 13040855 NLM ISO Abbreviation: Exp Clin Transplant Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: [Ankara] : Bas̜kent University, c2003- |
| مواضيع طبية MeSH: | Kidney Transplantation*/adverse effects , BK Virus* , Tumor Virus Infections*/diagnosis , Tumor Virus Infections*/drug therapy , Kidney Diseases*/diagnosis , Kidney Diseases*/drug therapy , Kidney Diseases*/surgery , Nephritis, Interstitial*/complications , Polyomavirus Infections*/diagnosis , Polyomavirus Infections*/drug therapy, Humans ; Male ; Child ; Female ; Leflunomide/adverse effects ; Cidofovir/adverse effects ; Viremia/diagnosis ; Retrospective Studies ; Creatinine ; Transplant Recipients |
| مستخلص: | Objectives: BK polyomavirus-associated nephropathy is a clinicopathological entity that negatively affects graft function in kidney transplant recipients. We compared the efficacy of leflunomide and cidofovir to treat BK polyomavirus-associated nephropathy in pediatric kidney transplant recipients. Materials and Methods: Medical records of pediatric recipients with BK viremia for the period 2004 through 2019 were reviewed retrospectively, and patients diagnosed with BK polyomavirusassociated nephro-pathy were included in the study. A serum BK virus level above 104 copies/mL was accepted as BK viremia. We defined BK polyomavirusassociated nephropathy as detection of BK virus SV40 antigen on immunochemistry staining of renal graft tissue accompanied by signs of tubulointerstitial nephritis or elevated serum creatinine in addition to BK viremia. Results: Of 304 kidney transplant recipients, 53 had persistent BK viremia; 36 of these patients (61.1% male) were included in the study with the diagnosis of BK polyomavirus-associated nephropathy. Twelve patients (33.3%) received cidofovir, and 14 (38.8%) received leflunomide. Results were similar between the cidofovir and leflunomide groups for serum creatinine level at last follow-up (0.91 ± 0.29 vs 0.94 ± 0.37 mg/dL, respectively; P = .843) and graft failure rate (8.3% vs 14.2%, respectively; P = .632). Graft failure was observed in 8.3% of patients with BK polyomavirus-associated nephropathy. Conclusions: Leflunomide and cidofovir showed similar efficacy for treatment of BK polyomavirus-associated nephropathy. |
| المشرفين على المادة: | G162GK9U4W (Leflunomide) JIL713Q00N (Cidofovir) AYI8EX34EU (Creatinine) |
| تواريخ الأحداث: | Date Created: 20231227 Date Completed: 20240131 Latest Revision: 20240131 |
| رمز التحديث: | 20240131 |
| DOI: | 10.6002/ect.2023.0091 |
| PMID: | 38149668 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 2146-8427 |
|---|---|
| DOI: | 10.6002/ect.2023.0091 |