دورية أكاديمية
Clinical and prognostic implications of heart failure hospitalization in patients with advanced heart failure.
| العنوان: | Clinical and prognostic implications of heart failure hospitalization in patients with advanced heart failure. |
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| المؤلفون: | Pagnesi M; Institute of Cardiology, ASST Spedali Civili, Department of Medical and Surgical specialties, Radiological sciences and Public Health, University of Brescia, Brescia., Sammartino AM; Institute of Cardiology, ASST Spedali Civili, Department of Medical and Surgical specialties, Radiological sciences and Public Health, University of Brescia, Brescia., Chiarito M; Humanitas Research Hospital IRCCS, Rozzano-Milan.; Department of Biomedical Sciences, Humanitas University, Pieve Emanuele-Milan., Stolfo D; Cardiovascular Department, Azienda Sanitaria Universitaria Giuliano Isontina (ASUGI), University of Trieste, Trieste., Baldetti L; Cardiac Intensive Care Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy., Adamo M; Institute of Cardiology, ASST Spedali Civili, Department of Medical and Surgical specialties, Radiological sciences and Public Health, University of Brescia, Brescia., Maggi G; Institute of Cardiology, ASST Spedali Civili, Department of Medical and Surgical specialties, Radiological sciences and Public Health, University of Brescia, Brescia., Inciardi RM; Institute of Cardiology, ASST Spedali Civili, Department of Medical and Surgical specialties, Radiological sciences and Public Health, University of Brescia, Brescia., Tomasoni D; Institute of Cardiology, ASST Spedali Civili, Department of Medical and Surgical specialties, Radiological sciences and Public Health, University of Brescia, Brescia., Loiacono F; Humanitas Research Hospital IRCCS, Rozzano-Milan., Maccallini M; Humanitas Research Hospital IRCCS, Rozzano-Milan.; Department of Biomedical Sciences, Humanitas University, Pieve Emanuele-Milan., Villaschi A; Humanitas Research Hospital IRCCS, Rozzano-Milan.; Department of Biomedical Sciences, Humanitas University, Pieve Emanuele-Milan., Gasparini G; Humanitas Research Hospital IRCCS, Rozzano-Milan.; Department of Biomedical Sciences, Humanitas University, Pieve Emanuele-Milan., Montella M; Humanitas Research Hospital IRCCS, Rozzano-Milan.; Department of Biomedical Sciences, Humanitas University, Pieve Emanuele-Milan., Contessi S; Cardiovascular Department, Azienda Sanitaria Universitaria Giuliano Isontina (ASUGI), University of Trieste, Trieste., Cocianni D; Cardiovascular Department, Azienda Sanitaria Universitaria Giuliano Isontina (ASUGI), University of Trieste, Trieste., Perotto M; Cardiovascular Department, Azienda Sanitaria Universitaria Giuliano Isontina (ASUGI), University of Trieste, Trieste., Barone G; Cardiac Intensive Care Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy., Merlo M; Cardiovascular Department, Azienda Sanitaria Universitaria Giuliano Isontina (ASUGI), University of Trieste, Trieste., Cappelletti AM; Cardiac Intensive Care Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy., Sinagra G; Cardiovascular Department, Azienda Sanitaria Universitaria Giuliano Isontina (ASUGI), University of Trieste, Trieste., Pini D; Humanitas Research Hospital IRCCS, Rozzano-Milan., Metra M; Institute of Cardiology, ASST Spedali Civili, Department of Medical and Surgical specialties, Radiological sciences and Public Health, University of Brescia, Brescia., Lombardi CM; Institute of Cardiology, ASST Spedali Civili, Department of Medical and Surgical specialties, Radiological sciences and Public Health, University of Brescia, Brescia. |
| المصدر: | Journal of cardiovascular medicine (Hagerstown, Md.) [J Cardiovasc Med (Hagerstown)] 2024 Feb 01; Vol. 25 (2), pp. 149-157. Date of Electronic Publication: 2023 Dec 22. |
| نوع المنشور: | Multicenter Study; Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Lippincott Williams & Wilkins Country of Publication: United States NLM ID: 101259752 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1558-2035 (Electronic) Linking ISSN: 15582027 NLM ISO Abbreviation: J Cardiovasc Med (Hagerstown) Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Hagerstown, MD : Lippincott Williams & Wilkins, c2006- |
| مواضيع طبية MeSH: | Ventricular Function, Left* , Heart Failure*/diagnosis , Heart Failure*/therapy , Heart Failure*/complications, Male ; Humans ; Middle Aged ; Aged ; Aged, 80 and over ; Female ; Prognosis ; Stroke Volume ; Hospitalization |
| مستخلص: | Background: Hospitalization is associated with poor outcomes in patients with heart failure, but its prognostic role in advanced heart failure is still unsettled. We evaluated the prognostic role of heart failure hospitalization in patients with advanced heart failure. Methods: The multicenter HELP-HF registry enrolled consecutive patients with heart failure and at least one high-risk 'I NEED HELP' marker. Characteristics and outcomes were compared between patients who were hospitalized for decompensated heart failure (inpatients) or not (outpatients) at the time of enrolment. The primary endpoint was the composite of all-cause mortality or first heart failure hospitalization. Results: Among the 1149 patients included [mean age 75.1 ± 11.5 years, 67.3% men, median left ventricular ejection fraction (LVEF) 35% (IQR 25-50%)], 777 (67.6%) were inpatients at the time of enrolment. As compared with outpatients, inpatients had lower LVEF, higher natriuretic peptides and a worse clinical profile. The 1-year rate of the primary endpoint was 50.9% in inpatients versus 36.8% in outpatients [crude hazard ratio 1.70, 95% confidence interval (CI) 1.39-2.07, P < 0.001]. At multivariable analysis, inpatient status was independently associated with a higher risk of the primary endpoint (adjusted hazard ratio 1.54, 95% CI 1.23-1.93, P < 0.001). Among inpatients, the independent predictors of the primary endpoint were older age, lower SBP, heart failure association criteria for advanced heart failure and glomerular filtration rate 30 ml/min/1.73 m2 or less. Conclusion: Hospitalization for heart failure in patients with at least one high-risk 'I NEED HELP' marker is associated with an extremely poor prognosis supporting the need for specific interventions, such as mechanical circulatory support or heart transplantation. (Copyright © 2023 Italian Federation of Cardiology - I.F.C. All rights reserved.) |
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| تواريخ الأحداث: | Date Created: 20231227 Date Completed: 20231228 Latest Revision: 20240409 |
| رمز التحديث: | 20240409 |
| DOI: | 10.2459/JCM.0000000000001581 |
| PMID: | 38149701 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1558-2035 |
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| DOI: | 10.2459/JCM.0000000000001581 |