دورية أكاديمية
أعرض في EDS

Dynamics of chikungunya virus transmission in the first year after its introduction in Brazil: A cohort study in an urban community.

التفاصيل البيبلوغرافية
العنوان: Dynamics of chikungunya virus transmission in the first year after its introduction in Brazil: A cohort study in an urban community.
المؤلفون: Anjos RO; Instituto Gonçalo Moniz, Fundação Oswaldo Cruz, Salvador, Brazil., Portilho MM; Instituto Gonçalo Moniz, Fundação Oswaldo Cruz, Salvador, Brazil., Jacob-Nascimento LC; Instituto Gonçalo Moniz, Fundação Oswaldo Cruz, Salvador, Brazil., Carvalho CX; Instituto Gonçalo Moniz, Fundação Oswaldo Cruz, Salvador, Brazil., Moreira PSS; Instituto Gonçalo Moniz, Fundação Oswaldo Cruz, Salvador, Brazil., Sacramento GA; Instituto Gonçalo Moniz, Fundação Oswaldo Cruz, Salvador, Brazil., Nery Junior NRR; Instituto Gonçalo Moniz, Fundação Oswaldo Cruz, Salvador, Brazil.; Instituto de Saúde Coletiva, Universidade Federal da Bahia, Salvador, Brazil., de Oliveira D; Instituto Gonçalo Moniz, Fundação Oswaldo Cruz, Salvador, Brazil., Cruz JS; Instituto Gonçalo Moniz, Fundação Oswaldo Cruz, Salvador, Brazil., Cardoso CW; Secretaria Municipal de Saúde de Salvador, Salvador, Brazil., Argibay HD; Instituto Gonçalo Moniz, Fundação Oswaldo Cruz, Salvador, Brazil.; Instituto de Saúde Coletiva, Universidade Federal da Bahia, Salvador, Brazil., Plante KS; World Reference Center for Emerging Viruses and Arboviruses, University of Texas Medical Branch, Galveston, Texas, United States of America., Plante JA; World Reference Center for Emerging Viruses and Arboviruses, University of Texas Medical Branch, Galveston, Texas, United States of America., Weaver SC; World Reference Center for Emerging Viruses and Arboviruses, University of Texas Medical Branch, Galveston, Texas, United States of America., Kitron UD; Emory University, Atlanta, Georgia, United States of America., Reis MG; Instituto Gonçalo Moniz, Fundação Oswaldo Cruz, Salvador, Brazil.; Faculdade de Medicina, Universidade Federal da Bahia, Salvador, Brazil.; Yale University, New Haven, Connecticut, United States of America., Ko AI; Instituto Gonçalo Moniz, Fundação Oswaldo Cruz, Salvador, Brazil.; Yale University, New Haven, Connecticut, United States of America., Costa F; Instituto Gonçalo Moniz, Fundação Oswaldo Cruz, Salvador, Brazil.; Instituto de Saúde Coletiva, Universidade Federal da Bahia, Salvador, Brazil.; Yale University, New Haven, Connecticut, United States of America.; University of Liverpool, Liverpool, United Kingdom.; Lancaster University, Lancaster, United Kingdom., Ribeiro GS; Instituto Gonçalo Moniz, Fundação Oswaldo Cruz, Salvador, Brazil.; Faculdade de Medicina, Universidade Federal da Bahia, Salvador, Brazil.
المصدر: PLoS neglected tropical diseases [PLoS Negl Trop Dis] 2023 Dec 27; Vol. 17 (12), pp. e0011863. Date of Electronic Publication: 2023 Dec 27 (Print Publication: 2023).
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101291488 Publication Model: eCollection Cited Medium: Internet ISSN: 1935-2735 (Electronic) Linking ISSN: 19352727 NLM ISO Abbreviation: PLoS Negl Trop Dis Subsets: MEDLINE
أسماء مطبوعة: Original Publication: San Francisco, CA : Public Library of Science
مواضيع طبية MeSH: Chikungunya virus* , Chikungunya Fever* , Zika Virus* , Zika Virus Infection*, Male ; Humans ; Female ; Cohort Studies ; Brazil/epidemiology ; Seroepidemiologic Studies ; Antibodies, Viral ; Immunoglobulin G
مستخلص: Background: The first chikungunya virus (CHIKV) outbreaks during the modern scientific era were identified in the Americas in 2013, reaching high attack rates in Caribbean countries. However, few cohort studies have been performed to characterize the initial dynamics of CHIKV transmission in the New World.
Methodology/principal Findings: To describe the dynamics of CHIKV transmission shortly after its introduction in Brazil, we performed semi-annual serosurveys in a long-term community-based cohort of 652 participants aged ≥5 years in Salvador, Brazil, between Feb-Apr/2014 and Nov/2016-Feb/2017. CHIKV infections were detected using an IgG ELISA. Cumulative seroprevalence and seroincidence were estimated and spatial aggregation of cases was investigated. The first CHIKV infections were identified between Feb-Apr/2015 and Aug-Nov/2015 (incidence: 10.7%) and continued to be detected at low incidence in subsequent surveys (1.7% from Aug-Nov/2015 to Mar-May/2016 and 1.2% from Mar-May/2016 to Nov/206-Feb/2017). The cumulative seroprevalence in the last survey reached 13.3%. It was higher among those aged 30-44 and 45-59 years (16.1% and 15.6%, respectively), compared to younger (12.4% and 11.7% in <15 and 15-29 years, respectively) or older (10.3% in ≥60 years) age groups, but the differences were not statistically significant. The cumulative seroprevalence was similar between men (14.7%) and women (12.5%). Yet, among those aged 15-29 years, men were more often infected than women (18.1% vs. 7.4%, respectively, P = 0.01), while for those aged 30-44, a non-significant opposite trend was observed (9.3% vs. 19.0%, respectively, P = 0.12). Three spatial clusters of cases were detected in the study site and an increased likelihood of CHIKV infection was detected among participants who resided with someone with CHIKV IgG antibodies.
Conclusions/significance: Unlike observations in other settings, the initial spread of CHIKV in this large urban center was limited and focal in certain areas, leaving a high proportion of the population susceptible to further outbreaks. Additional investigations are needed to elucidate the factors driving CHIKV spread dynamics, including understanding differences with respect to dengue and Zika viruses, in order to guide prevention and control strategies for coping with future outbreaks.
Competing Interests: I have read the journal’s policy and the authors of this manuscript have the following competing interests: A.I.K is an expert panel member for Reckitt Global Hygiene Institute and a scientific advisory committee member for Merck-related arboviral research but outside the scope of the manuscript. S.C.W. holds patents for alphavirus vaccine development. Other authors declare no conflict of interest
(Copyright: © 2023 Anjos et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.)
References: Insects. 2018 Dec 01;9(4):. (PMID: 30513725)
PLoS Negl Trop Dis. 2017 Jan 23;11(1):e0005334. (PMID: 28114414)
Clin Infect Dis. 2018 Nov 13;67(11):1760-1767. (PMID: 29697796)
Am J Trop Med Hyg. 2008 Feb;78(2):333-7. (PMID: 18256441)
BMJ Open. 2020 Oct 16;10(10):e040735. (PMID: 33067302)
Emerg Infect Dis. 2016 Jul;22(7):1221-8. (PMID: 27070192)
Indian J Med Res. 2018 Jan;147(1):88-96. (PMID: 29749366)
Arch Virol. 2021 Feb;166(2):347-361. (PMID: 33410995)
Emerg Infect Dis. 2015 May;21(5):906-7. (PMID: 25898939)
Am J Trop Med Hyg. 2016 Feb;94(2):393-396. (PMID: 26643536)
Int J Infect Dis. 2022 Sep;122:169-173. (PMID: 35568359)
Am J Trop Med Hyg. 2018 Nov;99(5):1321-1326. (PMID: 30226143)
PLoS Curr. 2016 Feb 01;8:. (PMID: 27330849)
J Virol. 2023 Jan 31;97(1):e0177822. (PMID: 36598200)
Stat Med. 2007 Apr 15;26(8):1824-33. (PMID: 17216592)
Euro Surveill. 2014 Jul 17;19(28):20854. (PMID: 25060573)
Nat Commun. 2017 May 19;8:15412. (PMID: 28524874)
PLoS Negl Trop Dis. 2017 Jan 12;11(1):e0005254. (PMID: 28081120)
PLoS Negl Trop Dis. 2022 Feb 4;16(2):e0010152. (PMID: 35120141)
Rev Panam Salud Publica. 2017 Aug 21;41:e59. (PMID: 28902272)
PLoS Negl Trop Dis. 2017 Jan 20;11(1):e0005319. (PMID: 28107342)
PLoS Med. 2022 Sep 8;19(9):e1004093. (PMID: 36074784)
Science. 2019 Feb 8;363(6427):607-610. (PMID: 30733412)
BMC Med. 2015 Apr 30;13:102. (PMID: 25976325)
mBio. 2017 Nov 14;8(6):. (PMID: 29138300)
Biomedica. 2017 Dec 01;37(4):507-515. (PMID: 29373771)
Clin Infect Dis. 2019 Sep 27;69(8):1353-1359. (PMID: 30561554)
New Microbes New Infect. 2015 Apr 15;7:23-5. (PMID: 26106482)
mBio. 2018 Mar 6;9(2):. (PMID: 29511072)
PLoS Negl Trop Dis. 2017 Jun 1;11(6):e0005654. (PMID: 28570693)
Emerg Infect Dis. 2018 Jun;24(6):995-1001. (PMID: 29774861)
Curr Opin Infect Dis. 2016 Oct;29(5):467-75. (PMID: 27472289)
J Immunol Res. 2015;2015:873404. (PMID: 26583158)
BMC Infect Dis. 2020 Nov 24;20(1):881. (PMID: 33234110)
Int J Infect Dis. 2021 Jul;108:443-453. (PMID: 33894353)
PLoS Negl Trop Dis. 2015 Jul 21;9(7):e0003937. (PMID: 26196686)
Salud Publica Mex. 2018 Jan-Feb;60(1):63-70. (PMID: 29689658)
PLoS Negl Trop Dis. 2016 Jun 20;10(6):e0004773. (PMID: 27322692)
PLoS Negl Trop Dis. 2015 May 07;9(5):e0003764. (PMID: 25951202)
Mem Inst Oswaldo Cruz. 2019 Feb 28;114:e180597. (PMID: 30843962)
Emerg Infect Dis. 2018 Apr;24(4):617-624. (PMID: 29553317)
Emerg Infect Dis. 2016 Feb;22(2):336-9. (PMID: 26812472)
Am J Trop Med Hyg. 2021 Oct 30;105(5):1281-1284. (PMID: 34460419)
PLoS Negl Trop Dis. 2014 May 29;8(5):e2927. (PMID: 24875389)
N Engl J Med. 2015 Mar 26;372(13):1231-9. (PMID: 25806915)
PLoS Negl Trop Dis. 2014 Feb 13;8(2):e2702. (PMID: 24551262)
Emerg Infect Dis. 2015 Dec;21(12):2274-6. (PMID: 26584464)
J Virol. 2012 Dec;86(23):13005-15. (PMID: 23015702)
J Infect Dis. 2021 Sep 1;224(5):860-864. (PMID: 33395487)
Rev Soc Bras Med Trop. 2020 Jun 22;53:e20190583. (PMID: 32578706)
Trans R Soc Trop Med Hyg. 2008 Aug;102(8):780-6. (PMID: 18400240)
Emerg Infect Dis. 2020 Jul;26(7):1364-1373. (PMID: 32568045)
PLoS Negl Trop Dis. 2016 Jan 15;10(1):e0004275. (PMID: 26771379)
J Infect Dis. 2021 Jul 2;224(1):101-108. (PMID: 33544850)
Epidemics. 2022 Mar;38:100541. (PMID: 35123281)
Rev Soc Bras Med Trop. 2019 Oct 03;52:e20190266. (PMID: 31596354)
معلومات مُعتمدة: U01 AI088752 United States AI NIAID NIH HHS; D43 TW010540 United States TW FIC NIH HHS; UL1 TR001863 United States TR NCATS NIH HHS; R25 TW009338 United States TW FIC NIH HHS; R24 AI120942 United States AI NIAID NIH HHS; R01 TW009504 United States TW FIC NIH HHS; R01 AI121207 United States AI NIAID NIH HHS; United Kingdom WT_ Wellcome Trust
المشرفين على المادة: 0 (Antibodies, Viral)
0 (Immunoglobulin G)
تواريخ الأحداث: Date Created: 20231227 Date Completed: 20240110 Latest Revision: 20240622
رمز التحديث: 20240622
مُعرف محوري في PubMed: PMC10775974
DOI: 10.1371/journal.pntd.0011863
PMID: 38150470
قاعدة البيانات: MEDLINE
الوصف
تدمد:1935-2735
DOI:10.1371/journal.pntd.0011863