دورية أكاديمية
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Neighborhood Perceptions Are Associated With Intrinsic Amygdala Activity and Resting-State Connectivity With Salience Network Nodes Among Older Adults.

التفاصيل البيبلوغرافية
العنوان: Neighborhood Perceptions Are Associated With Intrinsic Amygdala Activity and Resting-State Connectivity With Salience Network Nodes Among Older Adults.
المؤلفون: Ortiz-Whittingham LR; From the Social Determinants of Obesity and Cardiovascular Risk Laboratory (Ortiz-Whittingham, Ortiz-Chaparro, Baumer, Powell-Wiley), National Heart, Lung, and Blood Institute (NHLBI), National Institutes of Health, Bethesda, Maryland; Department of Electrical and Computer Engineering (Zhan), University of Pittsburgh, Pittsburgh, Pennslyvania; National Institute of Nursing Research (NINR), National Institutes of Health (Zenk), Bethesda, Maryland; Rush Alzheimer's Disease Center and the Department of Psychiatry and Behavioral Sciences (Lamar), Rush University Medical Center, Chicago, Illinois; and Intramural Research Program (Zenk, Powell-Wiley), National Institute on Minority Health and Health Disparities (NIMHD), National Institutes of Health, Bethesda, Maryland., Zhan L, Ortiz-Chaparro EN, Baumer Y, Zenk S, Lamar M, Powell-Wiley TM
المصدر: Psychosomatic medicine [Psychosom Med] 2024 Feb-Mar 01; Vol. 86 (2), pp. 116-123. Date of Electronic Publication: 2023 Dec 28.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Lippincott Williams & Wilkins Country of Publication: United States NLM ID: 0376505 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1534-7796 (Electronic) Linking ISSN: 00333174 NLM ISO Abbreviation: Psychosom Med Subsets: MEDLINE
أسماء مطبوعة: Publication: Hagerstown, MD : Lippincott Williams & Wilkins
Original Publication: Baltimore [etc.]
مواضيع طبية MeSH: Magnetic Resonance Imaging*/methods , Brain*, Humans ; Female ; Aged ; Male ; Gyrus Cinguli ; Amygdala/diagnostic imaging ; Brain Mapping
مستخلص: Objective: Neighborhood perceptions are associated with physical and mental health outcomes; however, the biological associates of this relationship remain to be fully understood. Here, we evaluate the relationship between neighborhood perceptions and amygdala activity and connectivity with salience network (i.e., insula, anterior cingulate, thalamus) nodes.
Methods: Forty-eight older adults (mean age = 68 [7] years, 52% female, 47% non-Hispanic Black, 2% Hispanic) without dementia or depression completed the Perceptions of Neighborhood Environment Scale. Lower scores indicated less favorable perceptions of aesthetic quality, walking environment, availability of healthy food, safety, violence (i.e., more perceived violence), social cohesion, and participation in activities with neighbors. Participants separately underwent resting-state functional magnetic resonance imaging.
Results: Less favorable perceived safety ( β = -0.33, pFDR = .04) and participation in activities with neighbors ( β = -0.35, pFDR = .02) were associated with higher left amygdala activity, independent of covariates including psychosocial factors. Less favorable safety perceptions were also associated with enhanced left amygdala functional connectivity with the bilateral insular cortices and the left anterior insula ( β = -0.34, pFDR = .04). Less favorable perceived social cohesion was associated with enhanced left amygdala functional connectivity with the right thalamus ( β = -0.42, pFDR = .04), and less favorable perceptions about healthy food availability were associated with enhanced left amygdala functional connectivity with the bilateral anterior insula (right: β = -0.39, pFDR = .04; left: β = -0.42, pFDR = .02) and anterior cingulate gyrus ( β = -0.37, pFDR = .04).
Conclusions: Taken together, our findings document relationships between select neighborhood perceptions and amygdala activity as well as connectivity with salience network nodes; if confirmed, targeted community-level interventions and existing community strengths may promote brain-behavior relationships.
(Copyright © 2023 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the American Psychosomatic Society.)
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معلومات مُعتمدة: ZIA HL006252 United States ImNIH Intramural NIH HHS; ZIA HL006168 United States ImNIH Intramural NIH HHS; R21 AG048176 United States AG NIA NIH HHS; ZIJ MD000010 United States ImNIH Intramural NIH HHS; ZIA HL006225 United States ImNIH Intramural NIH HHS; K01 AG040192 United States AG NIA NIH HHS
تواريخ الأحداث: Date Created: 20231227 Date Completed: 20240214 Latest Revision: 20240310
رمز التحديث: 20240310
مُعرف محوري في PubMed: PMC10922456
DOI: 10.1097/PSY.0000000000001272
PMID: 38150567
قاعدة البيانات: MEDLINE
الوصف
تدمد:1534-7796
DOI:10.1097/PSY.0000000000001272