دورية أكاديمية
أعرض في EDS

A genome-wide association study of 24-hour urinary excretion of endocrine disrupting chemicals.

التفاصيل البيبلوغرافية
العنوان: A genome-wide association study of 24-hour urinary excretion of endocrine disrupting chemicals.
المؤلفون: Lu X; Department of Epidemiology, University of Groningen, University Medical Center Groningen, 9713 GZ, Groningen, the Netherlands; Laboratory of Environmental Medicine and Developmental Toxicology, Shantou University Medical College, 515041, Guangdong, China., van der Meer TP; Department of Endocrinology, University of Groningen, University Medical Center Groningen, 9713 GZ, Groningen, the Netherlands., Kamali Z; Department of Epidemiology, University of Groningen, University Medical Center Groningen, 9713 GZ, Groningen, the Netherlands; Department of Bioinformatics, Isfahan University of Medical Sciences, Isfahan 81746-7346, Iran., van Faassen M; Department of Laboratory Medicine, University of Groningen, University Medical Center Groningen, 9713 GZ, Groningen, the Netherlands., Kema IP; Department of Laboratory Medicine, University of Groningen, University Medical Center Groningen, 9713 GZ, Groningen, the Netherlands., van Beek AP; Department of Endocrinology, University of Groningen, University Medical Center Groningen, 9713 GZ, Groningen, the Netherlands., Xu X; Laboratory of Environmental Medicine and Developmental Toxicology, Shantou University Medical College, 515041, Guangdong, China., Huo X; Laboratory of Environmental Medicine and Developmental Toxicology, Guangdong Key Laboratory of Environmental Pollution and Health, School of Environment, Jinan University, 510632, Guangdong, China., Ani A; Department of Epidemiology, University of Groningen, University Medical Center Groningen, 9713 GZ, Groningen, the Netherlands; Department of Bioinformatics, Isfahan University of Medical Sciences, Isfahan 81746-7346, Iran., Nolte IM; Department of Epidemiology, University of Groningen, University Medical Center Groningen, 9713 GZ, Groningen, the Netherlands., Wolffenbuttel BHR; Department of Endocrinology, University of Groningen, University Medical Center Groningen, 9713 GZ, Groningen, the Netherlands., van Vliet-Ostaptchouk JV; Department of Genetics, University of Groningen, University Medical Center Groningen, 9713 GZ, Groningen, the Netherlands., Snieder H; Department of Epidemiology, University of Groningen, University Medical Center Groningen, 9713 GZ, Groningen, the Netherlands. Electronic address: h.snieder@umcg.nl.
مؤلفون مشاركون: Lifelines Cohort Study
المصدر: Environment international [Environ Int] 2024 Jan; Vol. 183, pp. 108396. Date of Electronic Publication: 2023 Dec 20.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Elsevier Science Country of Publication: Netherlands NLM ID: 7807270 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-6750 (Electronic) Linking ISSN: 01604120 NLM ISO Abbreviation: Environ Int Subsets: MEDLINE
أسماء مطبوعة: Publication: : Amsterdam : Elsevier Science
Original Publication: Oxford; Elmsford, N. Y., Pergamon Press.
مواضيع طبية MeSH: Endocrine Disruptors*/urine , Phthalic Acids*/urine , Environmental Pollutants*/urine, Humans ; Environmental Exposure ; Genome-Wide Association Study ; Cytochrome P-450 CYP2C9
مستخلص: Ubiquitous exposure to environmental endocrine disrupting chemicals (EDCs) instigates a major public health problem, but much remains unknown on the inter-individual differences in metabolism and excretion of EDCs. To examine this we performed a two-stage genome-wide association study (GWAS) for 24-hour urinary excretions of four parabens, two bisphenols, and nine phthalate metabolites. Results showed five genome-wide significant (p-value < 5x10 -8 ) and replicated single nucleotide polymorphisms (SNPs) representing four independent signals that associated with mono-(2-ethyl-5-carboxypentyl) phthalate (MECPP) and mono-(2-ethyl-5-hydroxyhexyl) phthalate (MEHHP). Three of the four signals were located on chromosome 10 in a locus harboring the cytochrome P450 (CYP) genes CYP2C9, CYP2C58P, and CYP2C19 (rs117529685, p MECPP  = 5.38x10 -25 ; rs117033379, p MECPP  = 1.96x10 -19 ; rs4918798, p MECPP  = 4.01x10 -71 ; rs7895726, p MEHHP  = 1.37x10 -15 , r 2 with rs4918798 = 0.93). The other signal was on chromosome 6 close to the solute carrier (SLC) genes SLC17A1, SLC17A3, SLC17A4, and SCGN (rs1359232, p MECPP  = 7.6x10 -16 ). These four SNPs explained a substantial part (8.3 % - 9.2 %) of the variance in MECPP in the replication cohort. Bioinformatics analyses supported a likely causal role of CYP2C9 and SLC17A1 in metabolism and excretion of MECPP and MEHHP. Our results provide biological insights into mechanisms of phthalate metabolism and excretion with a likely causal role for CYP2C9 and SLC17A1.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2023 The Authors. Published by Elsevier Ltd.. All rights reserved.)
التعليقات: Erratum in: Environ Int. 2024 Apr 5;:108622. (PMID: 38582682)
فهرسة مساهمة: Keywords: Endocrine disruptor; Excretion; Genome-wide association study; Metabolism; Solute carrier; cytochrome P450
المشرفين على المادة: 6O7F7IX66E (phthalic acid)
0 (Endocrine Disruptors)
EC 1.14.13.- (Cytochrome P-450 CYP2C9)
0 (Phthalic Acids)
0 (Environmental Pollutants)
تواريخ الأحداث: Date Created: 20231227 Date Completed: 20240125 Latest Revision: 20240406
رمز التحديث: 20240407
DOI: 10.1016/j.envint.2023.108396
PMID: 38150807
قاعدة البيانات: MEDLINE
الوصف
تدمد:1873-6750
DOI:10.1016/j.envint.2023.108396