دورية أكاديمية
A Commentary on Fasting of Nonclinical Research Animals.
| العنوان: | A Commentary on Fasting of Nonclinical Research Animals. |
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| المؤلفون: | Gauvin DV; Department of Neurobehavioral Sciences, Charles River Laboratories - MWN, Mattawan, MI, USA., McComb M; Department of Neurobehavioral Sciences, Charles River Laboratories - MWN, Mattawan, MI, USA., Farero R; Department of Neurobehavioral Sciences, Charles River Laboratories - MWN, Mattawan, MI, USA. |
| المصدر: | International journal of toxicology [Int J Toxicol] 2024 Mar-Apr; Vol. 43 (2), pp. 196-208. Date of Electronic Publication: 2023 Dec 27. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Sage Publications Country of Publication: United States NLM ID: 9708436 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1092-874X (Electronic) Linking ISSN: 10915818 NLM ISO Abbreviation: Int J Toxicol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2009- : Thousand Oaks, CA : Sage Publications Original Publication: Washington, DC : Taylor & Francis, c1997- |
| مواضيع طبية MeSH: | Animal Care Committees* , Animal Experimentation*, Humans ; Animals ; Animals, Laboratory ; Animal Welfare ; Fasting |
| مستخلص: | This commentary discusses the implementation of fasting in nonclinical animal experimental subjects. The short-term removal of food from cages of experimental animals is in all respects innocuous. The term "stress" is ill-defined and the statutes and regulations governing animal research laboratories that exert their authority in the performance of their operations do so without substantive grounds to base compliance. The legislative and administrative history of the implementation of the Animal Welfare Act (AWA) has evolved into the development of laboratory management strategies that focus on the reduction of the biological cost of stress to the animals and the determination of when subclinical stress (eustress) becomes distress. Animal welfare is based on the tenet that in laboratories conducting animal research in compliance with Good Laboratory Practices (Title 21 USC, Chapter 13,§58), it is the study protocol and the study director that establish procedures and processes that are approved by each Institutional Animal Care and Use Committee to ensure the humane care and use of animals in research, teaching, and testing and to ensure compliance with guidelines and regulations. This approval process establishes the justification of eustress in the environment that do not rise to the threshold of distress under the AWA. Competing Interests: Declaration of Conflicting InterestsThe author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article. |
| فهرسة مساهمة: | Keywords: Institutional Animal Care and Use Committee; animal welfare; eustress; fasting; stress |
| تواريخ الأحداث: | Date Created: 20231227 Date Completed: 20240306 Latest Revision: 20240306 |
| رمز التحديث: | 20240306 |
| DOI: | 10.1177/10915818231218975 |
| PMID: | 38151260 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1092-874X |
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| DOI: | 10.1177/10915818231218975 |