التفاصيل البيبلوغرافية
| العنوان: |
Noninvasive Detection of Skin Cancer by Imprint Desorption Electrospray Ionization Mass Spectrometry Imaging. |
| المؤلفون: |
Meng Y; Department of Chemistry, Stanford University, Stanford, California 94305, United States., Chiou AS; Department of Dermatology, Stanford University School of Medicine, Stanford, California 94305, United States., Aasi SZ; Department of Dermatology, Stanford University School of Medicine, Stanford, California 94305, United States., See NA; Department of Dermatology, Stanford University School of Medicine, Stanford, California 94305, United States., Song X; Department of Chemistry, Stanford University, Stanford, California 94305, United States., Zare RN; Department of Chemistry, Stanford University, Stanford, California 94305, United States. |
| المصدر: |
Analytical chemistry [Anal Chem] 2024 Jan 09; Vol. 96 (1), pp. 28-32. Date of Electronic Publication: 2023 Dec 28. |
| نوع المنشور: |
Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: |
English |
| بيانات الدورية: |
Publisher: American Chemical Society Country of Publication: United States NLM ID: 0370536 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-6882 (Electronic) Linking ISSN: 00032700 NLM ISO Abbreviation: Anal Chem Subsets: MEDLINE |
| أسماء مطبوعة: |
Original Publication: Washington, American Chemical Society. |
| مواضيع طبية MeSH: |
Skin Neoplasms*/diagnostic imaging , Carcinoma, Basal Cell*/diagnosis, Humans ; Spectrometry, Mass, Electrospray Ionization/methods ; Fatty Acids |
| مستخلص: |
We report a technique for the noninvasive detection of skin cancer by imprint desorption electrospray ionization mass spectrometry imaging (DESI-MSI) using a transfer agent that is pressed against the tissue of interest. By noninvasively pressing a tape strip against human skin, metabolites, fatty acids, and lipids on the skin surface are transferred to the tape with little spatial distortion. Running DESI-MSI on the tape strip provides chemical images of the molecules on the skin surface, which are valuable for distinguishing cancer from healthy skin. Chemical components of the tissue imprint on the tape strip and the original basal cell carcinoma (BCC) section from the mass spectra show high consistency. By comparing MS images (about 150-μm resolution) of same molecules from the tape strip and from the BCC section, we confirm that chemical patterns are successfully transferred to the tape stripe. We also used the technique to distinguish cherry angiomas from normal human skin by comparing the molecular patterns from a tape strip. These results demonstrate the potential of the imprint DESI-MSI technique for the noninvasive detection of skin cancers as well as other skin diseases before and during clinical surgery. |
| المشرفين على المادة: |
0 (Fatty Acids) |
| تواريخ الأحداث: |
Date Created: 20231229 Date Completed: 20240110 Latest Revision: 20240213 |
| رمز التحديث: |
20240214 |
| DOI: |
10.1021/acs.analchem.3c04918 |
| PMID: |
38155587 |
| قاعدة البيانات: |
MEDLINE |
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