تقرير
A case of simultaneous breast cancer and ovarian cancer based on a hereditary breast and ovarian cancer syndrome.
| العنوان: | A case of simultaneous breast cancer and ovarian cancer based on a hereditary breast and ovarian cancer syndrome. |
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| المؤلفون: | Kotaka S; Department of Gynecologic Oncology, Aichi Cancer Center Hospital, Nagoya, Japan., Yasui H; Department of Gynecologic Oncology, Aichi Cancer Center Hospital, Nagoya, Japan., Tsubouchi H; Department of Gynecologic Oncology, Aichi Cancer Center Hospital, Nagoya, Japan., Mori M; Department of Gynecologic Oncology, Aichi Cancer Center Hospital, Nagoya, Japan., Kotani H; Department of Breast Oncology, Aichi Cancer Center Hospital, Nagoya, Japan., Yoshimura A; Department of Breast Oncology, Aichi Cancer Center Hospital, Nagoya, Japan., Ouchi A; Department of Gastroenterological Surgery, Aichi Cancer Center Hospital, Nagoya, Japan., Okuno M; Department of Gastroenterological Surgery, Aichi Cancer Center Hospital, Nagoya, Japan., Komori K; Department of Gastroenterological Surgery, Aichi Cancer Center Hospital, Nagoya, Japan., Shimizu Y; Department of Gastroenterological Surgery, Aichi Cancer Center Hospital, Nagoya, Japan., Suzuki S; Department of Gynecologic Oncology, Aichi Cancer Center Hospital, Nagoya, Japan. |
| المصدر: | Nagoya journal of medical science [Nagoya J Med Sci] 2023 Nov; Vol. 85 (4), pp. 814-821. |
| نوع المنشور: | Case Reports |
| اللغة: | English |
| بيانات الدورية: | Publisher: Nagoya University School Of Medicine Country of Publication: Japan NLM ID: 0412011 Publication Model: Print Cited Medium: Internet ISSN: 2186-3326 (Electronic) Linking ISSN: 00277622 NLM ISO Abbreviation: Nagoya J Med Sci Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Nagoya : Nagoya University School Of Medicine |
| مواضيع طبية MeSH: | Hereditary Breast and Ovarian Cancer Syndrome*/diagnosis , Hereditary Breast and Ovarian Cancer Syndrome*/genetics , Hereditary Breast and Ovarian Cancer Syndrome*/surgery , Breast Neoplasms*/genetics , Breast Neoplasms*/surgery , Breast Neoplasms*/pathology , Ovarian Neoplasms*/genetics , Ovarian Neoplasms*/surgery , Ovarian Neoplasms*/pathology , Carcinoma*/surgery, Humans ; Female ; Mastectomy |
| مستخلص: | We experienced a relatively rare case of synchronous breast and ovarian cancer in a patient with hereditary breast and ovarian cancer syndrome (HBOC). Here, we report the usefulness of laparoscopic examination to determine the subsequent treatment strategy in cases of suspected concurrent multiple carcinomas. Our patient was diagnosed with breast cancer following detection of a right breast mass. She was diagnosed with HBOC as she was found to be harboring a germline pathogenic variant of breast cancer susceptibility gene 1 ( BRCA1 ). Preoperative images suggested the presence of neoplastic masses in the abdominal cavity, and the possibility of metastatic peritoneal dissemination of breast cancer or concurrent overlapping of gynecological malignancies was considered. We decided to employ laparoscopic examination, and if simultaneous overlapping of cancers was suspected, we planned to further evaluate whether primary debulking surgery (PDS) for gynecological cancer was possible or not. Laparoscopy revealed the presence of ovarian cancer with neoplastic lesions on the bilateral ovaries and disseminations in the pelvic and abdominal cavities. The total predictive index was 0; therefore, PDS was considered feasible. We performed a total mastectomy, followed by laparotomy, and optimal surgery was achieved. The final diagnosis was simultaneous stage IIB invasive ductal breast carcinoma and stage IIIC high-grade serous ovarian carcinoma. In this case of suspected concurrent multiple carcinomas, laparoscopy was beneficial for decision-making regarding subsequent surgical treatment. We believe that the use of laparoscopy will enable simultaneous surgery for breast cancer and ovarian cancer to become one of the treatment strategies in the future. Competing Interests: None declared. |
| References: | Arch Clin Cases. 2021 Oct 27;6(3):69-75. (PMID: 34754911) Case Rep Oncol Med. 2019 Jan 6;2019:6958952. (PMID: 30723561) Front Oncol. 2020 Dec 14;10:608783. (PMID: 33381461) Biomed Res Int. 2022 Jun 6;2022:4557346. (PMID: 35707375) World J Surg Oncol. 2020 Jun 15;18(1):129. (PMID: 32539858) Am J Obstet Gynecol. 2013 Nov;209(5):462.e1-462.e11. (PMID: 23891632) N Engl J Med. 2018 Dec 27;379(26):2495-2505. (PMID: 30345884) J Clin Oncol. 2017 Feb 20;35(6):613-621. (PMID: 28029317) Lancet Oncol. 2008 Mar;9(3):297-303. (PMID: 18308255) Lancet. 2015 Jul 18;386(9990):249-57. (PMID: 26002111) BJOG. 2012 Jun;119(7):788-94. (PMID: 22530957) JAMA. 2017 Jun 20;317(23):2402-2416. (PMID: 28632866) JAMA Oncol. 2020 Sep 1;6(9):1390-1396. (PMID: 32789480) Ecancermedicalscience. 2008;2:109. (PMID: 22275985) N Engl J Med. 2019 Dec 19;381(25):2416-2428. (PMID: 31851799) Obstet Gynecol. 1994 Sep;84(3):449-52. (PMID: 8058246) Ann Surg Oncol. 2006 Aug;13(8):1156-61. (PMID: 16791447) Oncotarget. 2018 Jul 17;9(55):30649-30660. (PMID: 30093976) J Clin Oncol. 2008 Feb 10;26(5):778-85. (PMID: 18258986) N Engl J Med. 2021 Jun 24;384(25):2394-2405. (PMID: 34081848) |
| فهرسة مساهمة: | Keywords: breast cancer susceptibility gene 1; hereditary breast and ovarian cancer syndrome; laparoscopic examination; predictive index |
| تواريخ الأحداث: | Date Created: 20231229 Date Completed: 20240101 Latest Revision: 20240101 |
| رمز التحديث: | 20240101 |
| مُعرف محوري في PubMed: | PMC10751498 |
| DOI: | 10.18999/nagjms.85.4.814 |
| PMID: | 38155625 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 2186-3326 |
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| DOI: | 10.18999/nagjms.85.4.814 |