دورية أكاديمية
Mechanisms of Immune Sensing of DNA Damage.
| العنوان: | Mechanisms of Immune Sensing of DNA Damage. |
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| المؤلفون: | Goddard AM; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA; Department of Pathology and Laboratory Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA. Electronic address: annago4@email.unc.edu., Cho MG; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA., Lerner LM; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA; Genetics and Molecular Biology Curriculum, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA., Gupta GP; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA; Department of Radiation Oncology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA; Department of Biochemistry and Biophysics, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA. |
| المصدر: | Journal of molecular biology [J Mol Biol] 2024 Feb 15; Vol. 436 (4), pp. 168424. Date of Electronic Publication: 2023 Dec 29. |
| نوع المنشور: | Journal Article; Review; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Country of Publication: Netherlands NLM ID: 2985088R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1089-8638 (Electronic) Linking ISSN: 00222836 NLM ISO Abbreviation: J Mol Biol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Amsterdam : Elsevier Original Publication: 1959- : London : Academic Press |
| مواضيع طبية MeSH: | DNA Damage*/immunology , Neoplasms*/genetics , Neoplasms*/immunology , Neoplasms*/pathology , Innate Immunity Recognition*, Humans ; DNA Repair |
| مستخلص: | Genomic stability relies on a multifaceted and evolutionarily conserved DNA damage response (DDR). In multicellular organisms, an integral facet of the DDR involves the activation of the immune system to eliminate cells with persistent DNA damage. Recent research has shed light on a complex array of nucleic acid sensors crucial for innate immune activation in response to oncogenic stress-associated DNA damage, a process vital for suppressing tumor formation. Yet, these immune sensing pathways may also be co-opted to foster tolerance of chromosomal instability, thereby driving cancer progression. This review aims to provide an updated overview of how the innate immune system detects and responds to DNA damage. An improved understanding of the regulatory intricacies governing this immune response may uncover new avenues for cancer prevention and therapeutic intervention. Competing Interests: Declaration of competing interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: G.P.G. is a co-inventor on a patent held by the University of North Carolina at Chapel Hill on methods for detecting tumor-derived viral DNA in blood (U.S. Patent 11,168,373), receives patent licensing fees from and has equity in Naveris, Inc, and is the recipient of research funding from Breakpoint Therapeutics and Merck.A.M.G, M.G.C, and L.M.L. have no competing interests. (Copyright © 2023 Elsevier Ltd. All rights reserved.) |
| فهرسة مساهمة: | Keywords: DNA Damage; RNA sensing; cytosolic DNA sensing; immune sensing; sensors of replication-associated DNA damage |
| تواريخ الأحداث: | Date Created: 20231230 Date Completed: 20240220 Latest Revision: 20240502 |
| رمز التحديث: | 20240502 |
| DOI: | 10.1016/j.jmb.2023.168424 |
| PMID: | 38159716 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1089-8638 |
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| DOI: | 10.1016/j.jmb.2023.168424 |