دورية أكاديمية
Consuming a Linoleate-Rich Diet Increases Concentrations of Tetralinoleoyl Cardiolipin in Mouse Liver and Alters Hepatic Mitochondrial Respiration.
العنوان: | Consuming a Linoleate-Rich Diet Increases Concentrations of Tetralinoleoyl Cardiolipin in Mouse Liver and Alters Hepatic Mitochondrial Respiration. |
---|---|
المؤلفون: | Mahler CA; Lilly Diabetes Research Center, Indiana Biosciences Research Institute, Indianapolis, IN, United States., Snoke DB; Department of Medicine, University of Vermont, Larner College of Medicine, Burlington, VT, United States; Interdisciplinary PhD Program in Nutrition, The Ohio State University, Columbus, OH, United States., Cole RM; Interdisciplinary PhD Program in Nutrition, The Ohio State University, Columbus, OH, United States; Department of Food Science and Technology, The Ohio State University, Columbus, OH, United States., Angelotti A; Interdisciplinary PhD Program in Nutrition, The Ohio State University, Columbus, OH, United States; Department of Food Science and Technology, The Ohio State University, Columbus, OH, United States., Sparagna GC; Department of Medicine, Division of Cardiology, University of Colorado Anschutz Medical Campus, Aurora, CO, United States., Baskin KK; Department of Physiology and Cell Biology, Dorothy M. Davis Heart and Lung Research Institute, Diabetes and Metabolism Research Center, College of Medicine, The Ohio State University, Columbus, OH, United States., Ni A; Biostatistics, College of Public Health, The Ohio State University, Columbus, OH, United States., Belury MA; Department of Food Science and Technology, The Ohio State University, Columbus, OH, United States. Electronic address: Belury.1@osu.edu. |
المصدر: | The Journal of nutrition [J Nutr] 2024 Mar; Vol. 154 (3), pp. 856-865. Date of Electronic Publication: 2023 Dec 30. |
نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
اللغة: | English |
بيانات الدورية: | Publisher: Elsevier Country of Publication: United States NLM ID: 0404243 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1541-6100 (Electronic) Linking ISSN: 00223166 NLM ISO Abbreviation: J Nutr Subsets: MEDLINE |
أسماء مطبوعة: | Publication: 2023- : [New York, NY] : Elsevier Original Publication: 1928-1933 : Springfield, Ill. : C. C. Thomas |
مواضيع طبية MeSH: | Linoleic Acid* , Cardiolipins*/metabolism, Male ; Mice ; Animals ; Mitochondria ; Dietary Fats/metabolism ; Fatty Acids/metabolism ; Liver/metabolism ; Diet ; Phospholipids/metabolism ; Linoleic Acids/metabolism ; Respiration |
مستخلص: | Background: Hepatic mitochondrial dysfunction is a major cause of fat accumulation in the liver. Individuals with fatty liver conditions have hepatic mitochondrial structural abnormalities and a switch in the side chain composition of the mitochondrial phospholipid, cardiolipin, from poly- to monounsaturated fatty acids. Linoleic acid (LA), an essential dietary fatty acid, is required to remodel nascent cardiolipin (CL) to its tetralinoleoyl cardiolipin (L Objectives: The main aim of this study was to test the ability of a diet fortified with LA-rich safflower oil (SO), compared with the one fortified with lard (LD), to increase concentrations of L Methods: Twenty-four (9-wk-old) C57 BL/J6 male mice were fed either the SO or LD diets for ∼100 d, whereas food intake and body weight, fasting glucose, and glucose tolerance tests were performed to determine any changes in glycemic control. Results: Livers from mice fed SO diet had higher relative concentrations of hepatic L Conclusions: Our findings reveal that maintaining or increasing hepatic L (Copyright © 2023. Published by Elsevier Inc.) |
فهرسة مساهمة: | Keywords: Linoleic acid; cardiolipin; diet; liver; mitochondria |
المشرفين على المادة: | 9KJL21T0QJ (Linoleic Acid) 0 (Cardiolipins) 0 (Dietary Fats) 0 (Fatty Acids) 0 (Phospholipids) 0 (Linoleic Acids) |
تواريخ الأحداث: | Date Created: 20231231 Date Completed: 20240311 Latest Revision: 20240722 |
رمز التحديث: | 20240722 |
DOI: | 10.1016/j.tjnut.2023.12.037 |
PMID: | 38160803 |
قاعدة البيانات: | MEDLINE |
تدمد: | 1541-6100 |
---|---|
DOI: | 10.1016/j.tjnut.2023.12.037 |