دورية أكاديمية
Cardioprotective Effects of Solidago microglossa DC. in Nicotine-Treated Hypertensive Rats.
| العنوان: | Cardioprotective Effects of Solidago microglossa DC. in Nicotine-Treated Hypertensive Rats. |
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| المؤلفون: | Lopes KS; Laboratory of Cardiovascular Pharmacology (LaFaC), Faculty of Health Sciences, Federal University of Grande Dourados (UFGD), Dourados, MS, Brazil., Marques AAM; Laboratory of Cardiovascular Pharmacology (LaFaC), Faculty of Health Sciences, Federal University of Grande Dourados (UFGD), Dourados, MS, Brazil., Moreno KGT; Laboratory of Cardiovascular Pharmacology (LaFaC), Faculty of Health Sciences, Federal University of Grande Dourados (UFGD), Dourados, MS, Brazil., Dos Santos AC; Laboratory of Cardiovascular Pharmacology (LaFaC), Faculty of Health Sciences, Federal University of Grande Dourados (UFGD), Dourados, MS, Brazil., Souza RIC; Laboratory of Cardiovascular Pharmacology (LaFaC), Faculty of Health Sciences, Federal University of Grande Dourados (UFGD), Dourados, MS, Brazil., Lourenço ELB; Laboratory of Natural Products, Paranaense University (UNIPAR), Umuarama, PR, Brazil., Oliveira RJ; Centro de Estudos em Células Tronco, Terapia Celular e Genética Toxicológica (CeTroGen), Faculdade de Medicina (FAMED), Universidade Federal de Mato Grosso do Sul (UFMS), Campo Grande, Mato Grosso do Sul, Brazil., Gomes RDS; Department of Pharmaceutical Sciences, North Dakota State University, Fargo, North Dakota 58102, USA., Lívero FADR; Laboratory of Cardiometabolic Pharmacology, Federal University of Paraná, Curitiba, Brazil.; Laboratory of Preclinical Research of Natural Products, Paranaense University, Umuarama, Brazil., Gasparotto Junior A; Laboratory of Cardiovascular Pharmacology (LaFaC), Faculty of Health Sciences, Federal University of Grande Dourados (UFGD), Dourados, MS, Brazil. |
| المصدر: | Evidence-based complementary and alternative medicine : eCAM [Evid Based Complement Alternat Med] 2023 Dec 22; Vol. 2023, pp. 6611569. Date of Electronic Publication: 2023 Dec 22 (Print Publication: 2023). |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Hindawi Pub Country of Publication: United States NLM ID: 101215021 Publication Model: eCollection Cited Medium: Print ISSN: 1741-427X (Print) Linking ISSN: 1741427X NLM ISO Abbreviation: Evid Based Complement Alternat Med Subsets: PubMed not MEDLINE |
| أسماء مطبوعة: | Publication: 2011- : New York, NY : Hindawi Pub. Original Publication: Oxford, UK : Oxford University Press, c2004- |
| مستخلص: | Solidago microglossa DC. (Asteraceae), "arnica brasileira," is a Brazilian species popularly used to treat hypertension or renal ailments. This study investigated the cardioprotective effects of standardized S. microglossa extract (EESM) in nicotine-treated spontaneously hypertensive rats (SHRs). Moreover, the molecular mechanisms involved in the cardiovascular effects were also investigated. The acute toxicity was evaluated in female Wistar rats. Afterwards, six-month-old male spontaneously hypertensive rats received the EESM (14, 28, and 56 mg/kg), hydrochlorothiazide (25 mg/kg), and vehicle (filtered water; 0.1 mL/100 g) once daily for 28 days. All treatments were associated with 1.8 mg/kg of nicotine. At the end of the experimental period, the renal function, electrocardiographic profile, blood pressure, ventricular function, biochemical parameter, and mesenteric vascular bed reactivity were evaluated. Relative organ weights and cardiac morphometry were also investigated. Nicotine treatment in 6-month-old SHRs induced a significant reduction in renal function, with reduced urinary volume and lower renal elimination of sodium and creatinine. In addition, serum markers of the redox state and blood pressure levels remained significantly elevated, contributing to changes in vascular reactivity and left ventricular hypertrophy associated with reduced ventricular function. After 28 days of treatment, we found that the highest dose of EESM could mitigate all renal and cardiovascular changes developed by the nicotine-treated hypertensive rats. This study presented EESM as a possible cardioprotective drug that prevents cardiovascular dysfunctions in nicotine-treated hypertensive rats. Our data suggest EESM as a potential adjuvant therapy when cardioprotective effects are required. Competing Interests: The authors declare that they have no conflicts of interest. (Copyright © 2023 Katiana Simões Lopes et al.) |
| References: | Biochem Biophys Res Commun. 1989 Nov 30;165(1):284-91. (PMID: 2590227) Free Radic Res. 2012 Feb;46(2):154-63. (PMID: 22145946) Hypertension. 2019 Dec;74(6):1232-1265. (PMID: 31679425) Hypertension. 1985 Mar-Apr;7(2):244-52. (PMID: 2984118) Proc Jpn Acad Ser B Phys Biol Sci. 2006 Mar;82(1):17-24. (PMID: 25792766) Adv Exp Med Biol. 2017;956:129-147. (PMID: 27757938) Planta Med. 2022 Oct;88(13):1152-1162. (PMID: 35299274) Molecules. 2019 Mar 21;24(6):. (PMID: 30901869) Evid Based Complement Alternat Med. 2012;2012:272749. (PMID: 22474496) Circ Res. 2021 Apr 2;128(7):993-1020. (PMID: 33793335) Atherosclerosis. 2009 Jan;202(1):58-67. (PMID: 18436224) Antioxidants (Basel). 2019 Jun 22;8(6):. (PMID: 31234522) Am J Clin Nutr. 2008 Oct;88(4):1018-25. (PMID: 18842789) Arterioscler Thromb Vasc Biol. 2014 Mar;34(3):509-15. (PMID: 24554606) J Physiol. 1965 Mar;177:21-30. (PMID: 14296957) Circ J. 2019 Sep 25;83(10):1980-1985. (PMID: 31462607) J Ethnopharmacol. 2022 Jul 15;293:115255. (PMID: 35398499) BMC Complement Altern Med. 2019 Mar 20;19(1):72. (PMID: 30894170) J Cardiovasc Pharmacol. 1995;26 Suppl 3:S236-8. (PMID: 8587374) J Hum Hypertens. 2017 Aug;31(8):501-510. (PMID: 28230062) An Acad Bras Cienc. 2020;92(2):e20191201. (PMID: 32813866) J Ethnopharmacol. 2020 Aug 10;258:112916. (PMID: 32360045) Clin Sci (Lond). 2021 Aug 13;135(15):1791-1804. (PMID: 34338771) Evid Based Complement Alternat Med. 2020 Sep 29;2020:1726365. (PMID: 33062001) Phytomedicine. 2016 Oct 15;23(11):1082-9. (PMID: 26656228) Biofactors. 2000;12(1-4):169-74. (PMID: 11216481) Cells. 2020 Apr 22;9(4):. (PMID: 32331221) Fitoterapia. 2006 Sep;77(6):453-5. (PMID: 16843619) Eur J Pharmacol. 2000 May 12;396(1):33-7. (PMID: 10822051) Toxicology. 1995 Apr 12;98(1-3):57-63. (PMID: 7740554) |
| تواريخ الأحداث: | Date Created: 20240101 Latest Revision: 20240103 |
| رمز التحديث: | 20240103 |
| مُعرف محوري في PubMed: | PMC10756737 |
| DOI: | 10.1155/2023/6611569 |
| PMID: | 38161789 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1741-427X |
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| DOI: | 10.1155/2023/6611569 |