دورية أكاديمية
أعرض في EDS

Protective role of Cecropin AD against LPS-induced intestinal mucosal injury in chickens.

التفاصيل البيبلوغرافية
العنوان: Protective role of Cecropin AD against LPS-induced intestinal mucosal injury in chickens.
المؤلفون: Zhi Y; College of Animal Science and Technology, Beijing University of Agriculture, Beijing, China., Li T; College of Animal Science and Technology, Beijing University of Agriculture, Beijing, China., Li Y; College of Animal Science and Technology, Beijing University of Agriculture, Beijing, China., Zhang T; College of Animal Science and Technology, Beijing University of Agriculture, Beijing, China., Du M; College of Animal Science and Technology, Beijing University of Agriculture, Beijing, China., Zhang Q; College of Animal Science and Technology, Beijing University of Agriculture, Beijing, China., Wang X; Department of Otolaryngology Head and Neck Surgery, Beijing TongRen Hospital, Capital Medical University, the Key Laboratory of Otolaryngology-Head and Neck Surgery (Ministry of Education of China), Beijing Key Laboratory of Nasal Diseases, Beijing Institute of Otolaryngology, Beijing, China., Hu G; College of Animal Science and Technology, Beijing University of Agriculture, Beijing, China.
المصدر: Frontiers in immunology [Front Immunol] 2023 Dec 14; Vol. 14, pp. 1290182. Date of Electronic Publication: 2023 Dec 14 (Print Publication: 2023).
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Frontiers Research Foundation] Country of Publication: Switzerland NLM ID: 101560960 Publication Model: eCollection Cited Medium: Internet ISSN: 1664-3224 (Electronic) Linking ISSN: 16643224 NLM ISO Abbreviation: Front Immunol Subsets: MEDLINE
أسماء مطبوعة: Original Publication: [Lausanne : Frontiers Research Foundation]
مواضيع طبية MeSH: NLR Family, Pyrin Domain-Containing 3 Protein*/metabolism , Cecropins*, Animals ; Inflammasomes/metabolism ; Lipopolysaccharides/toxicity ; Chickens/metabolism ; Antioxidants/pharmacology
مستخلص: Introduction: Cecropin AD (CAD), a renowned antimicrobial peptide, has shown promising potential in treating various bacterial infections. This study investigates the protective effects of CAD against lipopolysaccharide (LPS)-induced intestinal adversities in chickens.
Methods: Sixty SPF-grade chicks were divided into groups and exposed to different dosages of CAD, followed by LPS administration. The study assessed the impact of CAD on intestinal mucosal injury markers, oxidative stress, and inflammation.
Results: LPS significantly increased Diamine oxidase (DAO) and D-lactate (D-LA) levels, both indicators of intestinal mucosal injury. CAD treatment substantially attenuated these elevations, particularly at higher dosages. Additionally, CAD markedly reduced oxidative stress in intestinal tissues, as shown by normalized antioxidant levels and decreased reactive oxygen species. Histological analysis supported these findings, showing better-preserved villi structures in CAD-treated groups. Furthermore, CAD significantly reduced IL-6 and IL-8 expression post-LPS stimulation and effectively regulated the NLRP3 inflammasome pathway, decreasing associated factors like NLRP3, Caspase-1, IL-1b, and IL-18.
Discussion: The study demonstrates CAD's therapeutic potential in alleviating LPS-induced intestinal injuries. The protective effects are primarily attributed to its anti-inflammatory and antioxidative actions and modulation of the NLRP3 inflammasome pathway.
Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
(Copyright © 2023 Zhi, Li, Li, Zhang, Du, Zhang, Wang and Hu.)
References: Biol Trace Elem Res. 2023 Jul;201(7):3461-3473. (PMID: 36208383)
Trends Immunol. 2011 Jun;32(6):256-64. (PMID: 21565554)
Inflamm Bowel Dis. 2011 Jun;17(6):1359-72. (PMID: 20872834)
J Cell Mol Med. 2017 Dec;21(12):3178-3189. (PMID: 28905500)
Gene. 2020 Sep 10;755:144897. (PMID: 32561323)
J Clin Med. 2019 May 10;8(5):. (PMID: 31083321)
Nat Rev Cardiol. 2018 Apr;15(4):203-214. (PMID: 29143812)
Asian-Australas J Anim Sci. 2017 Apr;30(4):576-584. (PMID: 27383796)
Cell Death Dis. 2019 Jul 17;10(8):542. (PMID: 31316052)
Dev Biol. 2008 Aug 1;320(1):1-11. (PMID: 18555213)
J Pediatr Gastroenterol Nutr. 2004 May;38(5):463-73. (PMID: 15097431)
Sci Total Environ. 2022 Nov 25;849:157921. (PMID: 35952865)
Avian Dis. 2014 Jun;58(2):297-302. (PMID: 25055636)
Front Nutr. 2022 Nov 03;9:1035619. (PMID: 36407513)
Mikrobiol Z. 2016 Nov-Dec;78(6):37-49. (PMID: 30141882)
Antibiotics (Basel). 2021 Jan 01;10(1):. (PMID: 33401476)
Animals (Basel). 2022 Jul 04;12(13):. (PMID: 35804628)
Anal Biochem. 2017 May 1;524:13-30. (PMID: 27789233)
J Hepatol. 2023 May;78(5):989-997. (PMID: 36702175)
Front Microbiol. 2022 Feb 17;13:820236. (PMID: 35250935)
Nucleic Acids Res. 2017 Mar 17;45(5):2687-2703. (PMID: 28168301)
J Gerontol A Biol Sci Med Sci. 2019 Jul 12;74(8):1149-1157. (PMID: 30256910)
Food Funct. 2023 Feb 6;14(3):1617-1626. (PMID: 36688440)
Fish Shellfish Immunol. 2013 Nov;35(5):1585-90. (PMID: 24041843)
Trends Pharmacol Sci. 2011 Mar;32(3):125-30. (PMID: 21216018)
J Biol Chem. 2009 Aug 28;284(35):23532-9. (PMID: 19578117)
ScientificWorldJournal. 2011 Jul 28;11:1536-47. (PMID: 21805022)
Microbes Infect. 2002 Jul;4(9):915-26. (PMID: 12106784)
Biol Trace Elem Res. 2020 Oct;197(2):660-666. (PMID: 31925740)
Ageing Res Rev. 2020 May;59:101036. (PMID: 32105850)
Pharm Biol. 2023 Dec;61(1):815-824. (PMID: 37194678)
J Nutr. 2019 Apr 1;149(4):553-565. (PMID: 30949678)
Biophys J. 2022 Nov 15;121(22):4368-4381. (PMID: 36199252)
Animal. 2022 Apr;16(4):100493. (PMID: 35338902)
Surgery. 1987 Jun;101(6):746-52. (PMID: 3589967)
Int Immunopharmacol. 2022 Jul;108:108768. (PMID: 35430433)
ACS Appl Mater Interfaces. 2023 May 24;15(20):24084-24096. (PMID: 37184257)
Mol Med Rep. 2018 Dec;18(6):5427-5436. (PMID: 30365119)
BMC Pharmacol Toxicol. 2018 Jan 10;19(1):3. (PMID: 29321061)
Nat Immunol. 2017 Jul 19;18(8):861-869. (PMID: 28722711)
J Colloid Interface Sci. 2018 Mar 1;513:141-150. (PMID: 29145017)
Nat Rev Microbiol. 2021 Jan;19(1):55-71. (PMID: 32887946)
Nature. 2012 Sep 13;489(7415):231-41. (PMID: 22972296)
Inflammation. 2015 Feb;38(1):384-93. (PMID: 25342286)
Antioxid Redox Signal. 2014 Jul 1;21(1):86-102. (PMID: 24359220)
Nat Immunol. 2015 May;16(5):448-57. (PMID: 25898198)
Mol Immunol. 2018 Dec;104:11-19. (PMID: 30396035)
Am J Physiol. 1996 Oct;271(4 Pt 1):G701-6. (PMID: 8897891)
J Adv Vet Anim Res. 2021 Nov 04;8(4):642-649. (PMID: 35106305)
Antioxidants (Basel). 2022 Sep 30;11(10):. (PMID: 36290692)
Growth Horm IGF Res. 2010 Jun;20(3):220-5. (PMID: 20185347)
Nat Rev Drug Discov. 2020 May;19(5):311-332. (PMID: 32107480)
Am J Physiol Gastrointest Liver Physiol. 2015 Jan 15;308(2):G139-50. (PMID: 25414099)
Front Aging Neurosci. 2022 Jun 10;14:879021. (PMID: 35754962)
J Ethnopharmacol. 2023 May 10;307:116231. (PMID: 36754190)
Methods. 2001 Dec;25(4):402-8. (PMID: 11846609)
J Immunol. 2009 Jul 15;183(2):787-91. (PMID: 19570822)
Cell Immunol. 2006 Oct;243(2):75-82. (PMID: 17292338)
Brain Behav Immun. 2019 Jul;79:24-38. (PMID: 30797959)
Fish Shellfish Immunol. 2020 May;100:117-125. (PMID: 32109613)
Animal. 2016 Oct;10(10):1619-25. (PMID: 27079952)
Mucosal Immunol. 2014 Sep;7(5):1139-50. (PMID: 24472848)
Metallomics. 2021 Mar 8;13(3):. (PMID: 33693770)
Biomolecules. 2023 Feb 27;13(3):. (PMID: 36979380)
Poult Sci. 2021 Dec;100(12):101481. (PMID: 34717121)
Front Pharmacol. 2022 Jan 31;13:806148. (PMID: 35173617)
Anim Sci J. 2015 Feb;86(2):153-8. (PMID: 25185977)
Br J Nutr. 2012 Nov 28;108(10):1756-63. (PMID: 22251659)
Front Immunol. 2019 Feb 28;10:276. (PMID: 30873162)
J Immunother. 2007 Apr;30(3):312-22. (PMID: 17414322)
Poult Sci. 2022 Apr;101(4):101701. (PMID: 35150943)
فهرسة مساهمة: Keywords: Cecropin AD (CAD); NLRP3 inflammasome; inflammatory markers; intestinal mucosal injury; lipopolysaccharide (LPS); oxidative stress
المشرفين على المادة: 0 (NLR Family, Pyrin Domain-Containing 3 Protein)
0 (Inflammasomes)
0 (Lipopolysaccharides)
0 (Cecropins)
0 (Antioxidants)
تواريخ الأحداث: Date Created: 20240101 Date Completed: 20240103 Latest Revision: 20240328
رمز التحديث: 20240329
مُعرف محوري في PubMed: PMC10757607
DOI: 10.3389/fimmu.2023.1290182
PMID: 38162646
قاعدة البيانات: MEDLINE
الوصف
تدمد:1664-3224
DOI:10.3389/fimmu.2023.1290182