دورية أكاديمية
Production of new ent-hardwickiic acid derivatives by microbial transformation and their antifungal activity.
| العنوان: | Production of new ent-hardwickiic acid derivatives by microbial transformation and their antifungal activity. |
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| المؤلفون: | Teixeira MVS; Department of Pharmaceutical Sciences, School of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo, Av. do Café, s/n, Ribeirão Preto 14040-903, SP, Brazil., Fernandes LM; Department of Pharmaceutical Sciences, School of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo, Av. do Café, s/n, Ribeirão Preto 14040-903, SP, Brazil., de Paula VS; Department of Pharmaceutical Sciences, School of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo, Av. do Café, s/n, Ribeirão Preto 14040-903, SP, Brazil., Ferreira AG; Laboratory of Nuclear Magnetic Resonance, Chemistry Department, Federal University of São Carlos, São Carlos 13565-905, SP, Brazil., Pires LM; Nucleus of Research in Sciences and Technology, University of Franca, Franca 14404-600, SP, Brazil., Santos RA; Nucleus of Research in Sciences and Technology, University of Franca, Franca 14404-600, SP, Brazil., Furtado NAJC; Department of Pharmaceutical Sciences, School of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo, Av. do Café, s/n, Ribeirão Preto 14040-903, SP, Brazil. Electronic address: niege@fcfrp.usp.br. |
| المصدر: | Fitoterapia [Fitoterapia] 2024 Mar; Vol. 173, pp. 105810. Date of Electronic Publication: 2023 Dec 30. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Country of Publication: Netherlands NLM ID: 16930290R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-6971 (Electronic) Linking ISSN: 0367326X NLM ISO Abbreviation: Fitoterapia Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 1999- : [Amsterdam] : Elsevier Original Publication: Milano : Inverni & Della Beffa S.p.A. |
| مواضيع طبية MeSH: | Antifungal Agents* , Fluconazole*/pharmacology , Diterpenes*, Candida ; Molecular Structure ; Microbial Sensitivity Tests |
| مستخلص: | Ent-hardwickiic acid is the major compound of Copaifera pubiflora Benth oleoresin traditionally used in Brazilian folk medicine as an antimicrobial agent. Microbial transformation of ent-hardwickiic by Cunninghamella elegans ATCC 10028b resulted in two and five antifungal derivatives (four new ones) produced in the Czapek modified and Koch's K1 media, respectively. The derivatives were isolated and their structures were determined by spectral analysis, namely 1D/2D NMR and HR-ESIMS. All compounds were tested for cytotoxic and antifungal activities and they were not cytotoxic to the tested cell lines, but all derivatives showed fungicidal activity against Candida glabrata and Candida krusei, which have emerged as resistant to fluconazole. One of the yet unreported biotransformation products displayed the strongest activity with minimum fungicidal concentration values smaller than the other compounds, including fluconazole. Competing Interests: Declaration of competing interest There are no conflicts of interest to declare. (Copyright © 2023 Elsevier B.V. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Antifungal compounds; Biotransformation; Candida glabrata; Candida krusei; Cunninghamella elegans; Ent-hardwickiic acid |
| المشرفين على المادة: | 0 (Antifungal Agents) 8VZV102JFY (Fluconazole) 24470-47-1 (hardwickic acid) 0 (Diterpenes) |
| تواريخ الأحداث: | Date Created: 20240101 Date Completed: 20240214 Latest Revision: 20240214 |
| رمز التحديث: | 20240214 |
| DOI: | 10.1016/j.fitote.2023.105810 |
| PMID: | 38163448 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1873-6971 |
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| DOI: | 10.1016/j.fitote.2023.105810 |